LY65B_MOUSE
ID LY65B_MOUSE Reviewed; 194 AA.
AC Q8K1T4; Q3U982;
DT 26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Lymphocyte antigen 6 complex locus protein G5b;
DE Flags: Precursor;
GN Name=Ly6g5b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC STRAIN=129;
RX PubMed=12079290; DOI=10.1006/geno.2002.6794;
RA Mallya M., Campbell R.D., Aguado B.;
RT "Transcriptional analysis of a novel cluster of LY-6 family members in the
RT human and mouse major histocompatibility complex: five genes with many
RT splice forms.";
RL Genomics 80:113-123(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Bone marrow;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP GLYCOSYLATION, AND SUBUNIT.
RX PubMed=17008713; DOI=10.1110/ps.062242606;
RA Mallya M., Campbell R.D., Aguado B.;
RT "Characterization of the five novel Ly-6 superfamily members encoded in the
RT MHC, and detection of cells expressing their potential ligands.";
RL Protein Sci. 15:2244-2256(2006).
CC -!- SUBUNIT: Monomer. {ECO:0000269|PubMed:17008713}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8K1T4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8K1T4-2; Sequence=VSP_031256;
CC -!- PTM: N-glycosylated. {ECO:0000269|PubMed:17008713}.
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DR EMBL; AJ315553; CAC85549.1; -; mRNA.
DR EMBL; AK151902; BAE30785.1; -; mRNA.
DR EMBL; BC131964; AAI31965.1; -; mRNA.
DR EMBL; BC131966; AAI31967.1; -; mRNA.
DR CCDS; CCDS28683.1; -. [Q8K1T4-1]
DR CCDS; CCDS89083.1; -. [Q8K1T4-2]
DR RefSeq; NP_683741.1; NM_148939.2. [Q8K1T4-1]
DR AlphaFoldDB; Q8K1T4; -.
DR BioGRID; 234462; 3.
DR STRING; 10090.ENSMUSP00000052133; -.
DR GlyGen; Q8K1T4; 2 sites.
DR PhosphoSitePlus; Q8K1T4; -.
DR EPD; Q8K1T4; -.
DR PaxDb; Q8K1T4; -.
DR PRIDE; Q8K1T4; -.
DR ProteomicsDB; 290193; -. [Q8K1T4-1]
DR ProteomicsDB; 290194; -. [Q8K1T4-2]
DR DNASU; 266614; -.
DR Ensembl; ENSMUST00000062657; ENSMUSP00000052133; ENSMUSG00000043807. [Q8K1T4-1]
DR Ensembl; ENSMUST00000172854; ENSMUSP00000138033; ENSMUSG00000043807. [Q8K1T4-2]
DR GeneID; 266614; -.
DR KEGG; mmu:266614; -.
DR UCSC; uc008cfs.2; mouse. [Q8K1T4-1]
DR CTD; 58496; -.
DR MGI; MGI:2385809; Ly6g5b.
DR VEuPathDB; HostDB:ENSMUSG00000043807; -.
DR eggNOG; ENOG502SXN1; Eukaryota.
DR GeneTree; ENSGT00520000060793; -.
DR HOGENOM; CLU_120540_0_0_1; -.
DR InParanoid; Q8K1T4; -.
DR OMA; CMVISIY; -.
DR PhylomeDB; Q8K1T4; -.
DR TreeFam; TF338717; -.
DR BioGRID-ORCS; 266614; 0 hits in 72 CRISPR screens.
DR PRO; PR:Q8K1T4; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q8K1T4; protein.
DR Bgee; ENSMUSG00000043807; Expressed in granulocyte and 55 other tissues.
DR ExpressionAtlas; Q8K1T4; baseline and differential.
DR GO; GO:0009897; C:external side of plasma membrane; ISO:MGI.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0032991; C:protein-containing complex; ISO:MGI.
DR InterPro; IPR038773; LY6G5B.
DR PANTHER; PTHR14313; PTHR14313; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..194
FT /note="Lymphocyte antigen 6 complex locus protein G5b"
FT /id="PRO_0000318603"
FT DOMAIN 26..118
FT /note="UPAR/Ly6"
FT CARBOHYD 63
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 141
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 28..55
FT /evidence="ECO:0000250"
FT DISULFID 31..40
FT /evidence="ECO:0000250"
FT DISULFID 47..73
FT /evidence="ECO:0000250"
FT DISULFID 81..98
FT /evidence="ECO:0000250"
FT DISULFID 99..104
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..55
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_031256"
SQ SEQUENCE 194 AA; 21615 MW; 8933A9014909AFDF CRC64;
MRARVLVGML TMVGFAMGKA PVARVRTCHL CLLEDPSLGC ISGSEKCTIS LPSPCMVITI
YKNTTVRFHV RGCGQHHSYR CQERHVIYQS DYLYKADCCQ YDYCNSWSSA QHQSTLRGSP
GSHLGMPLSA SQIKQFYQAL NLSLPQPGFH AHKVSEGLES LILPPELGLS IADLRQIYLF
LNSSGLLVLP WDRP
