5MP2A_DANRE
ID 5MP2A_DANRE Reviewed; 419 AA.
AC Q6PD83;
DT 31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=eIF5-mimic protein 2-A {ECO:0000250|UniProtKB:Q7L1Q6};
DE AltName: Full=Basic leucine zipper and W2 domain-containing protein 1-A;
GN Name=bzw1a; Synonyms=5mp2a {ECO:0000250|UniProtKB:Q7L1Q6}, bzw1;
GN ORFNames=si:ch211-246m6.3, zgc:63787;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=AB;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Translation initiation regulator which may repress repeat-
CC associated non-AUG (RAN) initiated translation probably by acting as a
CC competitive inhibitor of eukaryotic translation initiation factor 5
CC (EIF5) function (By similarity). Enhances histone H4 gene transcription
CC but does not seem to bind DNA directly (By similarity).
CC {ECO:0000250|UniProtKB:Q7L1Q6}.
CC -!- SIMILARITY: Belongs to the BZW family. {ECO:0000305}.
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DR EMBL; BX649296; CAK04748.1; -; Genomic_DNA.
DR EMBL; BC058875; AAH58875.1; -; mRNA.
DR RefSeq; NP_956002.1; NM_199708.1.
DR AlphaFoldDB; Q6PD83; -.
DR STRING; 7955.ENSDARP00000022789; -.
DR PaxDb; Q6PD83; -.
DR PRIDE; Q6PD83; -.
DR Ensembl; ENSDART00000013575; ENSDARP00000022789; ENSDARG00000010481.
DR GeneID; 325226; -.
DR KEGG; dre:325226; -.
DR CTD; 325226; -.
DR ZFIN; ZDB-GENE-030131-3951; bzw1a.
DR eggNOG; KOG2297; Eukaryota.
DR GeneTree; ENSGT00390000012561; -.
DR HOGENOM; CLU_032849_0_1_1; -.
DR InParanoid; Q6PD83; -.
DR OMA; KDAHMAK; -.
DR OrthoDB; 653740at2759; -.
DR PhylomeDB; Q6PD83; -.
DR TreeFam; TF324313; -.
DR PRO; PR:Q6PD83; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 22.
DR Bgee; ENSDARG00000010481; Expressed in early embryo and 31 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0006446; P:regulation of translational initiation; ISS:UniProtKB.
DR CDD; cd11560; W2_eIF5C_like; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR043510; W2_BZW1/2.
DR InterPro; IPR003307; W2_domain.
DR Pfam; PF02020; W2; 1.
DR SMART; SM00515; eIF5C; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS51363; W2; 1.
PE 2: Evidence at transcript level;
KW Activator; Reference proteome; Transcription; Transcription regulation;
KW Translation regulation.
FT CHAIN 1..419
FT /note="eIF5-mimic protein 2-A"
FT /id="PRO_0000254614"
FT DOMAIN 247..414
FT /note="W2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00695"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..29
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 419 AA; 48076 MW; AA8F3B3A2AA1C4AB CRC64;
MNNQKQQKPT LTGQRFKTRK RDEKERFDPS QFQESIVQGL NQTGTDLEAV AKFLDASGAK
LDYRRYAETL FDILVAGGML APGGTLSDDL TRTEYCLFTA SEDLETMQAY AQVFNKLIRR
YKYLEKGFEE EIKKLLLFLK GFTESERNKL AMLTGILLAN GNISASILNS LFNENLVKEG
VSAAFAVKLF KSWINEKDIN SVAASLRKVG MDNRLMELFP ANKRSCEHFS KYFTDAGLKE
LSDFARNQQS IGARKELQKE LQEQMSRGET LKDIIAYVRE EMKKTSISEQ TMIGIVWTSV
MSSVEWNKKE ELVTEQAIKH LKQYSPLLKA FTSQGLSELT LLLKIQEYCY DNIHFMKAFQ
KIVVLLYKAD VLSEEVILKW YTEGHVAKGK SVFLEQMKKF VEWLKNAEEE SESEEEEGD
