LWA_ACTEQ
ID LWA_ACTEQ Reviewed; 164 AA.
AC Q16998;
DT 19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 45.
DE RecName: Full=LWamide neuropeptides;
DE Contains:
DE RecName: Full=LWamide I;
DE Contains:
DE RecName: Full=LWamide II;
DE Contains:
DE RecName: Full=LWamide III;
DE Contains:
DE RecName: Full=LWamide IV;
DE Contains:
DE RecName: Full=LWamide V;
DE Contains:
DE RecName: Full=LWamide VI;
DE Contains:
DE RecName: Full=Metamorphosin A;
DE Short=MMA;
DE Contains:
DE RecName: Full=MWamide;
DE Flags: Precursor; Fragment;
OS Actinia equina (Beadlet anemone).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Actiniidae; Actinia.
OX NCBI_TaxID=6106;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Gajewski M., Leitz T., Schlossherr J., Plickert G.;
RT "LWamides from Cnidaria constitute a novel family of neuropeptides with
RT morphogenetic activity.";
RL Roux's Arch. Dev. Biol. 205:232-242(1996).
CC -!- FUNCTION: Metamorphosin A may be part of an internal signaling system
CC involved in control of metamorphosis. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the LWamide neuropeptide family. {ECO:0000305}.
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DR EMBL; X89735; CAA61887.1; -; mRNA.
DR AlphaFoldDB; Q16998; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE 2: Evidence at transcript level;
KW Amidation; Cleavage on pair of basic residues; Neuropeptide; Repeat;
KW Secreted.
FT PROPEP 1..6
FT /evidence="ECO:0000255"
FT /id="PRO_0000010009"
FT PEPTIDE 7..11
FT /note="LWamide I"
FT /evidence="ECO:0000255"
FT /id="PRO_0000010010"
FT PEPTIDE 15..20
FT /note="LWamide II"
FT /evidence="ECO:0000255"
FT /id="PRO_0000010011"
FT PROPEP 23..27
FT /evidence="ECO:0000255"
FT /id="PRO_0000010012"
FT PEPTIDE 28..32
FT /note="LWamide I"
FT /evidence="ECO:0000255"
FT /id="PRO_0000010013"
FT PEPTIDE 36..41
FT /note="LWamide II"
FT /evidence="ECO:0000255"
FT /id="PRO_0000010014"
FT PROPEP 44..49
FT /evidence="ECO:0000255"
FT /id="PRO_0000010015"
FT PEPTIDE 50..53
FT /note="LWamide III"
FT /evidence="ECO:0000255"
FT /id="PRO_0000010016"
FT PEPTIDE 57..62
FT /note="LWamide II"
FT /evidence="ECO:0000255"
FT /id="PRO_0000010017"
FT PROPEP 65..70
FT /evidence="ECO:0000255"
FT /id="PRO_0000010018"
FT PEPTIDE 71..74
FT /note="LWamide III"
FT /evidence="ECO:0000255"
FT /id="PRO_0000010019"
FT PEPTIDE 78..83
FT /note="LWamide II"
FT /evidence="ECO:0000255"
FT /id="PRO_0000010020"
FT PROPEP 86..90
FT /evidence="ECO:0000255"
FT /id="PRO_0000010021"
FT PEPTIDE 91..95
FT /note="Metamorphosin A"
FT /id="PRO_0000010022"
FT PEPTIDE 99..106
FT /note="MWamide"
FT /evidence="ECO:0000255"
FT /id="PRO_0000010023"
FT PEPTIDE 110..115
FT /note="LWamide IV"
FT /evidence="ECO:0000255"
FT /id="PRO_0000010024"
FT PROPEP 118..123
FT /evidence="ECO:0000255"
FT /id="PRO_0000010025"
FT PEPTIDE 124..127
FT /note="LWamide V"
FT /evidence="ECO:0000255"
FT /id="PRO_0000010026"
FT PEPTIDE 131..137
FT /note="LWamide VI"
FT /evidence="ECO:0000255"
FT /id="PRO_0000010027"
FT PROPEP 140..164
FT /evidence="ECO:0000255"
FT /id="PRO_0000010028"
FT REGION 1..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 11
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 20
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 32
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 41
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 53
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 62
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 74
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 83
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 95
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 106
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 115
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 127
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 137
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT VARIANT 162
FT /note="S -> N"
FT NON_TER 1
SQ SEQUENCE 164 AA; 18395 MW; 4810617492A7093B CRC64;
RSADAQQHGL WGKRQNPGLW GRSADAQQHG LWGKRQNPGL WGRSAEPGQP GLWGKRQNPG
LWGRSAEPLQ PGLWGKRQNP GLWGRSADAQ QPGLWGKRQD LDIGMWGKRQ KAGLWGRSAD
PGQLGLWGKR RSRIGLWGRS YEPPQFEDLE DLKKKSAIPK PSEQ
