LUZP2_HUMAN
ID LUZP2_HUMAN Reviewed; 346 AA.
AC Q86TE4; A2RUB8; E9PN53; Q6UXE7; Q6ZS65;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Leucine zipper protein 2;
DE Flags: Precursor;
GN Name=LUZP2; ORFNames=UNQ2566/PRO6246;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Spinal cord;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16554811; DOI=10.1038/nature04632;
RA Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT "Human chromosome 11 DNA sequence and analysis including novel gene
RT identification.";
RL Nature 440:497-500(2006).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q86TE4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86TE4-2; Sequence=VSP_030520, VSP_030523;
CC Name=3;
CC IsoId=Q86TE4-3; Sequence=VSP_030521, VSP_030522;
CC Name=4;
CC IsoId=Q86TE4-4; Sequence=VSP_044970;
CC -!- SEQUENCE CAUTION:
CC Sequence=CAD90000.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY358386; AAQ88752.1; -; mRNA.
DR EMBL; AK127695; BAC87089.1; -; mRNA.
DR EMBL; AL832641; CAD90000.1; ALT_INIT; mRNA.
DR EMBL; AC023869; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC040968; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC067902; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC087373; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC115990; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC135168; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC132829; AAI32830.1; -; mRNA.
DR EMBL; BC151234; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS31446.1; -. [Q86TE4-1]
DR CCDS; CCDS58128.1; -. [Q86TE4-4]
DR RefSeq; NP_001009909.2; NM_001009909.3. [Q86TE4-1]
DR RefSeq; NP_001238937.1; NM_001252008.1. [Q86TE4-4]
DR RefSeq; NP_001238939.1; NM_001252010.1.
DR RefSeq; XP_016873140.1; XM_017017651.1.
DR AlphaFoldDB; Q86TE4; -.
DR SMR; Q86TE4; -.
DR BioGRID; 130772; 2.
DR IntAct; Q86TE4; 3.
DR STRING; 9606.ENSP00000336817; -.
DR GlyGen; Q86TE4; 3 sites.
DR iPTMnet; Q86TE4; -.
DR PhosphoSitePlus; Q86TE4; -.
DR BioMuta; LUZP2; -.
DR DMDM; 166232937; -.
DR MassIVE; Q86TE4; -.
DR MaxQB; Q86TE4; -.
DR PaxDb; Q86TE4; -.
DR PeptideAtlas; Q86TE4; -.
DR PRIDE; Q86TE4; -.
DR ProteomicsDB; 22310; -.
DR ProteomicsDB; 69688; -. [Q86TE4-1]
DR ProteomicsDB; 69689; -. [Q86TE4-2]
DR ProteomicsDB; 69690; -. [Q86TE4-3]
DR Antibodypedia; 64358; 99 antibodies from 17 providers.
DR DNASU; 338645; -.
DR Ensembl; ENST00000336930.11; ENSP00000336817.6; ENSG00000187398.12. [Q86TE4-1]
DR Ensembl; ENST00000533227.5; ENSP00000432952.1; ENSG00000187398.12. [Q86TE4-4]
DR Ensembl; ENST00000620308.1; ENSP00000480441.1; ENSG00000187398.12. [Q86TE4-4]
DR GeneID; 338645; -.
DR KEGG; hsa:338645; -.
DR MANE-Select; ENST00000336930.11; ENSP00000336817.6; NM_001009909.4; NP_001009909.2.
DR UCSC; uc001mqs.4; human. [Q86TE4-1]
DR CTD; 338645; -.
DR DisGeNET; 338645; -.
DR GeneCards; LUZP2; -.
DR HGNC; HGNC:23206; LUZP2.
DR HPA; ENSG00000187398; Tissue enriched (brain).
DR MIM; 608178; gene.
DR neXtProt; NX_Q86TE4; -.
DR OpenTargets; ENSG00000187398; -.
DR PharmGKB; PA28445; -.
DR VEuPathDB; HostDB:ENSG00000187398; -.
DR eggNOG; ENOG502QV95; Eukaryota.
DR GeneTree; ENSGT00390000013180; -.
DR HOGENOM; CLU_068900_0_0_1; -.
DR InParanoid; Q86TE4; -.
DR OMA; TTVCDSQ; -.
DR OrthoDB; 976560at2759; -.
DR PhylomeDB; Q86TE4; -.
DR TreeFam; TF331644; -.
DR PathwayCommons; Q86TE4; -.
DR SignaLink; Q86TE4; -.
DR BioGRID-ORCS; 338645; 14 hits in 1061 CRISPR screens.
DR ChiTaRS; LUZP2; human.
DR GenomeRNAi; 338645; -.
DR Pharos; Q86TE4; Tdark.
DR PRO; PR:Q86TE4; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q86TE4; protein.
DR Bgee; ENSG00000187398; Expressed in adrenal tissue and 108 other tissues.
DR ExpressionAtlas; Q86TE4; baseline and differential.
DR Genevisible; Q86TE4; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR026718; Luzp2.
DR PANTHER; PTHR22414; PTHR22414; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Glycoprotein; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..346
FT /note="Leucine zipper protein 2"
FT /id="PRO_0000315274"
FT REGION 164..192
FT /note="Leucine-zipper"
FT REGION 221..240
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 248..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 16..211
FT /evidence="ECO:0000255"
FT COMPBIAS 252..286
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 133
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 264
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 302
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..86
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_044970"
FT VAR_SEQ 133..159
FT /note="NKSLKNKLLSGNKLCGIHAEESKKIQA -> DSRKRPRDLQWKIVSMRTMSI
FT YLLMYL (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_030520"
FT VAR_SEQ 133..136
FT /note="NKSL -> VIQI (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_030521"
FT VAR_SEQ 137..346
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_030522"
FT VAR_SEQ 160..346
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:12975309"
FT /id="VSP_030523"
FT VARIANT 308
FT /note="E -> Q (in dbSNP:rs7930185)"
FT /id="VAR_038165"
SQ SEQUENCE 346 AA; 38958 MW; AC29F2D885EC3278 CRC64;
MKFSPAHYLL PLLPALVLST RQDYEELEKQ LKEVFKERST ILRQLTKTSR ELDGIKVNLQ
SLKNDEQSAK TDVQKLLELG QKQREEMKSL QEALQNQLKE TSEKAEKHQA TINFLKTEVE
RKSKMIRDLQ NENKSLKNKL LSGNKLCGIH AEESKKIQAQ LKELRYGKKD LLFKAQQLTD
LEQKLAVAKN ELEKAALDRE SQMKAMKETV QLCLTSVFRD QPPPPLSLIT SNPTRMLLPP
RNIASKLPDA AAKSKPQQSA SGNNESSQVE STKEGNPSTT ACDSQDEGRP CSMKHKESPP
SNATAETEPI PQKLQMPPCS ECEVKKAPEK PLTSFEGMAA REEKIL
