LVSD_DICDI
ID LVSD_DICDI Reviewed; 2967 AA.
AC Q55AV3; Q55AV2; Q8IHK8;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-SEP-2011, sequence version 2.
DT 23-FEB-2022, entry version 100.
DE RecName: Full=BEACH domain-containing protein lvsD;
GN Name=lvsD; ORFNames=DDB_G0271502;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 363-2967.
RC STRAIN=NC4A2;
RX PubMed=12210762; DOI=10.1002/jcb.10254;
RA Wang N., Wu W.I., De Lozanne A.;
RT "BEACH family of proteins: phylogenetic and functional analysis of six
RT Dictyostelium BEACH proteins.";
RL J. Cell. Biochem. 86:561-570(2002).
CC -!- SEQUENCE CAUTION:
CC Sequence=AAN38987.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EAL71615.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EAL71686.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AAFI02000006; EAL71615.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AAFI02000006; EAL71686.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AY159040; AAN38987.1; ALT_SEQ; Genomic_DNA.
DR RefSeq; XP_645593.1; XM_640501.1.
DR RefSeq; XP_645594.1; XM_640502.1.
DR SMR; Q55AV3; -.
DR STRING; 44689.DDB0185108; -.
DR PaxDb; Q55AV3; -.
DR EnsemblProtists; EAL71615; EAL71615; DDB_G0271502.
DR EnsemblProtists; EAL71686; EAL71686; DDB_G0271644.
DR GeneID; 8618048; -.
DR GeneID; 8618049; -.
DR KEGG; ddi:DDB_G0271502; -.
DR KEGG; ddi:DDB_G0271644; -.
DR dictyBase; DDB_G0271502; lvsD.
DR eggNOG; KOG1787; Eukaryota.
DR InParanoid; Q55AV3; -.
DR PRO; PR:Q55AV3; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0005829; C:cytosol; IDA:dictyBase.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR GO; GO:0033298; P:contractile vacuole organization; IGI:dictyBase.
DR GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR GO; GO:0030587; P:sorocarp development; HMP:dictyBase.
DR CDD; cd06071; Beach; 1.
DR Gene3D; 1.10.1540.10; -; 1.
DR Gene3D; 2.130.10.10; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF15787; DUF4704; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 2.
DR SUPFAM; SSF49899; SSF49899; 1.
DR SUPFAM; SSF50978; SSF50978; 1.
DR SUPFAM; SSF81837; SSF81837; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 4: Predicted;
KW Reference proteome; Repeat; WD repeat.
FT CHAIN 1..2967
FT /note="BEACH domain-containing protein lvsD"
FT /id="PRO_0000327710"
FT DOMAIN 229..?491
FT /note="BEACH 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00026"
FT DOMAIN 2060..2162
FT /note="BEACH-type PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01119"
FT DOMAIN 2202..2492
FT /note="BEACH 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00026"
FT DOMAIN 2628..?2785
FT /note="BEACH 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00026"
FT REPEAT 2658..2710
FT /note="WD 1"
FT REPEAT 2720..2761
FT /note="WD 2"
FT REGION 1..25
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 322..364
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 588..615
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 917..936
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1077..1105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1173..1220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1583..1613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1831..1859
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1921..2009
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2029..2062
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2798..2820
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2915..2934
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..24
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1077..1095
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1206..1220
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 395
FT /note="Y -> D (in Ref. 3; AAN38987)"
FT /evidence="ECO:0000305"
FT CONFLICT 550..647
FT /note="Missing (in Ref. 3; AAN38987)"
FT /evidence="ECO:0000305"
FT CONFLICT 764
FT /note="E -> K (in Ref. 3; AAN38987)"
FT /evidence="ECO:0000305"
FT CONFLICT 785
FT /note="R -> I (in Ref. 3; AAN38987)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 2967 AA; 335927 MW; 2D3F5339E13932EA CRC64;
MSSPLKFPFK QQQQQQQQQR SRIGGDDIMN KLENEKYIVK QLFEQLLGYD NNSSFSNSNN
LRITNQINNL FNGNYDPTEQ DRFIIKNFTK IHEIILLLKD EEISSFIKIK ILDQLIQILS
YSSNNTINLI QSTSPINNNN NRKSKTLYTN KSLVILDELI QMLPSIDNEQ ISLKTLQLIE
ILGTEHITVK QLRKLLKLFD RNYLLTNFKP NHYFLQNGLP NLMKSLDVMT FRKAPSSVFY
MNGINSGLIV DPIGKISTSG YTISTWINIE SFQHESEFIR SYEPRLFSFL NDGGSAGIEG
YFENSKFVIR INEKVKAIVN LNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNS
SSNSDFPTNK WCHLLVTQSP KKWGLYPGNT TLNIYLDGKL VHTQQIKYPS TSKNLNICSI
GTVPSGSVPS NNSGFTYISS PSSPFSLSSS SSGGNNQSEC CLKCQMGSFS MLSTFYDNSD
VQDLFRKGSN YILKKQKNVQ FTFSPKSFYG GVCHGLGNRE LDNSINAFSI GDLKIFSTFS
IKDSIYLIGG PQIIFPLLQA IEDQFKFITP ITLSPNLLSS SSSSSSSILS IDPNNNNNNN
NNNNNNIQQP QQQQLQLNEE ETINTNNNIK LTSSQSTDNI VVFNGSQEDI NQLSKLINYP
RISSILRFIT HLLINDKYNQ KELIGSNGLS LLGYLISNIF SNSDSNPSHP YNFKTLEREE
FDLIFDALDQ LTDFSLVDKN PLLKLNIYKE IIFNFNIWVH IKKEYQIQLF NLIIFKVSQN
PQYFRENIKV RYLLDCIKYF YHINENTIIS TNNNNNNNNI GESSGANNNN NNNNNNTNNV
GNCRLNCHLS NQDLKEIISY IFDIIKIIIK PILNEKEVPE IQEIIKFIQD SECNSTVIKE
SLMILLSNLF LPVNNNNNSN NNNNNNNSNS NNNNINIGGD EKFQNYDTIK GFLNSFESSG
DIKSLLGLLK HNNEQVQVLV IKIIGKYMGG SEGLSMASSG NVRRSLKLKN TLTDVLYFIT
DQLMEFEMTE LMYRGLSEIV VDEITPSIAD TPNSPLLELL GSETLLADSI SSVNIMGGSN
NNNNNNNNNS NNNKDKIDSN NKDKDSKEKR IINIAALETI CRLAIRAPLA LQQKILNEIL
LCIKHLPQMR AGILDSENWQ HWLLSLWPQP RSNTSSPPWS PPISPLLTST KSMSPSPPPP
PPLSSSSYQQ QQQNIISDHR SQTKEQLSIR AYQSGIKEIL TGIMKVLLFD CINKKDGWKF
IEETEAWIFS ILPNGVPLER RIFYECLLNL ERGLKSSNHD PTTGGILLKN YVNLVSIIED
FVFSHTMNIL AHRNTQSQWE DFGVVAKLLD IFDISQSIQT IRIQANVVKP TASSSLNPFS
SNHSNYQSPY GSMQFSPYIM TLANNSGTID LPSIDVTSGS AKAKSSIHTI YRLCLCIFQE
AESCFYGERE SYHQSKHDHT NENADDEERQ FSIRVWGLPM ISEDMDHIIS KNSIRIQTIL
ASERDQKEQV KHVMWIVCSL ITIIRRHKTN NEDKIIINTQ SIIISLLKQL LKTYGDLIDN
FINPPSNILS PIINSVVGGG NNNNNSGNNN SGNNINNNNN NNNNNTNLNN NENEKTSFSV
HSISSLNEKT DLINHPEFLK YFNDKLLPKI TLLDKLHEIK DHYENAHLQS AFTMTRRNKV
LEAINSNYQK HQNVITYKIN KLLTKSISTS QKYEFQEIQR KSDFQEYIQQ YNQYIIDLWN
TKFKQLTQQE SSPWFQMEPN HNEKTIWRLY NISNSNRVNI LMKKDYDGTD HPEASLSNQK
ILRQQQLRME QQQQLRLEQQ QQKLQQQQQQ QQQQQQSQQS LQLPPSPSIS NAGSSSSVVE
QLKNNPILRK VTKHTTSTDS LGNDTLVGFE IEEKDDDGNN IILDDEHESE WCLVDEKIMK
PQKTPQNQHQ QQQAQQQHQQ QQQQHQFKRS TSLSANQTLL NTSSTSSLSS SSSPSSSFSN
IQTVTNSGGG GTNIITTTTT TTTTSTLNND RVNSNFNLFE QLNLLNPKKS TLTSSSSSSP
SSNNNNGNSN NNSNNNNNNN KNIKLEFSTQ GEIIKPMSVI RIKLQIFTDR LILTSNLIQE
DDCIPPKYLK DREYEIKKII GVQCRRYLLS PTALEFFFID RKSLLVNFPR GSICAQILKL
IGNLYGSNDI IFKINTNNVS FFDGTIGANN STNNSNSNQP MTPQQVVIKY LNPTARWKRR
EISNFEYLMT LNTIAGRTYN DLNQYPVFPW IIGDNSSNTL NINDQSIYRD LSKPIGALNP
TRLELFMERW TQCPAEIPAF MYGTHYSSSG SVMFFLMRCE PFTSHFIKLQ SGHFDHADRM
FDSIIDCWRN CLNSSSDVKE LTPEFFYLPE FLINRNRVEF GVKQNGKALD NVSLPPWAQQ
SPYHFIMLNR MALESEYVSM NLHHWIDLIF GYKQRGKEAV KANNVFYHLT YEGSVDIGAM
NDPILREATR VQINNFGVTP SQLFPNQPHP QRDPLPQRYS NKLDIFKRLK PLQLISLPFS
PLCIFVYCPT KSDYYSGGIG SSLISGVVGN SSSANSLLGD RVLLIGEANN DLQYYRYLES
TSTISTQTST NLVSQSVQPL PSNANQPITL SSGLRSVIGK PFCQIPSNSR VLLTSGKCDY
TLHIVHGEGS KLVTGSINHK SPITCIVYDE YQCGRLGVGG VLIEQKVIVT GSDDSTAIVW
EYEQSQSDHH SIKPIHILRG HNFGITCIAI NKANDICLTA SKDGKVNVHS LKKGTFFKSI
QHPNKLPIHS IILENDSSTF FIYSNSILPI VQSDYNSSAT TTTTTRDDES SSSSLSSSNT
TISNNNVLYR YSINGDLIQS VQNDVQPIIV KMLITKSQNG IRYLLTAGGY QIVIREMLNL
EIVHVFDIRD LSGFTNSNKI VDIYLWGGDE SYQKPSTSVS GDSNSNNNNN NNGNNTINNN
LTLMVPLESC QLLIYSFDEF GNLKSLD
