LUZP2_MOUSE
ID LUZP2_MOUSE Reviewed; 345 AA.
AC Q8BGY3; Q7TPB5; Q8CBZ7;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Leucine zipper protein 2;
DE Flags: Precursor;
GN Name=Luzp2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=C3H/F;
RX PubMed=12856284; DOI=10.1007/s00335-002-2248-6;
RA Wu M., Michaud E.J., Johnson D.K.;
RT "Cloning, functional study and comparative mapping of Luzp2 to mouse
RT chromosome 7 and human chromosome 11p13-11p14.";
RL Mamm. Genome 14:323-334(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Diencephalon, and Olfactory bulb;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expression found only in the brain and spinal cord.
CC {ECO:0000269|PubMed:12856284}.
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DR EMBL; AY164459; AAO26442.1; -; mRNA.
DR EMBL; AK032204; BAC27756.1; -; mRNA.
DR EMBL; AK034240; BAC28644.1; -; mRNA.
DR EMBL; AK034077; BAC28573.1; -; mRNA.
DR EMBL; BC075646; AAH75646.1; -; mRNA.
DR CCDS; CCDS39970.1; -.
DR RefSeq; NP_848820.4; NM_178705.5.
DR AlphaFoldDB; Q8BGY3; -.
DR SMR; Q8BGY3; -.
DR BioGRID; 231397; 1.
DR STRING; 10090.ENSMUSP00000080979; -.
DR GlyConnect; 2476; 3 N-Linked glycans (1 site).
DR GlyGen; Q8BGY3; 2 sites, 3 N-linked glycans (1 site).
DR iPTMnet; Q8BGY3; -.
DR PhosphoSitePlus; Q8BGY3; -.
DR MaxQB; Q8BGY3; -.
DR PaxDb; Q8BGY3; -.
DR PRIDE; Q8BGY3; -.
DR ProteomicsDB; 295730; -.
DR Antibodypedia; 64358; 99 antibodies from 17 providers.
DR DNASU; 233271; -.
DR Ensembl; ENSMUST00000082373; ENSMUSP00000080979; ENSMUSG00000063297.
DR GeneID; 233271; -.
DR KEGG; mmu:233271; -.
DR UCSC; uc009hcw.1; mouse.
DR CTD; 338645; -.
DR MGI; MGI:1889615; Luzp2.
DR VEuPathDB; HostDB:ENSMUSG00000063297; -.
DR eggNOG; ENOG502QV95; Eukaryota.
DR GeneTree; ENSGT00390000013180; -.
DR HOGENOM; CLU_068900_0_0_1; -.
DR InParanoid; Q8BGY3; -.
DR OMA; TTVCDSQ; -.
DR OrthoDB; 976560at2759; -.
DR PhylomeDB; Q8BGY3; -.
DR TreeFam; TF331644; -.
DR BioGRID-ORCS; 233271; 3 hits in 74 CRISPR screens.
DR ChiTaRS; Luzp2; mouse.
DR PRO; PR:Q8BGY3; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8BGY3; protein.
DR Bgee; ENSMUSG00000063297; Expressed in cerebellar cortex and 43 other tissues.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR026718; Luzp2.
DR PANTHER; PTHR22414; PTHR22414; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..345
FT /note="Leucine zipper protein 2"
FT /id="PRO_0000315275"
FT REGION 164..192
FT /note="Leucine-zipper"
FT REGION 223..345
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 16..211
FT /evidence="ECO:0000255"
FT COMPBIAS 251..266
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 294..316
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 133
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 301
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 26
FT /note="E -> Q (in Ref. 2; BAC28644)"
FT /evidence="ECO:0000305"
FT CONFLICT 243
FT /note="A -> G (in Ref. 1; AAO26442)"
FT /evidence="ECO:0000305"
FT CONFLICT 269
FT /note="Q -> R (in Ref. 1; AAO26442)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 345 AA; 39020 MW; 632AD00229EDB24E CRC64;
MKFNAAHYLL PLLPALVLST RQDYEELEKQ LKEVFKERST VLRQLTKTSR ELDGIKVNLQ
SLKNDEQSSK TDVQKLLELG QRQREEMKSL QEALQNQLKE TSEKAEKHQA TINFLKTEVE
RKSKMIRDLQ NENKSLKNKL LSGSKLCGIH AEESKKIQAQ LKELRYGKKD LLFKAQQLTE
LEQKLAVAKN ELEKAALDRE SQMKAMKETV QLCLSSVFRD QPPPLSLMPS NPTQMLHPPR
TVASRIPEAR TKSKPQPSSP GHHDSSQVQA TKEESRRPSV CGPQDEGSSC LVKHEEGPQS
NSTAESELTT QKLQMPICSE CEEKKGPENP SASFDGTPAR EEKLL
