LY65B_HUMAN
ID LY65B_HUMAN Reviewed; 201 AA.
AC Q8NDX9; B0UXB2; B0UZ65; B0UZP8; B7ZCA3; Q5SQ62; Q5SST3; Q9UKT0; Q9UMQ0;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Lymphocyte antigen 6 complex locus protein G5b;
DE Flags: Precursor;
GN Name=LY6G5B; Synonyms=C6orf19, G5B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RX PubMed=8812450; DOI=10.1006/geno.1996.0459;
RA Albertella M.R., Jones H., Thomson W., Olavesen M.G., Campbell R.D.;
RT "Localization of eight additional genes in the human major
RT histocompatibility complex, including the gene encoding the casein kinase
RT II beta subunit (CSNK2B).";
RL Genomics 36:240-251(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=12079290; DOI=10.1006/geno.2002.6794;
RA Mallya M., Campbell R.D., Aguado B.;
RT "Transcriptional analysis of a novel cluster of LY-6 family members in the
RT human and mouse major histocompatibility complex: five genes with many
RT splice forms.";
RL Genomics 80:113-123(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Shiina S., Tamiya G., Oka A., Inoko H.;
RT "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region.";
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14656967; DOI=10.1101/gr.1736803;
RA Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D.,
RA Hood L.;
RT "Analysis of the gene-dense major histocompatibility complex class III
RT region and its comparison to mouse.";
RL Genome Res. 13:2621-2636(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT CYS-176.
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP GLYCOSYLATION, AND SUBUNIT.
RX PubMed=17008713; DOI=10.1110/ps.062242606;
RA Mallya M., Campbell R.D., Aguado B.;
RT "Characterization of the five novel Ly-6 superfamily members encoded in the
RT MHC, and detection of cells expressing their potential ligands.";
RL Protein Sci. 15:2244-2256(2006).
CC -!- SUBUNIT: Forms oligomer. {ECO:0000269|PubMed:17008713}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8NDX9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NDX9-2; Sequence=VSP_031255;
CC -!- PTM: N-glycosylated. {ECO:0000269|PubMed:17008713}.
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DR EMBL; AJ245417; CAB52191.1; -; mRNA.
DR EMBL; AJ315545; CAC85543.1; -; mRNA.
DR EMBL; AK289364; BAF82053.1; -; mRNA.
DR EMBL; BA000025; BAB63385.1; -; Genomic_DNA.
DR EMBL; AF129756; AAF04397.1; -; Genomic_DNA.
DR EMBL; AL662899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL670886; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL805934; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX511262; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR354443; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR753842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471081; EAX03476.1; -; Genomic_DNA.
DR CCDS; CCDS34400.1; -. [Q8NDX9-1]
DR RefSeq; NP_067044.2; NM_021221.2. [Q8NDX9-1]
DR AlphaFoldDB; Q8NDX9; -.
DR BioGRID; 121826; 283.
DR STRING; 9606.ENSP00000365024; -.
DR GlyGen; Q8NDX9; 2 sites.
DR iPTMnet; Q8NDX9; -.
DR PhosphoSitePlus; Q8NDX9; -.
DR BioMuta; LY6G5B; -.
DR DMDM; 74751234; -.
DR MassIVE; Q8NDX9; -.
DR PaxDb; Q8NDX9; -.
DR PeptideAtlas; Q8NDX9; -.
DR PRIDE; Q8NDX9; -.
DR ProteomicsDB; 73088; -. [Q8NDX9-2]
DR Antibodypedia; 34937; 39 antibodies from 15 providers.
DR DNASU; 58496; -.
DR Ensembl; ENST00000375864.4; ENSP00000365024.4; ENSG00000240053.8. [Q8NDX9-1]
DR Ensembl; ENST00000409525.1; ENSP00000386365.1; ENSG00000240053.8. [Q8NDX9-2]
DR Ensembl; ENST00000462244.1; ENSP00000418445.1; ENSG00000239285.7.
DR Ensembl; ENST00000471674.1; ENSP00000417055.1; ENSG00000241132.7. [Q8NDX9-1]
DR Ensembl; ENST00000480515.1; ENSP00000418119.1; ENSG00000240433.4. [Q8NDX9-1]
DR Ensembl; ENST00000480530.1; ENSP00000417822.1; ENSG00000241713.7. [Q8NDX9-1]
DR Ensembl; ENST00000484964.1; ENSP00000420698.1; ENSG00000244672.4. [Q8NDX9-1]
DR Ensembl; ENST00000490011.1; ENSP00000418217.1; ENSG00000239497.7.
DR GeneID; 58496; -.
DR KEGG; hsa:58496; -.
DR MANE-Select; ENST00000375864.5; ENSP00000365024.4; NM_021221.3; NP_067044.2.
DR UCSC; uc003nvt.2; human. [Q8NDX9-1]
DR CTD; 58496; -.
DR DisGeNET; 58496; -.
DR GeneCards; LY6G5B; -.
DR HGNC; HGNC:13931; LY6G5B.
DR HPA; ENSG00000240053; Low tissue specificity.
DR MIM; 610433; gene.
DR neXtProt; NX_Q8NDX9; -.
DR OpenTargets; ENSG00000240053; -.
DR PharmGKB; PA37826; -.
DR VEuPathDB; HostDB:ENSG00000240053; -.
DR eggNOG; ENOG502SXN1; Eukaryota.
DR GeneTree; ENSGT00520000060793; -.
DR HOGENOM; CLU_120540_0_0_1; -.
DR InParanoid; Q8NDX9; -.
DR OMA; CMVISIY; -.
DR PhylomeDB; Q8NDX9; -.
DR TreeFam; TF338717; -.
DR PathwayCommons; Q8NDX9; -.
DR BioGRID-ORCS; 58496; 7 hits in 1064 CRISPR screens.
DR ChiTaRS; LY6G5B; human.
DR GenomeRNAi; 58496; -.
DR Pharos; Q8NDX9; Tdark.
DR PRO; PR:Q8NDX9; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q8NDX9; protein.
DR Bgee; ENSG00000240053; Expressed in right hemisphere of cerebellum and 93 other tissues.
DR ExpressionAtlas; Q8NDX9; baseline and differential.
DR Genevisible; Q8NDX9; HS.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0032991; C:protein-containing complex; IDA:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; IDA:UniProtKB.
DR InterPro; IPR038773; LY6G5B.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR PANTHER; PTHR14313; PTHR14313; 1.
DR SUPFAM; SSF57302; SSF57302; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..201
FT /note="Lymphocyte antigen 6 complex locus protein G5b"
FT /id="PRO_0000318602"
FT DOMAIN 26..118
FT /note="UPAR/Ly6"
FT CARBOHYD 141
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 183
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 28..55
FT /evidence="ECO:0000250"
FT DISULFID 31..40
FT /evidence="ECO:0000250"
FT DISULFID 47..73
FT /evidence="ECO:0000250"
FT DISULFID 81..98
FT /evidence="ECO:0000250"
FT DISULFID 99..104
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..55
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:8812450"
FT /id="VSP_031255"
FT VARIANT 102
FT /note="D -> N (in dbSNP:rs805267)"
FT /id="VAR_038842"
FT VARIANT 131
FT /note="S -> Y (in dbSNP:rs11758242)"
FT /id="VAR_038843"
FT VARIANT 176
FT /note="R -> C (in dbSNP:rs9267532)"
FT /evidence="ECO:0000269|PubMed:14574404"
FT /id="VAR_038844"
SQ SEQUENCE 201 AA; 22572 MW; E2CDFCDD5E166056 CRC64;
MKVHMLVGVL VMVGFTVGKV PVPDIRTCHF CLVEDPSVGC ISGSEKCTIS SSSLCMVITI
YYDVKVRFIV RGCGQYISYR CQEKRNTYFA EYWYQAQCCQ YDYCNSWSSP QLQSSLPEPH
DRPLALPLSD SQIQWFYQAL NLSLPLPNFH AGTEPDGLDP MVTLSLNLGL SFAELRRMYL
FLNSSGLLVL PQAGLLTPHP S
