ID   LVGA_LEGPN              Reviewed;         208 AA.
AC   Q9RNG8; E1XUX1;
DT   25-MAY-2022, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 2.
DT   03-AUG-2022, entry version 44.
DE   RecName: Full=Type 4 adapter protein LvgA {ECO:0000305};
DE   AltName: Full=Virulence factor LvgA {ECO:0000303|PubMed:12704109};
GN   Name=lvgA {ECO:0000303|PubMed:12704109};
GN   ORFNames=DIZ50_12655 {ECO:0000312|EMBL:TIE45252.1};
OS   Legionella pneumophila.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Legionellales;
OC   Legionellaceae; Legionella.
OX   NCBI_TaxID=446;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION IN VIRULENCE, SUBCELLULAR
RP   LOCATION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=130b / Wadsworth / Serogroup 1;
RX   PubMed=12704109; DOI=10.1128/iai.71.5.2394-2403.2003;
RA   Edelstein P.H., Hu B., Higa F., Edelstein M.A.;
RT   "lvgA, a novel Legionella pneumophila virulence factor.";
RL   Infect. Immun. 71:2394-2403(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=POC1;
RA   Garner E.;
RT   "Whole genome sequence comparison of clinical and drinking water Legionella
RT   pneumophila isolates.";
RL   Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the Dot/Icm type IVB secretion system (T4BSS),
CC       which is used to inject bacterial effector proteins into eukaryotic
CC       host cells (By similarity). Part of a subcomplex which recruits
CC       effector proteins and delivers them to the core transmembrane
CC       subcomplex (By similarity). Is a critical subunit for binding a subset
CC       of effector proteins (By similarity). Recognizes more than one type of
CC       binding motif (By similarity). May be a critical factor that confers
CC       host specificity (By similarity). Necessary for full virulence of the
CC       bacterium in guinea pigs and presumably humans (PubMed:12704109).
CC       {ECO:0000250|UniProtKB:Q5ZY48, ECO:0000269|PubMed:12704109}.
CC   -!- SUBUNIT: The T4BSS is a complex nanomachine composed of several
CC       subcomplexes. This subunit is part of the Type IV Coupling Complex
CC       (T4CC), a subcomplex composed of the DotLMNYZ core and the IcmSW-LvgA
CC       adapter subunits, linked by the C-terminal tail of DotL.
CC       {ECO:0000250|UniProtKB:Q5ZY48}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5ZY48}. Note=At
CC       least some of the protein may be surface expressed.
CC       {ECO:0000269|PubMed:12704109}.
CC   -!- DISRUPTION PHENOTYPE: Shows attenuated virulence in guinea pigs. Mutant
CC       invades alveolar macrophages normally, but shows slower growth than
CC       wild-type strain. The mutant is twofold more susceptible to killing by
CC       human beta-defensin 2 but not to killing by other cationic peptides,
CC       serum complement, or polymorphonuclear neutrophils.
CC       {ECO:0000269|PubMed:12704109}.
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DR   EMBL; AF181867; AAF05324.2; -; Genomic_DNA.
DR   EMBL; QFHM01000010; TIE45252.1; -; Genomic_DNA.
DR   RefSeq; WP_027264756.1; NZ_UGOS01000001.1.
DR   OrthoDB; 1008152at2; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Cytoplasm; Protein transport; Transport; Virulence.
FT   CHAIN           1..208
FT                   /note="Type 4 adapter protein LvgA"
FT                   /id="PRO_0000455598"
FT   REGION          184..208
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   208 AA;  23527 MW;  E5F52D6FA8C59413 CRC64;
     MADGDIEIKA GFVDTDLDDR KLTMIDDLNN PLAIVERVYL IWWHWADFHL HVISPHIDTI
     TPAIVIEPEL ISGSNDHEFV YSIHDSGSKL STSKSQDMFS AGMSMCKLFY TIEKMVHILV
     DRLKSGGVSM EEEVQIAFAG HEIAQRKAFE SIINLPYNVV VTNFDPGIWG EKYLQNVKRL
     ADKGYGYPPE SPRENYKHPV SSATTARK