ID   LVSE_DICDI              Reviewed;        2192 AA.
AC   Q54RQ8; Q8IHL2;
DT   08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   24-MAY-2005, sequence version 1.
DT   25-MAY-2022, entry version 107.
DE   RecName: Full=BEACH domain-containing protein lvsE;
GN   Name=lvsE; ORFNames=DDB_G0282925;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=NC4A2;
RX   PubMed=12210762; DOI=10.1002/jcb.10254;
RA   Wang N., Wu W.I., De Lozanne A.;
RT   "BEACH family of proteins: phylogenetic and functional analysis of six
RT   Dictyostelium BEACH proteins.";
RL   J. Cell. Biochem. 86:561-570(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
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DR   EMBL; AY159036; AAN38983.1; -; Genomic_DNA.
DR   EMBL; AAFI02000049; EAL65906.1; -; Genomic_DNA.
DR   RefSeq; XP_639293.1; XM_634201.1.
DR   AlphaFoldDB; Q54RQ8; -.
DR   SMR; Q54RQ8; -.
DR   STRING; 44689.DDB0191473; -.
DR   PaxDb; Q54RQ8; -.
DR   EnsemblProtists; EAL65906; EAL65906; DDB_G0282925.
DR   GeneID; 8623864; -.
DR   KEGG; ddi:DDB_G0282925; -.
DR   dictyBase; DDB_G0282925; lvsE.
DR   eggNOG; KOG1787; Eukaryota.
DR   eggNOG; KOG3388; Eukaryota.
DR   HOGENOM; CLU_231322_0_0_1; -.
DR   InParanoid; Q54RQ8; -.
DR   OMA; RCHIGNS; -.
DR   PRO; PR:Q54RQ8; -.
DR   Proteomes; UP000002195; Chromosome 4.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR   GO; GO:0043327; P:chemotaxis to cAMP; HMP:dictyBase.
DR   GO; GO:0008104; P:protein localization; IBA:GO_Central.
DR   CDD; cd06071; Beach; 1.
DR   CDD; cd01201; PH_BEACH; 1.
DR   Gene3D; 1.10.1540.10; -; 1.
DR   Gene3D; 2.130.10.10; -; 1.
DR   Gene3D; 2.30.29.30; -; 1.
DR   InterPro; IPR000409; BEACH_dom.
DR   InterPro; IPR036372; BEACH_dom_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR   InterPro; IPR003115; ParB/Sulfiredoxin_dom.
DR   InterPro; IPR036086; ParB/Sulfiredoxin_sf.
DR   InterPro; IPR023362; PH-BEACH_dom.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   Pfam; PF02138; Beach; 1.
DR   Pfam; PF15787; DUF4704; 1.
DR   Pfam; PF02195; ParBc; 1.
DR   Pfam; PF14844; PH_BEACH; 1.
DR   SMART; SM01026; Beach; 1.
DR   SMART; SM00470; ParB; 1.
DR   SMART; SM00320; WD40; 2.
DR   SUPFAM; SSF110849; SSF110849; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   SUPFAM; SSF81837; SSF81837; 1.
DR   PROSITE; PS50197; BEACH; 1.
DR   PROSITE; PS51783; PH_BEACH; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 1.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   4: Predicted;
KW   Reference proteome; Repeat; WD repeat.
FT   CHAIN           1..2192
FT                   /note="BEACH domain-containing protein lvsE"
FT                   /id="PRO_0000327711"
FT   DOMAIN          1366..1491
FT                   /note="BEACH-type PH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01119"
FT   DOMAIN          1504..1795
FT                   /note="BEACH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00026"
FT   REPEAT          1973..2012
FT                   /note="WD 1"
FT   REPEAT          2022..2061
FT                   /note="WD 2"
FT   REPEAT          2156..2192
FT                   /note="WD 3"
FT   REGION          948..969
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          996..1065
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1160..1303
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1343..1363
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1823..1851
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        996..1055
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1347..1363
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        1297
FT                   /note="N -> NNN (in Ref. 1; AAN38983)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   2192 AA;  248127 MW;  2C5F52BFAF0A5995 CRC64;
     MSVYTQLISV TEMPMSVIHR PLPSELDEEK VLSLMETIKS GVEIPPIDVN WVKGKDENNN
     YYFSFGGCHR YEATKRLNLK TIRARIIKST PSDIKVSPRL AQLPSDQSNY NMERLYVQDI
     FSKIKNKNQP DLSDLIILFD RLTSLAYQDV HSSKKVKFDY FYMFFNIMLD SPILSVTEST
     GNRVLHLLLL KKLNGLLFSN VLIQNYCHNE KWVYKLLNYL ISRSKHDSDV IGELSITLQI
     ICSFNITTKE LKYFFKLLES INEERPYYWN VLIEILQFLF RKRVGPDIYF NFSNSNGGLM
     VPDKQPFDGG YSISFWMNTD DFTSLKYRPG LFSFFSDENV GFEVTFQQQS LIFQIRTKSK
     SPCIGSHYRF QPGKWYHVII SHEYFLLRKS QLSLYVNGKL EEKMPLLYPK SDRPFTRCHI
     GNSVSLQNGF LGRIGSILMI KDALEPAEAT LLYQIDKNST MLQEKVPKEG MTAIYDSQLF
     LASGRRNIPI IFTYHPRATD KALCFEISSG ELPNAATIMD GVSILKSVSP LDQLVYIGGL
     KMIYPLFAQL GQPINGVEIE MPQDISDHMT TSPLPLSNLN DFISIPSSSG PTPIFPSSIG
     SGHSSCLFKI LLSLLQHHPA FREQIIETHG FQVISFLLKS TPTSSPYWTP DDIDSLSRLI
     SFCAGKQPLW SLAIQNLIMN NFQLWSQTNS LTQIALFETI HQRIQTNPQF WRNLVRVDQW
     LTILRKFYQL PSASSLSPLS LSSNSSSLSA SLSPIINSGS WCKESIEKPI FKDLPTIEKI
     KKARVQIIVI IRETAQPRLS PSETRWLSLY LKESTIENHD DVIRMLEDII QPLQSKDTWW
     DDVMASANLQ DENLVLKSRK DFQSTQTKLP SHISYLWDID CCEEVVKRLE EIKYQDRSNL
     ILFKHWVHIR RVRAGNLNGI KTRLTNGNQT NTPILTKLKQ MGIIQSPSTS LSTSSITPPP
     PNSRNTSTGI LKNSSIKEKQ LFQSNIDSLS FSLKETTTTT TTTTTTTTTS TTSNTGNDSP
     LSIESPISSP VLIENTTNTT NTTTTNTTNS SMLSIKDYDD GDEPEDTTVV HWKLDRTEGP
     LRMRRKLKRN YFGSDYKGLS KQNRFGRSRR TTLEKYSNEI ETFYIDQDCG DGLGNIIITI
     VNEPPLPHQT TSYKEIEFFN ESQSQSSSSS NIDNLNPNTG LPYNKSTNNL SNVNNVNNNN
     NNNSNNINVS GNNTIGPSSS KSPLRNSRSM SIGSSATKSP SRQNVKDVFN LDNNNSNSNN
     NNSNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNFNN NLSPTLNSIL PNLNNISINS
     GSNTIGPNSS MSSILSPRIG EFDENGVDVS SPNSSSLSSS SSNNQIEEEK FIGSWRCQMV
     VPVGVIPGQF TITSHYLTFD KDIQIVDQRT GRTFSPSLNG IQQQQQQQQD QDFGSVKIKN
     TYIWKVKDLV EIHRVRYLLR WNSIEIFLNH KSYMINFSKE QESIQIFNKI VALHPPNLRV
     KWSDHPSKII KKSKLTMKWK NREISNFEYL MSLNTIAGRT YNDISQYPVF PQIISDYKSE
     FLDLNDSRSF RDLSKPMGAL NQQRLDTLIK RYQSMQSAQD PTMPPFLYGS HYSNFGIVAY
     YQVRLEPFTS FHLSLQSGVF DHPQRMFESM DKMWDGVSGN NLADVKELIP EFFYMPEFIN
     NGEGFNFGFT NSKSGDLILP NWAHQSPELF IQINREALES EYVSMNLHHW IDLIFGFKQN
     GPAAQEANNV FFHLTYENNA ALQRDDPDER QSIASQIKEF GQTPPQLFSK PHPIRKTLQE
     ISKPQKDLFA RIAQNLFSPS NNGTINSSFS STSTSTSTSS PPPSTLNSPQ GPSLQYPFKV
     LKTKSSLPLV HISSCQDSDI VVLVYRDGVM AVNQFVPSPN GNLPFTFDID KTLSTYKEKQ
     IDTLFMSDSV TCISNCFAIT PDGKFMFSCA TWDSVFKCSN IQNGRVHRLY RDFHHDMVTC
     ISLGSNGKHF ATASSDTTIL VWNDVDHLIK DSKAKPSYRL CSHDEPVHCL DINEEWDLIA
     SGSMDKKLIL HSLGKGHYQR SMIHNGAVEI VKISTVGQTI ISYCSMSFLY VHSFNGKLLK
     IQQSDEKIYD AKLTGESVKK GGVLGVGSST QYLVTGGTRG VKVRSLPDLN IVHAFDSPAA
     IKTIELVAHE KYMLIGLNDG NLVIIPFDVK DL