ID   LY65C_MOUSE             Reviewed;         149 AA.
AC   Q8K1T5; Q0D2G4;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   03-AUG-2022, entry version 101.
DE   RecName: Full=Lymphocyte antigen 6 complex locus protein G5c;
DE   Flags: Precursor;
GN   Name=Ly6g5c;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=129;
RX   PubMed=12079290; DOI=10.1006/geno.2002.6794;
RA   Mallya M., Campbell R.D., Aguado B.;
RT   "Transcriptional analysis of a novel cluster of LY-6 family members in the
RT   human and mouse major histocompatibility complex: five genes with many
RT   splice forms.";
RL   Genomics 80:113-123(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   GLYCOSYLATION, AND SUBUNIT.
RX   PubMed=17008713; DOI=10.1110/ps.062242606;
RA   Mallya M., Campbell R.D., Aguado B.;
RT   "Characterization of the five novel Ly-6 superfamily members encoded in the
RT   MHC, and detection of cells expressing their potential ligands.";
RL   Protein Sci. 15:2244-2256(2006).
CC   -!- FUNCTION: May have a role in hematopoietic cell differentiation.
CC   -!- SUBUNIT: Forms oligomers. {ECO:0000269|PubMed:17008713}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Detected in adult brain.
CC       {ECO:0000269|PubMed:12079290}.
CC   -!- PTM: N-glycosylated. {ECO:0000269|PubMed:17008713}.
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DR   EMBL; AJ315552; CAC85548.1; -; mRNA.
DR   EMBL; BC111447; AAI11448.1; -; mRNA.
DR   EMBL; BC145966; AAI45967.1; -; mRNA.
DR   EMBL; BC145968; AAI45969.1; -; mRNA.
DR   CCDS; CCDS28682.1; -.
DR   RefSeq; NP_683749.1; NM_148947.1.
DR   AlphaFoldDB; Q8K1T5; -.
DR   STRING; 10090.ENSMUSP00000039151; -.
DR   GlyGen; Q8K1T5; 1 site.
DR   PaxDb; Q8K1T5; -.
DR   PRIDE; Q8K1T5; -.
DR   ProteomicsDB; 291970; -.
DR   Antibodypedia; 50054; 29 antibodies from 13 providers.
DR   DNASU; 114652; -.
DR   Ensembl; ENSMUST00000037849; ENSMUSP00000039151; ENSMUSG00000034482.
DR   GeneID; 114652; -.
DR   KEGG; mmu:114652; -.
DR   UCSC; uc008cfr.1; mouse.
DR   CTD; 80741; -.
DR   MGI; MGI:2148974; Ly6g5c.
DR   VEuPathDB; HostDB:ENSMUSG00000034482; -.
DR   eggNOG; ENOG502TD7Y; Eukaryota.
DR   GeneTree; ENSGT00390000011513; -.
DR   HOGENOM; CLU_148118_0_0_1; -.
DR   InParanoid; Q8K1T5; -.
DR   OMA; QHRGHYI; -.
DR   OrthoDB; 1440854at2759; -.
DR   PhylomeDB; Q8K1T5; -.
DR   TreeFam; TF338717; -.
DR   BioGRID-ORCS; 114652; 4 hits in 73 CRISPR screens.
DR   ChiTaRS; Ly6g5c; mouse.
DR   PRO; PR:Q8K1T5; -.
DR   Proteomes; UP000000589; Chromosome 17.
DR   RNAct; Q8K1T5; protein.
DR   Bgee; ENSMUSG00000034482; Expressed in lung and 4 other tissues.
DR   GO; GO:0009897; C:external side of plasma membrane; ISO:MGI.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0032991; C:protein-containing complex; IDA:UniProtKB.
DR   GO; GO:0042802; F:identical protein binding; IDA:UniProtKB.
DR   InterPro; IPR026110; LY6G5C.
DR   PANTHER; PTHR14909; PTHR14909; 1.
PE   1: Evidence at protein level;
KW   Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..41
FT                   /evidence="ECO:0000255"
FT   CHAIN           42..149
FT                   /note="Lymphocyte antigen 6 complex locus protein G5c"
FT                   /id="PRO_0000323018"
FT   DOMAIN          59..149
FT                   /note="UPAR/Ly6"
FT   CARBOHYD        95
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        61..88
FT                   /evidence="ECO:0000250"
FT   DISULFID        64..73
FT                   /evidence="ECO:0000250"
FT   DISULFID        80..106
FT                   /evidence="ECO:0000250"
FT   DISULFID        115..132
FT                   /evidence="ECO:0000250"
FT   DISULFID        133..138
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   149 AA;  16590 MW;  58AF992A36F1A6B6 CRC64;
     MLFMAGPAAS WSLRPLGLHG VPQALCAVLL TVLVMKTLVL GDTKLEDLHP QSLPLNKYLN
     CYRCLLETEE LGCLLGSDTC LTPLGSSCVT LHIKNSSGFN VMVSDCYSKE QMVHCSYTRA
     SPVFGFWIFY QCCFLDFCNN PDNRKNSMH