LWA_ANTEL
ID LWA_ANTEL Reviewed; 514 AA.
AC Q16992;
DT 19-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 54.
DE RecName: Full=LWamide neuropeptides;
DE Contains:
DE RecName: Full=LWamide I;
DE Contains:
DE RecName: Full=Metamorphosin A;
DE Short=MMA;
DE AltName: Full=LWamide II;
DE Contains:
DE RecName: Full=LWamide III;
DE Contains:
DE RecName: Full=LWamide IV;
DE Contains:
DE RecName: Full=LWamide V;
DE Contains:
DE RecName: Full=LWamide VI;
DE Contains:
DE RecName: Full=LWamide VII;
DE Contains:
DE RecName: Full=LWamide VIII;
DE Contains:
DE RecName: Full=LWamide IX;
DE Flags: Precursor;
OS Anthopleura elegantissima (Green aggregating anemone) (Actinia
OS elegantissima).
OC Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria;
OC Actiniidae; Anthopleura.
OX NCBI_TaxID=6110;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8524821; DOI=10.1073/pnas.92.25.11647;
RA Leviev I., Grimmelikhuijzen C.J.P.;
RT "Molecular cloning of a preprohormone from sea anemones containing numerous
RT copies of a metamorphosis-inducing neuropeptide: a likely role for
RT dipeptidyl aminopeptidase in neuropeptide precursor processing.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:11647-11651(1995).
RN [2] {ECO:0000305}
RP PROTEIN SEQUENCE OF METAMORPHOSIN A, AND FUNCTION.
RX PubMed=7911112; DOI=10.1006/dbio.1994.1160;
RA Leitz T., Morand K., Mann M.;
RT "Metamorphosin A: a novel peptide controlling development of the lower
RT metazoan Hydractinia echinata (Coelenterata, Hydrozoa).";
RL Dev. Biol. 163:440-446(1994).
CC -!- FUNCTION: Metamorphosin A may be part of an internal signaling system
CC involved in control of metamorphosis. {ECO:0000269|PubMed:7911112}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the LWamide neuropeptide family. {ECO:0000305}.
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DR EMBL; U34781; AAC46998.1; -; mRNA.
DR AlphaFoldDB; Q16992; -.
DR SMR; Q16992; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005643; C:nuclear pore; IEA:UniProt.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR InterPro; IPR025574; Nucleoporin_FG_rpt.
DR Pfam; PF13634; Nucleoporin_FG; 2.
PE 1: Evidence at protein level;
KW Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW Neuropeptide; Repeat; Secreted; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT PROPEP 23..75
FT /evidence="ECO:0000255"
FT /id="PRO_0000009951"
FT PEPTIDE 76..81
FT /note="Metamorphosin A"
FT /evidence="ECO:0000269|PubMed:7911112"
FT /id="PRO_0000009952"
FT PEPTIDE 85..90
FT /note="LWamide IV"
FT /evidence="ECO:0000255"
FT /id="PRO_0000009953"
FT PROPEP 93..97
FT /evidence="ECO:0000255"
FT /id="PRO_0000009954"
FT PEPTIDE 98..102
FT /note="LWamide III"
FT /evidence="ECO:0000255"
FT /id="PRO_0000009955"
FT PEPTIDE 106..111
FT /note="LWamide VII"
FT /evidence="ECO:0000255"
FT /id="PRO_0000009956"
FT PROPEP 114..118
FT /evidence="ECO:0000255"
FT /id="PRO_0000009957"
FT PEPTIDE 119..123
FT /note="LWamide III"
FT /evidence="ECO:0000255"
FT /id="PRO_0000009958"
FT PEPTIDE 127..132
FT /note="LWamide I"
FT /evidence="ECO:0000255"
FT /id="PRO_0000009959"
FT PROPEP 135..139
FT /evidence="ECO:0000255"
FT /id="PRO_0000009960"
FT PEPTIDE 140..144
FT /note="LWamide III"
FT /evidence="ECO:0000255"
FT /id="PRO_0000009961"
FT PEPTIDE 148..153
FT /note="LWamide I"
FT /evidence="ECO:0000255"
FT /id="PRO_0000009962"
FT PROPEP 156..160
FT /evidence="ECO:0000255"
FT /id="PRO_0000009963"
FT PEPTIDE 161..165
FT /note="LWamide III"
FT /evidence="ECO:0000255"
FT /id="PRO_0000009964"
FT PEPTIDE 169..174
FT /note="LWamide I"
FT /evidence="ECO:0000255"
FT /id="PRO_0000009965"
FT PROPEP 177..181
FT /evidence="ECO:0000255"
FT /id="PRO_0000009966"
FT PEPTIDE 182..186
FT /note="LWamide VI"
FT /evidence="ECO:0000255"
FT /id="PRO_0000009967"
FT PROPEP 190..199
FT /evidence="ECO:0000255"
FT /id="PRO_0000009968"
FT PEPTIDE 200..205
FT /note="LWamide I"
FT /evidence="ECO:0000255"
FT /id="PRO_0000009969"
FT PROPEP 208..212
FT /evidence="ECO:0000255"
FT /id="PRO_0000009970"
FT PEPTIDE 213..217
FT /note="LWamide III"
FT /evidence="ECO:0000255"
FT /id="PRO_0000009971"
FT PROPEP 221..230
FT /evidence="ECO:0000255"
FT /id="PRO_0000009972"
FT PEPTIDE 231..236
FT /note="LWamide I"
FT /evidence="ECO:0000255"
FT /id="PRO_0000009973"
FT PROPEP 239..243
FT /evidence="ECO:0000255"
FT /id="PRO_0000009974"
FT PEPTIDE 244..248
FT /note="LWamide III"
FT /evidence="ECO:0000255"
FT /id="PRO_0000009975"
FT PEPTIDE 252..257
FT /note="LWamide IV"
FT /evidence="ECO:0000255"
FT /id="PRO_0000009976"
FT PROPEP 260..264
FT /evidence="ECO:0000255"
FT /id="PRO_0000009977"
FT PEPTIDE 265..269
FT /note="LWamide V"
FT /evidence="ECO:0000255"
FT /id="PRO_0000009978"
FT PEPTIDE 273..278
FT /note="LWamide I"
FT /evidence="ECO:0000255"
FT /id="PRO_0000009979"
FT PROPEP 281..284
FT /evidence="ECO:0000255"
FT /id="PRO_0000009980"
FT PEPTIDE 285..290
FT /note="Metamorphosin A"
FT /evidence="ECO:0000269|PubMed:7911112"
FT /id="PRO_0000009981"
FT PEPTIDE 294..299
FT /note="LWamide I"
FT /evidence="ECO:0000255"
FT /id="PRO_0000009982"
FT PROPEP 302..305
FT /evidence="ECO:0000255"
FT /id="PRO_0000009983"
FT PEPTIDE 306..311
FT /note="Metamorphosin A"
FT /evidence="ECO:0000269|PubMed:7911112"
FT /id="PRO_0000009984"
FT PEPTIDE 315..320
FT /note="LWamide I"
FT /evidence="ECO:0000255"
FT /id="PRO_0000009985"
FT PROPEP 323..326
FT /evidence="ECO:0000255"
FT /id="PRO_0000009986"
FT PEPTIDE 327..332
FT /note="Metamorphosin A"
FT /evidence="ECO:0000269|PubMed:7911112"
FT /id="PRO_0000009987"
FT PEPTIDE 336..341
FT /note="LWamide I"
FT /evidence="ECO:0000255"
FT /id="PRO_0000009988"
FT PROPEP 344..347
FT /evidence="ECO:0000255"
FT /id="PRO_0000009989"
FT PEPTIDE 348..353
FT /note="Metamorphosin A"
FT /evidence="ECO:0000269|PubMed:7911112"
FT /id="PRO_0000009990"
FT PROPEP 356..366
FT /evidence="ECO:0000255"
FT /id="PRO_0000009991"
FT PEPTIDE 367..372
FT /note="Metamorphosin A"
FT /evidence="ECO:0000269|PubMed:7911112"
FT /id="PRO_0000009992"
FT PROPEP 376..387
FT /evidence="ECO:0000255"
FT /id="PRO_0000009993"
FT PEPTIDE 388..393
FT /note="Metamorphosin A"
FT /evidence="ECO:0000269|PubMed:7911112"
FT /id="PRO_0000009994"
FT PEPTIDE 397..402
FT /note="LWamide I"
FT /evidence="ECO:0000255"
FT /id="PRO_0000009995"
FT PROPEP 405..408
FT /evidence="ECO:0000255"
FT /id="PRO_0000009996"
FT PEPTIDE 409..414
FT /note="Metamorphosin A"
FT /evidence="ECO:0000269|PubMed:7911112"
FT /id="PRO_0000009997"
FT PEPTIDE 418..423
FT /note="LWamide I"
FT /evidence="ECO:0000255"
FT /id="PRO_0000009998"
FT PROPEP 426..429
FT /evidence="ECO:0000255"
FT /id="PRO_0000009999"
FT PEPTIDE 430..435
FT /note="Metamorphosin A"
FT /evidence="ECO:0000269|PubMed:7911112"
FT /id="PRO_0000010000"
FT PEPTIDE 439..444
FT /note="LWamide I"
FT /evidence="ECO:0000255"
FT /id="PRO_0000010001"
FT PROPEP 447..450
FT /evidence="ECO:0000255"
FT /id="PRO_0000010002"
FT PEPTIDE 451..456
FT /note="Metamorphosin A"
FT /evidence="ECO:0000269|PubMed:7911112"
FT /id="PRO_0000010003"
FT PEPTIDE 460..465
FT /note="LWamide I"
FT /evidence="ECO:0000255"
FT /id="PRO_0000010004"
FT PROPEP 468..472
FT /evidence="ECO:0000255"
FT /id="PRO_0000010005"
FT PEPTIDE 473..477
FT /note="LWamide IX"
FT /evidence="ECO:0000255"
FT /id="PRO_0000010006"
FT PEPTIDE 481..487
FT /note="LWamide VIII"
FT /evidence="ECO:0000255"
FT /id="PRO_0000010007"
FT PROPEP 490..514
FT /evidence="ECO:0000255"
FT /id="PRO_0000010008"
FT REGION 23..180
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 258..475
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..514
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..73
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 81
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 90
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 102
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 111
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 123
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 132
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 144
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 153
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 165
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 174
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 186
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 205
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 217
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 236
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 248
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 257
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 269
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 278
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 290
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 299
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 311
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 320
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 332
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 341
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 353
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 372
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 393
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 402
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 414
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 423
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 435
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 444
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 456
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 465
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 477
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
FT MOD_RES 487
FT /note="Tryptophan amide"
FT /evidence="ECO:0000255"
SQ SEQUENCE 514 AA; 56395 MW; EF2F3510089691BD CRC64;
MALKCHLVLL AITLLLAQCS GSVDKKDSTT NHLDEKKTDS TEAHIVQETD ALKENSYLGA
EEESKEEDKK RSAAPQQPGL WGKRQKIGLW GRSADAGQPG LWGKRQSPGL WGRSADAGQP
GLWGKRQNPG LWGRSADAGQ PGLWGKRQNP GLWGRSADAG QPGLWGKRQN PGLWGRSADA
RQPGLWGKRE IYALWGGKRQ NPGLWGRSAD PGQPGLWGKR ELVGLWGGKR QNPGLWGRSA
EAGQPGLWGK RQKIGLWGRS ADPLQPGLWG KRQNPGLWGR SADPQQPGLW GKRQNPGLWG
RSADPQQPGL WGKRQNPGLW GRSADPQQPG LWGKRQNPGL WGRSADPQQP GLWGKSPGLW
GRSADPQQPG LWGKRQNPGF WGRSADPQQP GLWGKRQNPG LWGRSADPQQ PGLWGKRQNP
GLWGRSADPQ QPGLWGKRQN PGLWGRSADP QQPGLWGKRQ NPGLWGRSAG SGQLGLWGKR
QSRIGLWGRS AEPPQFEDLE DLKKKSAIPQ PKGQ
