ID   LY66C_MOUSE             Reviewed;         126 AA.
AC   Q9Z1Q4;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1999, sequence version 1.
DT   03-AUG-2022, entry version 130.
DE   RecName: Full=Lymphocyte antigen 6 complex locus protein G6c;
DE   Flags: Precursor;
GN   Name=Ly6g6c; Synonyms=Ng24;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=129;
RX   PubMed=14656967; DOI=10.1101/gr.1736803;
RA   Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D.,
RA   Hood L.;
RT   "Analysis of the gene-dense major histocompatibility complex class III
RT   region and its comparison to mouse.";
RL   Genome Res. 13:2621-2636(2003).
RN   [2]
RP   GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-89.
RC   TISSUE=Epidermis;
RX   PubMed=16170054; DOI=10.1074/mcp.m500203-mcp200;
RA   Uematsu R., Furukawa J., Nakagawa H., Shinohara Y., Deguchi K., Monde K.,
RA   Nishimura S.;
RT   "High throughput quantitative glycomics and glycoform-focused proteomics of
RT   murine dermis and epidermis.";
RL   Mol. Cell. Proteomics 4:1977-1989(2005).
RN   [3]
RP   GLYCOSYLATION, SUBCELLULAR LOCATION, SUBUNIT, GPI-ANCHOR, AND TISSUE
RP   SPECIFICITY.
RX   PubMed=17008713; DOI=10.1110/ps.062242606;
RA   Mallya M., Campbell R.D., Aguado B.;
RT   "Characterization of the five novel Ly-6 superfamily members encoded in the
RT   MHC, and detection of cells expressing their potential ligands.";
RL   Protein Sci. 15:2244-2256(2006).
CC   -!- SUBUNIT: Monomer. {ECO:0000269|PubMed:17008713}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-
CC       anchor {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Highly expressed at the leading edges of cells, on
CC       filopodia. {ECO:0000269|PubMed:17008713}.
CC   -!- PTM: N-glycosylated. {ECO:0000269|PubMed:16170054,
CC       ECO:0000269|PubMed:17008713}.
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DR   EMBL; AF109905; AAC84157.1; -; Genomic_DNA.
DR   CCDS; CCDS28677.1; -.
DR   RefSeq; NP_075952.1; NM_023463.3.
DR   AlphaFoldDB; Q9Z1Q4; -.
DR   STRING; 10090.ENSMUSP00000133510; -.
DR   GlyGen; Q9Z1Q4; 1 site.
DR   iPTMnet; Q9Z1Q4; -.
DR   PhosphoSitePlus; Q9Z1Q4; -.
DR   PaxDb; Q9Z1Q4; -.
DR   PRIDE; Q9Z1Q4; -.
DR   ProteomicsDB; 290195; -.
DR   Antibodypedia; 27576; 93 antibodies from 18 providers.
DR   DNASU; 68468; -.
DR   Ensembl; ENSMUST00000173478; ENSMUSP00000133510; ENSMUSG00000092586.
DR   GeneID; 68468; -.
DR   KEGG; mmu:68468; -.
DR   UCSC; uc008cfm.1; mouse.
DR   CTD; 80740; -.
DR   MGI; MGI:2148930; Ly6g6c.
DR   VEuPathDB; HostDB:ENSMUSG00000092586; -.
DR   eggNOG; ENOG502T0T6; Eukaryota.
DR   GeneTree; ENSGT00390000000752; -.
DR   HOGENOM; CLU_1991884_0_0_1; -.
DR   InParanoid; Q9Z1Q4; -.
DR   OrthoDB; 1566894at2759; -.
DR   PhylomeDB; Q9Z1Q4; -.
DR   TreeFam; TF337667; -.
DR   Reactome; R-MMU-163125; Post-translational modification: synthesis of GPI-anchored proteins.
DR   BioGRID-ORCS; 68468; 1 hit in 75 CRISPR screens.
DR   ChiTaRS; Ly6g6c; mouse.
DR   PRO; PR:Q9Z1Q4; -.
DR   Proteomes; UP000000589; Chromosome 17.
DR   RNAct; Q9Z1Q4; protein.
DR   Bgee; ENSMUSG00000092586; Expressed in lip and 50 other tissues.
DR   ExpressionAtlas; Q9Z1Q4; baseline and differential.
DR   Genevisible; Q9Z1Q4; MM.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009897; C:external side of plasma membrane; ISO:MGI.
DR   GO; GO:0032991; C:protein-containing complex; IDA:UniProtKB.
DR   GO; GO:0042802; F:identical protein binding; IDA:UniProtKB.
DR   GO; GO:0009617; P:response to bacterium; IEP:MGI.
DR   InterPro; IPR039237; LY6G6C.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   PANTHER; PTHR32149; PTHR32149; 1.
DR   SUPFAM; SSF57302; SSF57302; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein;
KW   Membrane; Reference proteome; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..100
FT                   /note="Lymphocyte antigen 6 complex locus protein G6c"
FT                   /id="PRO_0000036177"
FT   PROPEP          101..126
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000323020"
FT   DOMAIN          21..112
FT                   /note="UPAR/Ly6"
FT   LIPID           100
FT                   /note="GPI-anchor amidated serine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        89
FT                   /note="N-linked (GlcNAc...) (high mannose) asparagine"
FT                   /evidence="ECO:0000269|PubMed:16170054"
FT   DISULFID        23..48
FT                   /evidence="ECO:0000250"
FT   DISULFID        26..34
FT                   /evidence="ECO:0000250"
FT   DISULFID        40..66
FT                   /evidence="ECO:0000250"
FT   DISULFID        93..98
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   126 AA;  14066 MW;  6D8611F9E83B97ED CRC64;
     MKHLLLLTLS ALLYCWVSAD TRCHSCYKVP VLGCVDRQSC RLEPGHKCLT TNVYLGKMWV
     FSNLRCGTPE EPCREVFNET NHKLGLNYNT TCCDKDNCNS PAPRPTPALA LISLTSLAGL
     GLWLLH