LY66D_MOUSE
ID LY66D_MOUSE Reviewed; 135 AA.
AC Q9Z1Q3;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Lymphocyte antigen 6 complex locus protein G6d;
DE Flags: Precursor;
GN Name=Ly6g6d; Synonyms=Ng25;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=129;
RX PubMed=12079290; DOI=10.1006/geno.2002.6794;
RA Mallya M., Campbell R.D., Aguado B.;
RT "Transcriptional analysis of a novel cluster of LY-6 family members in the
RT human and mouse major histocompatibility complex: five genes with many
RT splice forms.";
RL Genomics 80:113-123(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=129;
RX PubMed=14656967; DOI=10.1101/gr.1736803;
RA Xie T., Rowen L., Aguado B., Ahearn M.E., Madan A., Qin S., Campbell R.D.,
RA Hood L.;
RT "Analysis of the gene-dense major histocompatibility complex class III
RT region and its comparison to mouse.";
RL Genome Res. 13:2621-2636(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP GLYCOSYLATION, SUBCELLULAR LOCATION, SUBUNIT, AND GPI-ANCHOR.
RX PubMed=17008713; DOI=10.1110/ps.062242606;
RA Mallya M., Campbell R.D., Aguado B.;
RT "Characterization of the five novel Ly-6 superfamily members encoded in the
RT MHC, and detection of cells expressing their potential ligands.";
RL Protein Sci. 15:2244-2256(2006).
CC -!- SUBUNIT: Homodimer. {ECO:0000269|PubMed:17008713}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:17008713};
CC Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:17008713}. Cell
CC projection, filopodium {ECO:0000269|PubMed:17008713}.
CC -!- TISSUE SPECIFICITY: Expressed in embryonic tissue and adult lung,
CC kidney, brain, liver and spleen. {ECO:0000269|PubMed:12079290}.
CC -!- PTM: O-glycosylated. {ECO:0000269|PubMed:17008713}.
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DR EMBL; AJ315548; CAC85545.1; -; mRNA.
DR EMBL; AF109905; AAC84158.1; -; Genomic_DNA.
DR EMBL; BC131988; AAI31989.1; -; mRNA.
DR EMBL; BC131990; AAI31991.1; -; mRNA.
DR CCDS; CCDS28678.1; -.
DR RefSeq; NP_258439.1; NM_033478.2.
DR AlphaFoldDB; Q9Z1Q3; -.
DR STRING; 10090.ENSMUSP00000007259; -.
DR GlyGen; Q9Z1Q3; 1 site.
DR iPTMnet; Q9Z1Q3; -.
DR PhosphoSitePlus; Q9Z1Q3; -.
DR PaxDb; Q9Z1Q3; -.
DR PRIDE; Q9Z1Q3; -.
DR ProteomicsDB; 292057; -.
DR ABCD; Q9Z1Q3; 11 sequenced antibodies.
DR Antibodypedia; 50491; 104 antibodies from 14 providers.
DR Ensembl; ENSMUST00000007259; ENSMUSP00000007259; ENSMUSG00000073413.
DR GeneID; 114654; -.
DR KEGG; mmu:114654; -.
DR UCSC; uc008cfn.1; mouse.
DR CTD; 58530; -.
DR MGI; MGI:2148931; Ly6g6d.
DR VEuPathDB; HostDB:ENSMUSG00000073413; -.
DR eggNOG; ENOG502SNF5; Eukaryota.
DR GeneTree; ENSGT00390000015960; -.
DR HOGENOM; CLU_1824727_0_0_1; -.
DR InParanoid; Q9Z1Q3; -.
DR OMA; QHQPACV; -.
DR OrthoDB; 1493078at2759; -.
DR PhylomeDB; Q9Z1Q3; -.
DR Reactome; R-MMU-163125; Post-translational modification: synthesis of GPI-anchored proteins.
DR BioGRID-ORCS; 114654; 4 hits in 73 CRISPR screens.
DR PRO; PR:Q9Z1Q3; -.
DR Proteomes; UP000000589; Chromosome 17.
DR RNAct; Q9Z1Q3; protein.
DR Bgee; ENSMUSG00000073413; Expressed in lip and 69 other tissues.
DR Genevisible; Q9Z1Q3; MM.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009897; C:external side of plasma membrane; ISO:MGI.
DR GO; GO:0030175; C:filopodium; IEA:UniProtKB-SubCell.
DR GO; GO:0032991; C:protein-containing complex; IDA:UniProtKB.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IDA:MGI.
DR GO; GO:0042802; F:identical protein binding; IDA:UniProtKB.
DR GO; GO:0095500; P:acetylcholine receptor signaling pathway; IDA:MGI.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR026524; LY6G6d/LY6G6f.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR PANTHER; PTHR32286; PTHR32286; 1.
DR SUPFAM; SSF57302; SSF57302; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Cell projection; Disulfide bond; Glycoprotein; GPI-anchor;
KW Lipoprotein; Membrane; Reference proteome; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..108
FT /note="Lymphocyte antigen 6 complex locus protein G6d"
FT /id="PRO_0000323709"
FT PROPEP 109..135
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000323710"
FT DOMAIN 22..121
FT /note="UPAR/Ly6"
FT LIPID 108
FT /note="GPI-anchor amidated asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 68
FT /note="O-linked (GalNAc...) threonine"
FT /evidence="ECO:0000255"
FT DISULFID 24..48
FT /evidence="ECO:0000250"
FT DISULFID 27..35
FT /evidence="ECO:0000250"
FT DISULFID 42..76
FT /evidence="ECO:0000250"
FT DISULFID 82..101
FT /evidence="ECO:0000250"
FT DISULFID 102..107
FT /evidence="ECO:0000250"
SQ SEQUENCE 135 AA; 14092 MW; 22EF132D41F438FF CRC64;
MNSQLVGILL SALLGVALGH RTRCYDCGGG PSNSCKQTVI TCGEGERCGF LDRKPQPSSE
QAKQPSATLS HHYPACVATH HCNQVAIESV GDVTFTTQKN CCFGDLCNSA VASSVTPLCI
LAAAVTTLAW LLPGL
