LWD2_ARATH
ID LWD2_ARATH Reviewed; 346 AA.
AC Q38960; Q84W53;
DT 10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 25-MAY-2022, entry version 129.
DE RecName: Full=WD repeat-containing protein LWD2;
DE AltName: Full=Protein ANTHOCYANIN 11-B;
DE Short=AtAN11-B;
DE AltName: Full=Protein LIGHT-REGULATED WD2;
DE AltName: Full=WD repeat-containing protein AN11-B;
GN Name=LWD2; Synonyms=AN11B; OrderedLocusNames=At3g26640;
GN ORFNames=MLJ15.3, orf10;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=8932388; DOI=10.1093/nar/24.21.4313;
RA Quigley F., Dao P., Cottet A., Mache R.;
RT "Sequence analysis of an 81 kb contig from Arabidopsis thaliana chromosome
RT III.";
RL Nucleic Acids Res. 24:4313-4318(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP IDENTIFICATION.
RC STRAIN=cv. Columbia;
RX PubMed=9192870; DOI=10.1101/gad.11.11.1422;
RA de Vetten N., Quattrocchio F., Mol J., Koes R.;
RT "The an11 locus controlling flower pigmentation in petunia encodes a novel
RT WD-repeat protein conserved in yeast, plants, and animals.";
RL Genes Dev. 11:1422-1434(1997).
RN [8]
RP INDUCTION BY VIRUS INFECTION.
RX PubMed=12535341; DOI=10.1046/j.1365-313x.2003.01625.x;
RA Whitham S.A., Quan S., Chang H.S., Cooper B., Estes B., Zhu T., Wang X.,
RA Hou Y.M.;
RT "Diverse RNA viruses elicit the expression of common sets of genes in
RT susceptible Arabidopsis thaliana plants.";
RL Plant J. 33:271-283(2003).
RN [9]
RP FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=18676661; DOI=10.1104/pp.108.124917;
RA Wu J.-F., Wang Y., Wu S.-H.;
RT "Two new clock proteins, LWD1 and LWD2, regulate Arabidopsis photoperiodic
RT flowering.";
RL Plant Physiol. 148:948-959(2008).
RN [10]
RP FUNCTION, AND INDUCTION.
RX PubMed=21357491; DOI=10.1105/tpc.110.081661;
RA Wang Y., Wu J.F., Nakamichi N., Sakakibara H., Nam H.G., Wu S.H.;
RT "LIGHT-REGULATED WD1 and PSEUDO-RESPONSE REGULATOR9 form a positive
RT feedback regulatory loop in the Arabidopsis circadian clock.";
RL Plant Cell 23:486-498(2011).
CC -!- FUNCTION: Clock protein essential for the proper expression phase and
CC period length of both the oscillator and output genes known to
CC participate in photoperiod sensing. Required for the expression of
CC APRR9, APRR7, and APRR5. Regulated by APRR9 and APRR7 at the
CC transcriptional level, indicating the existence of a positive feedback
CC loop within the circadian clock (PubMed:21357491).
CC {ECO:0000269|PubMed:18676661, ECO:0000269|PubMed:21357491}.
CC -!- DEVELOPMENTAL STAGE: Constant expression level.
CC {ECO:0000269|PubMed:18676661}.
CC -!- INDUCTION: Circadian-regulation. Up-regulated y virus infection.
CC {ECO:0000269|PubMed:12535341, ECO:0000269|PubMed:21357491}.
CC -!- DISRUPTION PHENOTYPE: Plants lacking LWD2 do not show obvious
CC phenotypic alterations. Plants lacking both LWD1 and LWD2 are early
CC flowering and this phenotype is more prominent under short-day
CC conditions. {ECO:0000269|PubMed:18676661}.
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DR EMBL; X97488; CAA66120.1; -; mRNA.
DR EMBL; X98130; CAA66815.1; -; Genomic_DNA.
DR EMBL; AB026648; BAB01729.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE77190.1; -; Genomic_DNA.
DR EMBL; BT004214; AAO42231.1; -; mRNA.
DR EMBL; AY086141; AAM63346.1; -; mRNA.
DR EMBL; BT020361; AAV85716.1; -; mRNA.
DR RefSeq; NP_189298.1; NM_113575.4.
DR AlphaFoldDB; Q38960; -.
DR SMR; Q38960; -.
DR STRING; 3702.AT3G26640.1; -.
DR PaxDb; Q38960; -.
DR PRIDE; Q38960; -.
DR ProteomicsDB; 238744; -.
DR EnsemblPlants; AT3G26640.1; AT3G26640.1; AT3G26640.
DR GeneID; 822276; -.
DR Gramene; AT3G26640.1; AT3G26640.1; AT3G26640.
DR KEGG; ath:AT3G26640; -.
DR Araport; AT3G26640; -.
DR TAIR; locus:2090792; AT3G26640.
DR eggNOG; KOG0290; Eukaryota.
DR HOGENOM; CLU_013694_0_0_1; -.
DR InParanoid; Q38960; -.
DR OMA; NWSIRRD; -.
DR OrthoDB; 750776at2759; -.
DR PhylomeDB; Q38960; -.
DR PRO; PR:Q38960; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q38960; baseline and differential.
DR Genevisible; Q38960; AT.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0043153; P:entrainment of circadian clock by photoperiod; IEP:TAIR.
DR GO; GO:0048573; P:photoperiodism, flowering; IMP:TAIR.
DR GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
DR Gene3D; 2.130.10.10; -; 1.
DR InterPro; IPR045159; DCAF7-like.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR PANTHER; PTHR19919; PTHR19919; 1.
DR Pfam; PF00400; WD40; 2.
DR SMART; SM00320; WD40; 3.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 2.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Biological rhythms; Reference proteome; Repeat;
KW Sensory transduction; WD repeat.
FT CHAIN 1..346
FT /note="WD repeat-containing protein LWD2"
FT /id="PRO_0000363140"
FT REPEAT 79..121
FT /note="WD 1"
FT REPEAT 133..173
FT /note="WD 2"
FT REPEAT 176..214
FT /note="WD 3"
FT REPEAT 265..305
FT /note="WD 4"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q9XGN1"
FT CONFLICT 70
FT /note="I -> V (in Ref. 4; AAO42231)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 346 AA; 39092 MW; C71DB62672451214 CRC64;
MVTSSDQIQN GSEEQSKRSE IYTYEAPWQI YAMNWSIRRD KKYRLAITSL IEQYPNRVEI
VQLDESNGEI RSDPNLCFEH PYPPTKTSFI PDKECQRPDL LATSSDFLRL WRISDDESRV
ELKSCLSSDK NSEFSGPITS FDWNEAEPRR IGTSSIDTTC TIWDIEREVV DTQLIAHDKE
VYDIAWGGVG VFASVSEDGS VRVFDLRDKE HSTIIYESGE PSTPLVRLSW NKQDPRYMAT
VIMGSAKIVV LDIRFPALPV VELQRHQASV NAIAWAPHSS SHICSAGDDS QALIWDISSM
GQHVEGGLDP ILAYTAGAEV EQLQWSSSQP DWVAIAFSNK LQILRV
