LWD1_ARATH
ID LWD1_ARATH Reviewed; 346 AA.
AC Q9LPV9; O24513; Q8LAQ5;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 25-MAY-2022, entry version 127.
DE RecName: Full=WD repeat-containing protein LWD1;
DE AltName: Full=Protein ANTHOCYANIN 11-A;
DE Short=AtAN11-A;
DE AltName: Full=Protein LIGHT-REGULATED WD1;
DE AltName: Full=WD repeat-containing protein AN11-A;
GN Name=LWD1; Synonyms=AN11A; OrderedLocusNames=At1g12910; ORFNames=F13K23.16;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=9192870; DOI=10.1101/gad.11.11.1422;
RA de Vetten N., Quattrocchio F., Mol J., Koes R.;
RT "The an11 locus controlling flower pigmentation in petunia encodes a novel
RT WD-repeat protein conserved in yeast, plants, and animals.";
RL Genes Dev. 11:1422-1434(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=18676661; DOI=10.1104/pp.108.124917;
RA Wu J.-F., Wang Y., Wu S.-H.;
RT "Two new clock proteins, LWD1 and LWD2, regulate Arabidopsis photoperiodic
RT flowering.";
RL Plant Physiol. 148:948-959(2008).
RN [7]
RP FUNCTION, INDUCTION, AND SUBCELLULAR LOCATION.
RX PubMed=21357491; DOI=10.1105/tpc.110.081661;
RA Wang Y., Wu J.F., Nakamichi N., Sakakibara H., Nam H.G., Wu S.H.;
RT "LIGHT-REGULATED WD1 and PSEUDO-RESPONSE REGULATOR9 form a positive
RT feedback regulatory loop in the Arabidopsis circadian clock.";
RL Plant Cell 23:486-498(2011).
CC -!- FUNCTION: Clock protein essential for the proper expression phase and
CC period length of both the oscillator and output genes known to
CC participate in photoperiod sensing. Required for the expression of
CC APRR9, APRR7, and APRR5. Regulated by APRR9 and APRR7 at the
CC transcriptional level, indicating the existence of a positive feedback
CC loop within the circadian clock (PubMed:21357491). May function to
CC delay the expression of the morning genes until dawn approaches.
CC {ECO:0000269|PubMed:18676661, ECO:0000269|PubMed:21357491}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:21357491}.
CC -!- DEVELOPMENTAL STAGE: Exhibits circadian rhythm expression.
CC {ECO:0000269|PubMed:18676661}.
CC -!- INDUCTION: Circadian-regulation. {ECO:0000269|PubMed:21357491}.
CC -!- DISRUPTION PHENOTYPE: Plants lacking LWD1 do not show obvious
CC phenotypic alterations. Plants lacking both LWD1 and LWD2 are early
CC flowering and this phenotype is more prominent under short-day
CC conditions. {ECO:0000269|PubMed:18676661}.
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DR EMBL; U94746; AAC18912.1; -; mRNA.
DR EMBL; AC012187; AAF78495.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28948.1; -; Genomic_DNA.
DR EMBL; AY093101; AAM13100.1; -; mRNA.
DR EMBL; AY128776; AAM91176.1; -; mRNA.
DR EMBL; AY087676; AAM65213.1; -; mRNA.
DR PIR; G86262; G86262.
DR RefSeq; NP_172751.1; NM_101162.3.
DR AlphaFoldDB; Q9LPV9; -.
DR SMR; Q9LPV9; -.
DR BioGRID; 23089; 3.
DR STRING; 3702.AT1G12910.1; -.
DR iPTMnet; Q9LPV9; -.
DR PaxDb; Q9LPV9; -.
DR PRIDE; Q9LPV9; -.
DR ProteomicsDB; 238743; -.
DR EnsemblPlants; AT1G12910.1; AT1G12910.1; AT1G12910.
DR GeneID; 837849; -.
DR Gramene; AT1G12910.1; AT1G12910.1; AT1G12910.
DR KEGG; ath:AT1G12910; -.
DR Araport; AT1G12910; -.
DR TAIR; locus:2010356; AT1G12910.
DR eggNOG; KOG0290; Eukaryota.
DR HOGENOM; CLU_013694_0_0_1; -.
DR InParanoid; Q9LPV9; -.
DR OMA; INQIQWG; -.
DR OrthoDB; 750776at2759; -.
DR PhylomeDB; Q9LPV9; -.
DR PRO; PR:Q9LPV9; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9LPV9; baseline and differential.
DR Genevisible; Q9LPV9; AT.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:TAIR.
DR GO; GO:0009718; P:anthocyanin-containing compound biosynthetic process; NAS:TAIR.
DR GO; GO:0043153; P:entrainment of circadian clock by photoperiod; IEP:TAIR.
DR GO; GO:0048573; P:photoperiodism, flowering; IMP:TAIR.
DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR045159; DCAF7-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR19919; PTHR19919; 1.
DR Pfam; PF00400; WD40; 1.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 1.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Biological rhythms; Nucleus; Reference proteome; Repeat;
KW Sensory transduction; WD repeat.
FT CHAIN 1..346
FT /note="WD repeat-containing protein LWD1"
FT /id="PRO_0000363139"
FT REPEAT 79..121
FT /note="WD 1"
FT REPEAT 133..173
FT /note="WD 2"
FT REPEAT 176..214
FT /note="WD 3"
FT REPEAT 265..305
FT /note="WD 4"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9XGN1"
FT CONFLICT 231
FT /note="N -> D (in Ref. 1; AAC18912)"
FT /evidence="ECO:0000305"
FT CONFLICT 295
FT /note="W -> L (in Ref. 5; AAM65213)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 346 AA; 39089 MW; 5F6BE5243854BE93 CRC64;
MGTSSDPIQD GSDEQQKRSE IYTYEAPWHI YAMNWSVRRD KKYRLAITSL LEQYPNRVEI
VQLDESNGEI RSDPNLSFEH PYPPTKTIFI PDKECQRPDL LATSSDFLRL WRIADDHSRV
ELKSCLNSNK NSEFCGPLTS FDWNEAEPRR IGTSSTDTTC TIWDIEREAV DTQLIAHDKE
VFDIAWGGVG VFASVSADGS VRVFDLRDKE HSTIIYESSE PDTPLVRLGW NKQDPRYMAT
IIMDSAKVVV LDIRFPALPV VELQRHQASV NAIAWAPHSS CHICTAGDDS QALIWDISSM
GQHVEGGLDP ILAYTAGAEI EQLQWSSSQP DWVAIAFSTK LQILRV
