ID   LVSC_DICDI              Reviewed;        2491 AA.
AC   Q54U63; Q8IHK9;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   18-MAR-2008, sequence version 2.
DT   25-MAY-2022, entry version 112.
DE   RecName: Full=BEACH domain-containing protein lvsC;
GN   Name=lvsC; ORFNames=DDB_G0280971;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NC4A2;
RX   PubMed=12210762; DOI=10.1002/jcb.10254;
RA   Wang N., Wu W.I., De Lozanne A.;
RT   "BEACH family of proteins: phylogenetic and functional analysis of six
RT   Dictyostelium BEACH proteins.";
RL   J. Cell. Biochem. 86:561-570(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAN38986.1; Type=Miscellaneous discrepancy; Evidence={ECO:0000305};
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DR   EMBL; AY159039; AAN38986.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AAFI02000040; EAL66782.2; -; Genomic_DNA.
DR   RefSeq; XP_640913.2; XM_635821.2.
DR   AlphaFoldDB; Q54U63; -.
DR   SMR; Q54U63; -.
DR   STRING; 44689.DDB0233044; -.
DR   PaxDb; Q54U63; -.
DR   EnsemblProtists; EAL66782; EAL66782; DDB_G0280971.
DR   GeneID; 8622975; -.
DR   KEGG; ddi:DDB_G0280971; -.
DR   dictyBase; DDB_G0280971; lvsC.
DR   eggNOG; KOG1787; Eukaryota.
DR   HOGENOM; CLU_000307_0_0_1; -.
DR   InParanoid; Q54U63; -.
DR   OMA; EANQEEM; -.
DR   PRO; PR:Q54U63; -.
DR   Proteomes; UP000002195; Chromosome 3.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR   GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR   CDD; cd06071; Beach; 1.
DR   CDD; cd01201; PH_BEACH; 1.
DR   Gene3D; 1.10.1540.10; -; 1.
DR   Gene3D; 2.130.10.10; -; 2.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR000409; BEACH_dom.
DR   InterPro; IPR036372; BEACH_dom_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR   InterPro; IPR023362; PH-BEACH_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF02138; Beach; 1.
DR   Pfam; PF15787; DUF4704; 1.
DR   Pfam; PF14844; PH_BEACH; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM01026; Beach; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   SUPFAM; SSF81837; SSF81837; 1.
DR   PROSITE; PS50197; BEACH; 1.
DR   PROSITE; PS51783; PH_BEACH; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   4: Predicted;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..2491
FT                   /note="BEACH domain-containing protein lvsC"
FT                   /id="PRO_0000327709"
FT   DOMAIN          1701..1818
FT                   /note="BEACH-type PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01119"
FT   DOMAIN          1828..2118
FT                   /note="BEACH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00026"
FT   REPEAT          2259..2298
FT                   /note="WD 1"
FT   REPEAT          2311..2352
FT                   /note="WD 2"
FT   REPEAT          2354..2393
FT                   /note="WD 3"
FT   REPEAT          2394..2436
FT                   /note="WD 4"
FT   REPEAT          2438..2475
FT                   /note="WD 5"
FT   REGION          1095..1150
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1421..1441
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1620..1644
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1738..1761
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1740..1761
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   2491 AA;  283704 MW;  0EBEB60185D25F9D CRC64;
     MLDGIRQIIK NNPKKQNLFK KFRVFIKIVN LVNADDKKER LSVLCHSVLR TVILLMANNP
     KIKKHFRNHI GYDTIKDLII KSEGIVSETT MNILFDMIVD GEFDIEYKYV IQNPDSCLLI
     FNLLKYFPTK LQHEILDRFT VMVEKCTTNQ SVCCNCHLIY NLLEAIYKGQ PMEVTTKILK
     LIERLGIHSV TVRELKKLFG LLKSEQGDYL PPTTSALLTT LQNISNSRNP GPQVYFDFDG
     KDSCIILPTF DKWPFPKGFS FCTWVRIESF VDPTGTPEYK PRLFSFLSDS GCGIEVLFIY
     QQLQVLTVNN HQSKAVFQSP PTFVEREWYF VSVVYSINLI SSNEIRIYIN GQQSAKSSIK
     LNISGTLWNH FKIGNNSKKM SGERECPLYG QMGAFNIFDE SLSPSQIQAI YTLGPNFNTS
     FQDVEGSTKS AHTFESSLTS HLFLNYNCRA LDGDLCLDNT PDIGGDKNYD ATLVSINPCV
     SRDIKDIIYC LGGIKVLFPL IQQINNPISP LSLELITNEN NNNNNNNLSL SSQQQTLEQL
     QQSINIKLTN QVLALFKFML KESEANQEEM LRCQGFSVMG YLLQQISPEY LTIGCTNIFI
     DMSNQISDPT LVEEVYSNLM LNFCIWIKTK YELQRNLLVI IKQIVFEKYD QVSDIITVQL
     ILDIMNDFYW YDDSKNEAHR NHHFFNKDIL SKRPSISNIR ELRQILFEVL RILLRHQKST
     DIQAIIKFLI YCKDYQQLIE MMEFVLGLNG NGHNCQQFFD EIMGLGGTDV FLTLLKIDDE
     GVRNTAIQLI SKIHGLCNHS QNKKHKANLF QDSIIITRCL HTFPMTEETF RYLLSFAMGY
     DFTPANSTSH NNGQMVPPCL DKHKVIKNNE ILSVIFKLLS NTDVILVQTV LQEIKLYISN
     EESSHVNRNA CLSIDKWFDH LFAIISSVEK TDTQYSNVTD LIIDIIKILV IHSFDESKGI
     QKTLEIVLAT LRPYDERGVL DYHSLARTLF LNIVQSIKSK ALTTIGDNQS PLKKSKKAFI
     ENLIQFFILT EEFIFYSPKG GNHDLHSSLS SIRTSILGGG GGFNEFGIGS STIVTSSAHS
     ASSSVHSSFD GSFSPSSPQL LSSSTSSTSQ LQQQQQLQQL QQLQQQGQSK SGSNTPSNSN
     HGSYNYNNNN SPNLISSSNS LLNSPSSIGQ SLSSSFSLSS SSKEVNIGGG GGIGGFSKLH
     YNSETKEWED TLLVKEILDL VDTLKLLDNL SESDFSTSNI QATTSKSTSN LMFTTHYHRI
     FLRFTLEAIK ICNKQEPLQT LMSHVMRLKT LSEKDRQKVE NDTMSNNRLT FILSHLAKAL
     RSIIDLNLPL HQKALVPLMK DIIRKLNSTL ISTLSKQQQQ QQQQQQQQQQ QQQQQQQQQI
     HQHQSVSGPL NLYQLSLPQS ALSQSQQFII QQTQQILNGV GVGAGNSSPS SSSSSSSNSV
     NIDQSEISGW VEELTDSSRI VEFCSIVVTS PRWSQIVQYI DNQTYFTTVE EKSLYSWLEK
     RKKKLTKVVL NTDEKEAESF NAAERKADND LNSIHVKLWM PECERRALHL YKARELRNQT
     TVQWRKILRS LTNERGPWGT TESIVHWKLD KTENSSRMRI KLKRNYKFDE HLNCAINDSE
     IQDDHNNSNS NNNNDSNNSD GEHLSESANL LSIKPNEKQQ QQQQSDEVDS DWTMVPKDID
     SEENIDSLIQ QQQQQQHQQQ KEKEKLIYST SCHWITPSSC KKGKLEITTF NLIFTEEEEL
     PPPSTTTTNT TNTTNTNSTT NDSTFLKIKR WPNEMIKDVH LRRYLLRGSA IEIFMRDKTN
     YLFNFKKNER NKVYNKINSV KREFSKEPTL SPSDMLKKAT SEWQARRISN FDYLMTLNTI
     AGRTYNDLTQ YPVFPWVIAD YTSPVLDLNK AETFRDLSKP IGALNEKRLE IFKDRYESFD
     DPVIPKFYYG SHYSSAGIVL FYLIRLEPFT TQFLNLQGGR FDHPDRMFDS IALAWDNSLT
     SSTDVKELIP EFYYMPEFLT NHNHINFGIK QNGIGIEDVL LPPWASSPSD FIRINREALE
     SDYVSSHLHE WIDLIFGIKQ RGKQAKEVFN VFYYLTYEGS VDIDSIEDET TRRATESQIN
     NFGQTPTQLF SKKHHIQRDP LNESHISILK TPPNQLQAYF LKITNKNPIV YVYIPEPNPI
     MSYLVADKVT VIDKSRTTTN HKWFPSTPND KISPFTFELD PSSTTKRRIG LPFANDVTIS
     PNCFAITSDG RYVISCAHWD NSFKLSFVDS AKLIQSVVKH KDTVTCLSLA SDGQTLITGS
     KDTTVMVWRI ATTNKSGAPK FNDVPDHILY GHDDEITCVD VNVGLDISIS GSKDGTCIIH
     NLKHGEYVRS IYLPRQSPIS LIAISNQGYI VIYSQADLMI YLYSINGGLL KTVDTHERLH
     SIIISKDSEY LITGGERGVV VIRTLFNLKP TNHKLVFGTP IHSLAMASDQ KHLMVGLEDG
     RLLIIASNSA SPPTNYYSIT KFLIFITFII Q