ID   LUZP6_HUMAN             Reviewed;          58 AA.
AC   Q538Z0; K7EQW5;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=Leucine zipper protein 6;
DE   AltName: Full=Myeloproliferative disease-associated 6 kDa antigen;
GN   Name=LUZP6; Synonyms=MPD6;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], SYNTHESIS OF 39-58, TISSUE SPECIFICITY,
RP   INDUCTION, AND IDENTIFICATION AS A CANCER ANTIGEN.
RC   TISSUE=Testis;
RX   PubMed=16982933; DOI=10.4049/jimmunol.177.7.4907;
RA   Xiong Z., Liu E., Yan Y., Silver R.T., Yang F., Chen I.H., Chen Y.,
RA   Verstovsek S., Wang H., Prchal J., Yang X.-F.;
RT   "An unconventional antigen translated by a novel internal ribosome entry
RT   site elicits antitumor humoral immune reactions.";
RL   J. Immunol. 177:4907-4916(2006).
RN   [2]
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RX   DOI=10.4236/ojmn.2018.83021;
RA   Groll M., Frenzel J., Krause M., Schaenzer A., Mueller W., Eschrich K.,
RA   Nestler U.;
RT   "MALDI-TOF mass spectrometric analysis of brain tumor cyst fluid reveals a
RT   protein peak corresponding to ApoC1 and LuzP6.";
RL   O. J. Mod. Neurosurg. 8:251-263(2018).
CC   -!- TISSUE SPECIFICITY: Widely expressed, highest levels found in brain,
CC       placenta, spleen, testis, and ovary. Up-regulated in some tumor cells.
CC       {ECO:0000269|PubMed:16982933}.
CC   -!- INDUCTION: By IFNA1. {ECO:0000269|PubMed:16982933}.
CC   -!- MISCELLANEOUS: Elicits IgG antibody response in a subset of
CC       polycythemia vera patients and as well in patients with chronic
CC       myelogenous leukemia and prostate cancer receiving IFNA1 or other
CC       therapy, suggesting that it is broadly immunogenic.
CC   -!- MISCELLANEOUS: This protein is produced by a bicistronic gene which
CC       also produces the MTPN protein from a non-overlapping reading frame.
CC       LUZP6 belongs to a group of cryptic antigens without conventional
CC       genomic structure. It is encoded by a cryptic open reading frame
CC       located in the 3'-untranslated region of MTPN that is expressed
CC       following IRES-mediated alternative initiation of translation at a AUU
CC       start codon.
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DR   EMBL; AY611627; AAU14892.1; -; mRNA.
DR   EMBL; AC015987; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001122091.2; NM_001128619.2.
DR   AlphaFoldDB; Q538Z0; -.
DR   BioGRID; 612785; 1.
DR   STRING; 9606.ENSP00000468007; -.
DR   iPTMnet; Q538Z0; -.
DR   PhosphoSitePlus; Q538Z0; -.
DR   BioMuta; LUZP6; -.
DR   PaxDb; Q538Z0; -.
DR   PRIDE; Q538Z0; -.
DR   DNASU; 767558; -.
DR   GeneID; 767558; -.
DR   UCSC; uc064iig.1; human.
DR   CTD; 767558; -.
DR   DisGeNET; 767558; -.
DR   GeneCards; LUZP6; -.
DR   HGNC; HGNC:33955; LUZP6.
DR   MIM; 611050; gene.
DR   neXtProt; NX_Q538Z0; -.
DR   eggNOG; ENOG502TDMB; Eukaryota.
DR   HOGENOM; CLU_211826_0_0_1; -.
DR   InParanoid; Q538Z0; -.
DR   PathwayCommons; Q538Z0; -.
DR   BioGRID-ORCS; 767558; 13 hits in 922 CRISPR screens.
DR   ChiTaRS; LUZP6; human.
DR   GenomeRNAi; 767558; -.
DR   Pharos; Q538Z0; Tdark.
DR   PRO; PR:Q538Z0; -.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q538Z0; protein.
DR   Genevisible; Q538Z0; HS.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..58
FT                   /note="Leucine zipper protein 6"
FT                   /id="PRO_0000318578"
SQ   SEQUENCE   58 AA;  6437 MW;  565F242B0695373C CRC64;
     MKSVISYALY QVQTGSLPVY SSVLTKSPLQ LQTVIYRLIV QIQHLNIPSS SSTHSSPF