LY66C_HUMAN
ID LY66C_HUMAN Reviewed; 125 AA.
AC O95867; Q5SRS8; Q8IY94;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Lymphocyte antigen 6 complex locus protein G6c;
DE Flags: Precursor;
GN Name=LY6G6C; Synonyms=C6orf24, G6C, NG24; ORFNames=UNQ1947/PRO4430;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10384126;
RA Ribas G., Neville M., Wixon J.L., Cheng J., Campbell R.D.;
RT "Genes encoding three new members of the leukocyte antigen 6 superfamily
RT and a novel member of Ig superfamily, together with genes encoding the
RT regulatory nuclear chloride ion channel protein (hRNCC) and an N omega-N
RT omega-dimethylarginine dimethylaminohydrolase homologue, are found in a 30-
RT kb segment of the MHC class III region.";
RL J. Immunol. 163:278-287(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12079290; DOI=10.1006/geno.2002.6794;
RA Mallya M., Campbell R.D., Aguado B.;
RT "Transcriptional analysis of a novel cluster of LY-6 family members in the
RT human and mouse major histocompatibility complex: five genes with many
RT splice forms.";
RL Genomics 80:113-123(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14656967; DOI=10.1101/gr.1736803;
RA Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D.,
RA Hood L.;
RT "Analysis of the gene-dense major histocompatibility complex class III
RT region and its comparison to mouse.";
RL Genome Res. 13:2621-2636(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Shiina S., Tamiya G., Oka A., Inoko H.;
RT "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region.";
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP GLYCOSYLATION, SUBCELLULAR LOCATION, SUBUNIT, GPI-ANCHOR, AND TISSUE
RP SPECIFICITY.
RX PubMed=17008713; DOI=10.1110/ps.062242606;
RA Mallya M., Campbell R.D., Aguado B.;
RT "Characterization of the five novel Ly-6 superfamily members encoded in the
RT MHC, and detection of cells expressing their potential ligands.";
RL Protein Sci. 15:2244-2256(2006).
CC -!- SUBUNIT: Monomer. {ECO:0000269|PubMed:17008713}.
CC -!- INTERACTION:
CC O95867; Q8WVX3-2: C4orf3; NbExp=3; IntAct=EBI-9088345, EBI-12003442;
CC O95867; Q9NVC3: SLC38A7; NbExp=3; IntAct=EBI-9088345, EBI-10314552;
CC O95867; Q9NP94: SLC39A2; NbExp=3; IntAct=EBI-9088345, EBI-12898013;
CC O95867; Q96JW4: SLC41A2; NbExp=3; IntAct=EBI-9088345, EBI-10290130;
CC O95867; Q969S6: TMEM203; NbExp=3; IntAct=EBI-9088345, EBI-12274070;
CC O95867; Q9Y385: UBE2J1; NbExp=3; IntAct=EBI-9088345, EBI-988826;
CC O95867; Q96EC8: YIPF6; NbExp=3; IntAct=EBI-9088345, EBI-751210;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17008713};
CC Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17008713}.
CC -!- TISSUE SPECIFICITY: Highly expressed at the leading edges of cells, on
CC filopodia. {ECO:0000269|PubMed:17008713}.
CC -!- PTM: N-glycosylated. {ECO:0000269|PubMed:17008713}.
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DR EMBL; AJ012008; CAB46081.1; -; Genomic_DNA.
DR EMBL; AJ315533; CAC85539.1; -; mRNA.
DR EMBL; AF129756; AAD18076.1; -; Genomic_DNA.
DR EMBL; BA000025; BAB63379.1; -; Genomic_DNA.
DR EMBL; AY359119; AAQ89477.1; -; mRNA.
DR EMBL; BX248244; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL844216; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR354443; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR936239; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR759787; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471081; EAX03491.1; -; Genomic_DNA.
DR EMBL; BC036302; AAH36302.2; -; mRNA.
DR CCDS; CCDS4714.1; -.
DR RefSeq; NP_079537.1; NM_025261.2.
DR AlphaFoldDB; O95867; -.
DR BioGRID; 123284; 18.
DR IntAct; O95867; 9.
DR STRING; 9606.ENSP00000364978; -.
DR GlyGen; O95867; 1 site.
DR PhosphoSitePlus; O95867; -.
DR BioMuta; LY6G6C; -.
DR MassIVE; O95867; -.
DR PaxDb; O95867; -.
DR PeptideAtlas; O95867; -.
DR PRIDE; O95867; -.
DR ProteomicsDB; 51108; -.
DR Antibodypedia; 27576; 93 antibodies from 18 providers.
DR DNASU; 80740; -.
DR Ensembl; ENST00000375819.3; ENSP00000364978.2; ENSG00000204421.3.
DR Ensembl; ENST00000383413.4; ENSP00000372905.4; ENSG00000206398.5.
DR Ensembl; ENST00000419939.2; ENSP00000388591.2; ENSG00000235452.2.
DR Ensembl; ENST00000428121.2; ENSP00000411365.2; ENSG00000228250.2.
DR Ensembl; ENST00000428498.2; ENSP00000410398.2; ENSG00000228859.2.
DR Ensembl; ENST00000434915.2; ENSP00000415732.2; ENSG00000236183.2.
DR Ensembl; ENST00000448386.2; ENSP00000409428.2; ENSG00000235925.3.
DR GeneID; 80740; -.
DR KEGG; hsa:80740; -.
DR MANE-Select; ENST00000375819.3; ENSP00000364978.2; NM_025261.3; NP_079537.1.
DR UCSC; uc003nwh.4; human.
DR CTD; 80740; -.
DR DisGeNET; 80740; -.
DR GeneCards; LY6G6C; -.
DR HGNC; HGNC:13936; LY6G6C.
DR HPA; ENSG00000204421; Tissue enriched (skin).
DR MIM; 610435; gene.
DR neXtProt; NX_O95867; -.
DR OpenTargets; ENSG00000204421; -.
DR PharmGKB; PA37830; -.
DR VEuPathDB; HostDB:ENSG00000204421; -.
DR eggNOG; ENOG502T0T6; Eukaryota.
DR GeneTree; ENSGT00390000000752; -.
DR HOGENOM; CLU_1991884_0_0_1; -.
DR InParanoid; O95867; -.
DR OMA; YNTTCCS; -.
DR OrthoDB; 1566894at2759; -.
DR PhylomeDB; O95867; -.
DR TreeFam; TF337667; -.
DR PathwayCommons; O95867; -.
DR Reactome; R-HSA-163125; Post-translational modification: synthesis of GPI-anchored proteins.
DR SignaLink; O95867; -.
DR BioGRID-ORCS; 80740; 17 hits in 1067 CRISPR screens.
DR ChiTaRS; LY6G6C; human.
DR GenomeRNAi; 80740; -.
DR Pharos; O95867; Tbio.
DR PRO; PR:O95867; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; O95867; protein.
DR Bgee; ENSG00000204421; Expressed in skin of abdomen and 83 other tissues.
DR ExpressionAtlas; O95867; baseline and differential.
DR Genevisible; O95867; HS.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0032991; C:protein-containing complex; IDA:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; IDA:UniProtKB.
DR InterPro; IPR039237; LY6G6C.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR PANTHER; PTHR32149; PTHR32149; 1.
DR SUPFAM; SSF57302; SSF57302; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein;
KW Membrane; Reference proteome; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..99
FT /note="Lymphocyte antigen 6 complex locus protein G6c"
FT /id="PRO_0000036176"
FT PROPEP 100..125
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000323019"
FT DOMAIN 20..111
FT /note="UPAR/Ly6"
FT LIPID 99
FT /note="GPI-anchor amidated serine"
FT /evidence="ECO:0000255"
FT CARBOHYD 88
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 22..47
FT /evidence="ECO:0000250"
FT DISULFID 25..33
FT /evidence="ECO:0000250"
FT DISULFID 39..65
FT /evidence="ECO:0000250"
FT DISULFID 92..97
FT /evidence="ECO:0000250"
FT VARIANT 63
FT /note="L -> M (in dbSNP:rs13214568)"
FT /id="VAR_039541"
SQ SEQUENCE 125 AA; 13821 MW; 9ED7549894C71311 CRC64;
MKALMLLTLS VLLCWVSADI RCHSCYKVPV LGCVDRQSCR LEPGQQCLTT HAYLGKMWVF
SNLRCGTPEE PCQEAFNQTN RKLGLTYNTT CCNKDNCNSA GPRPTPALGL VFLTSLAGLG
LWLLH
