ID   LUZP2_DANRE             Reviewed;         346 AA.
AC   A5D8S1; A8WFS7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Leucine zipper protein 2;
DE   Flags: Precursor;
GN   Name=luzp2; ORFNames=si:dkeyp-86e4.1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Brain, and Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=A5D8S1-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=A5D8S1-2; Sequence=VSP_032044;
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DR   EMBL; BC141788; AAI41789.1; -; mRNA.
DR   EMBL; BC154442; AAI54443.1; -; mRNA.
DR   RefSeq; NP_001092725.1; NM_001099255.1.
DR   RefSeq; NP_001108187.1; NM_001114715.1. [A5D8S1-1]
DR   AlphaFoldDB; A5D8S1; -.
DR   SMR; A5D8S1; -.
DR   STRING; 7955.ENSDARP00000113593; -.
DR   PaxDb; A5D8S1; -.
DR   Ensembl; ENSDART00000111301; ENSDARP00000103583; ENSDARG00000068247. [A5D8S1-2]
DR   Ensembl; ENSDART00000146120; ENSDARP00000113593; ENSDARG00000068247. [A5D8S1-1]
DR   GeneID; 100137118; -.
DR   KEGG; dre:100137118; -.
DR   CTD; 338645; -.
DR   ZFIN; ZDB-GENE-060503-278; luzp2.
DR   eggNOG; ENOG502QV95; Eukaryota.
DR   GeneTree; ENSGT00390000013180; -.
DR   HOGENOM; CLU_068900_0_0_1; -.
DR   InParanoid; A5D8S1; -.
DR   OMA; TTVCDSQ; -.
DR   OrthoDB; 976560at2759; -.
DR   PhylomeDB; A5D8S1; -.
DR   TreeFam; TF331644; -.
DR   PRO; PR:A5D8S1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 18.
DR   Bgee; ENSDARG00000068247; Expressed in brain and 13 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR026718; Luzp2.
DR   PANTHER; PTHR22414; PTHR22414; 1.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Coiled coil; Glycoprotein; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000255"
FT   CHAIN           18..346
FT                   /note="Leucine zipper protein 2"
FT                   /id="PRO_0000315277"
FT   REGION          162..190
FT                   /note="Leucine-zipper"
FT   REGION          271..346
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          41..209
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        290..328
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        329..346
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        19
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        131
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        241
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        296
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   VAR_SEQ         253..287
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|Ref.1"
FT                   /id="VSP_032044"
FT   CONFLICT        205
FT                   /note="K -> R (in Ref. 1; AAI41789)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   346 AA;  39131 MW;  AB5970F369A457CF CRC64;
     MKFIGAVYLL FLLPALSFNS SYEGLEKKLK EVFTERTGIL RHLSKTSKEL DSIKGNLQSL
     KNEDAVPKKD VQRILELSHK QRDEMKSLQA ALQKQLDDAA ERAEKQQATI KFLKMEMEKK
     TKIIKDLQQE NKSLKNKLLS GNKLCDIHAE ESKKIQAQLK ELRYGKKDLI FKGQQLMDLE
     NKLKVAKDEL EKAALDKESQ LKALKDTVHI CFSSVLHSQT ASLHRFPATP TNLLRYSALV
     NNSRVTFQQP HMKDIPKVPR ITTTSKLPVS SAVMRRESTG PKDCQMVKVG SDCSHNQTES
     SSVMKKTFGH SQSKTPEQNG QGQARTAEES VKTDGELKKT QSDKHN