LY65C_HUMAN
ID LY65C_HUMAN Reviewed; 150 AA.
AC Q5SRR4; A6NCW4; B0UXB3; B0UXB4; B0UZ69; B0UZQ0; B1B0L9; O95871; Q5SQ59;
AC Q8NDY0; Q8NDY1;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 20-FEB-2007, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Lymphocyte antigen 6 complex locus protein G5c;
DE Flags: Precursor;
GN Name=LY6G5C; Synonyms=C6orf20, G5C, NG33;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [MRNA] OF 6-229
RP (ISOFORM 3), AND TISSUE SPECIFICITY.
RX PubMed=12079290; DOI=10.1006/geno.2002.6794;
RA Mallya M., Campbell R.D., Aguado B.;
RT "Transcriptional analysis of a novel cluster of LY-6 family members in the
RT human and mouse major histocompatibility complex: five genes with many
RT splice forms.";
RL Genomics 80:113-123(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 2).
RX PubMed=14656967; DOI=10.1101/gr.1736803;
RA Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D.,
RA Hood L.;
RT "Analysis of the gene-dense major histocompatibility complex class III
RT region and its comparison to mouse.";
RL Genome Res. 13:2621-2636(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ISOFORM 2).
RA Shiina S., Tamiya G., Oka A., Inoko H.;
RT "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region.";
RL Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GLYCOSYLATION, AND SUBUNIT.
RX PubMed=17008713; DOI=10.1110/ps.062242606;
RA Mallya M., Campbell R.D., Aguado B.;
RT "Characterization of the five novel Ly-6 superfamily members encoded in the
RT MHC, and detection of cells expressing their potential ligands.";
RL Protein Sci. 15:2244-2256(2006).
CC -!- FUNCTION: May have a role in hematopoietic cell differentiation.
CC -!- SUBUNIT: Forms oligomers. {ECO:0000269|PubMed:17008713}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q5SRR4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5SRR4-2; Sequence=VSP_032004;
CC Name=3;
CC IsoId=Q5SRR4-3; Sequence=VSP_042107;
CC -!- TISSUE SPECIFICITY: Detected in T-cell lines and fetal and adult lung.
CC {ECO:0000269|PubMed:12079290}.
CC -!- PTM: N-glycosylated. {ECO:0000269|PubMed:17008713}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-4 is the initiator.
CC {ECO:0000305}.
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DR EMBL; AJ315541; CAC85522.1; -; mRNA.
DR EMBL; AJ315542; CAC85542.1; -; mRNA.
DR EMBL; AF129756; AAD18080.1; -; Genomic_DNA.
DR EMBL; BA000025; BAB63384.1; -; Genomic_DNA.
DR EMBL; AL662899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL670886; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL805934; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BX511262; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR354443; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR753842; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759761; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471081; EAX03478.1; -; Genomic_DNA.
DR CCDS; CCDS34401.2; -. [Q5SRR4-1]
DR RefSeq; NP_079538.3; NM_025262.3. [Q5SRR4-1]
DR AlphaFoldDB; Q5SRR4; -.
DR BioGRID; 123285; 295.
DR STRING; 9606.ENSP00000372724; -.
DR GlyGen; Q5SRR4; 1 site.
DR BioMuta; LY6G5C; -.
DR DMDM; 172045918; -.
DR PaxDb; Q5SRR4; -.
DR PRIDE; Q5SRR4; -.
DR Antibodypedia; 50054; 29 antibodies from 13 providers.
DR DNASU; 80741; -.
DR Ensembl; ENST00000324540.9; ENSP00000313380.5; ENSG00000111971.14. [Q5SRR4-1]
DR Ensembl; ENST00000383237.4; ENSP00000372724.4; ENSG00000204428.12. [Q5SRR4-1]
DR Ensembl; ENST00000383425.8; ENSP00000372917.4; ENSG00000206404.11. [Q5SRR4-1]
DR Ensembl; ENST00000418117.6; ENSP00000391301.2; ENSG00000228883.9. [Q5SRR4-1]
DR Ensembl; ENST00000431114.6; ENSP00000391878.2; ENSG00000231325.9. [Q5SRR4-1]
DR Ensembl; ENST00000455753.6; ENSP00000413765.2; ENSG00000226404.9. [Q5SRR4-1]
DR Ensembl; ENST00000458081.6; ENSP00000414953.2; ENSG00000237495.9. [Q5SRR4-1]
DR GeneID; 80741; -.
DR KEGG; hsa:80741; -.
DR MANE-Select; ENST00000383237.5; ENSP00000372724.4; NM_025262.4; NP_079538.3.
DR UCSC; uc003nvu.3; human. [Q5SRR4-1]
DR CTD; 80741; -.
DR DisGeNET; 80741; -.
DR GeneCards; LY6G5C; -.
DR HGNC; HGNC:13932; LY6G5C.
DR HPA; ENSG00000204428; Tissue enhanced (testis).
DR MIM; 610434; gene.
DR neXtProt; NX_Q5SRR4; -.
DR OpenTargets; ENSG00000204428; -.
DR PharmGKB; PA37827; -.
DR VEuPathDB; HostDB:ENSG00000204428; -.
DR eggNOG; ENOG502TD7Y; Eukaryota.
DR GeneTree; ENSGT00390000011513; -.
DR HOGENOM; CLU_148118_0_0_1; -.
DR InParanoid; Q5SRR4; -.
DR OMA; QHRGHYI; -.
DR PhylomeDB; Q5SRR4; -.
DR TreeFam; TF338717; -.
DR PathwayCommons; Q5SRR4; -.
DR BioGRID-ORCS; 80741; 6 hits in 1061 CRISPR screens.
DR ChiTaRS; LY6G5C; human.
DR GenomeRNAi; 80741; -.
DR Pharos; Q5SRR4; Tdark.
DR PRO; PR:Q5SRR4; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q5SRR4; protein.
DR Bgee; ENSG00000204428; Expressed in right hemisphere of cerebellum and 97 other tissues.
DR ExpressionAtlas; Q5SRR4; baseline and differential.
DR Genevisible; Q5SRR4; HS.
DR GO; GO:0009897; C:external side of plasma membrane; IEA:Ensembl.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0032991; C:protein-containing complex; IDA:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; IDA:UniProtKB.
DR InterPro; IPR026110; LY6G5C.
DR PANTHER; PTHR14909; PTHR14909; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Disulfide bond; Glycoprotein; Reference proteome;
KW Secreted; Signal.
FT SIGNAL 1..41
FT /evidence="ECO:0000255"
FT CHAIN 42..150
FT /note="Lymphocyte antigen 6 complex locus protein G5c"
FT /id="PRO_0000323016"
FT DOMAIN 60..150
FT /note="UPAR/Ly6"
FT CARBOHYD 96
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 62..89
FT /evidence="ECO:0000250"
FT DISULFID 65..74
FT /evidence="ECO:0000250"
FT DISULFID 81..107
FT /evidence="ECO:0000250"
FT DISULFID 134..139
FT /evidence="ECO:0000250"
FT VAR_SEQ 1..40
FT /note="MRFMAGPAGSQSLGPLCFHSSPQALYTVLLIVLVMMSLVF -> MISRDADL
FT PSCWGAGPCYTGHKVGALRRDTVICCCRHGDYSTPCLFTPGKPSRNPSPWKRTLWTLSA
FT PWAGPAGWTGEEQNATKTGLITRRPRPLRRRPHPAPASPLPEIIRGNIPRML (in
FT isoform 3)"
FT /evidence="ECO:0000303|PubMed:12079290"
FT /id="VSP_042107"
FT VAR_SEQ 1..21
FT /note="MRFMAGPAGSQSLGPLCFHSS -> MQTFPVAGALDPAILDTSS (in
FT isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_032004"
SQ SEQUENCE 150 AA; 16650 MW; 986130D4D1A9B59C CRC64;
MRFMAGPAGS QSLGPLCFHS SPQALYTVLL IVLVMMSLVF GKFVPVNWEP PQPLPFPKYL
RCYRCLLETK ELGCLLGSDI CLTPAGSSCI TLHKKNSSGS DVMVSDCRSK EQMSDCSNTR
TSPVSGFWIF SQYCFLDFCN DPQNRGLYTP
