ID   LY65C_RAT               Reviewed;         145 AA.
AC   Q8CHN2; Q6MG54;
DT   18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Lymphocyte antigen 6 complex locus protein G5c;
DE   AltName: Full=Epididymal secretory protein 8;
DE            Short=Protein RE8;
DE   Flags: Precursor;
GN   Name=Ly6g5c; Synonyms=Re8;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   STRAIN=Sprague-Dawley;
RX   PubMed=14695977;
RA   Kaepler-Hanno K., Kirchhoff C.;
RT   "Rodent epididymal cDNAs identified by sequence homology to human and
RT   canine counterparts.";
RL   Asian J. Androl. 5:277-286(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15060004; DOI=10.1101/gr.1987704;
RA   Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H.,
RA   Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.;
RT   "The genomic sequence and comparative analysis of the rat major
RT   histocompatibility complex.";
RL   Genome Res. 14:631-639(2004).
CC   -!- FUNCTION: May have a role in hematopoietic cell differentiation.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Forms oligomers. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expression restricted to the caput of epididymis.
CC       Detected only from day 24 postnatum. {ECO:0000269|PubMed:14695977}.
CC   -!- PTM: N-glycosylated. {ECO:0000250}.
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DR   EMBL; AJ515240; CAD56202.1; -; mRNA.
DR   EMBL; BX883045; CAE83992.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q8CHN2; -.
DR   STRING; 10116.ENSRNOP00000001122; -.
DR   GlyGen; Q8CHN2; 1 site.
DR   PaxDb; Q8CHN2; -.
DR   UCSC; RGD:735180; rat.
DR   RGD; 735180; Ly6g5c.
DR   eggNOG; ENOG502TD7Y; Eukaryota.
DR   InParanoid; Q8CHN2; -.
DR   PhylomeDB; Q8CHN2; -.
DR   PRO; PR:Q8CHN2; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0032991; C:protein-containing complex; ISO:RGD.
DR   GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR   InterPro; IPR026110; LY6G5C.
DR   PANTHER; PTHR14909; PTHR14909; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..38
FT                   /evidence="ECO:0000255"
FT   CHAIN           39..145
FT                   /note="Lymphocyte antigen 6 complex locus protein G5c"
FT                   /id="PRO_5000069914"
FT   DOMAIN          55..145
FT                   /note="UPAR/Ly6"
FT   CARBOHYD        91
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        57..84
FT                   /evidence="ECO:0000250"
FT   DISULFID        60..69
FT                   /evidence="ECO:0000250"
FT   DISULFID        76..102
FT                   /evidence="ECO:0000250"
FT   DISULFID        111..128
FT                   /evidence="ECO:0000250"
FT   DISULFID        129..134
FT                   /evidence="ECO:0000250"
FT   CONFLICT        40
FT                   /note="T -> N (in Ref. 2; CAE83992)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   145 AA;  15985 MW;  093A3AFA2CB07800 CRC64;
     MSGLAASWSL KPLGPHGVTQ ALCAVLLAVL VTMNVVLGDT LLDIPSQSPP LNQYLHCYRC
     LLETEELGCL LGSDTCLTPL GSTCVTLHIK NSSGFNVMVS DCRNKEQMVD CSYTRASPVF
     GFWIFYQCCF LDFCNNPKNR KNTMH