ID   LY66F_BOVIN             Reviewed;         299 AA.
AC   Q0V881;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Lymphocyte antigen 6 complex locus protein G6f;
DE   Flags: Precursor;
GN   Name=LY6G6F; Synonyms=G6F;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RX   PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA   Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA   Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT   "Characterization of 954 bovine full-CDS cDNA sequences.";
RL   BMC Genomics 6:166-166(2005).
CC   -!- FUNCTION: May play a role in the downstream signal transduction
CC       pathways involving GRB2 and GRB7. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. Interacts with GRB2 and GRB7 in a
CC       phosphorylation-dependent manner (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}.
CC   -!- PTM: N-glycosylated. {ECO:0000250}.
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DR   EMBL; BT026338; ABG81494.1; -; mRNA.
DR   RefSeq; NP_001069662.1; NM_001076194.1.
DR   AlphaFoldDB; Q0V881; -.
DR   STRING; 9913.ENSBTAP00000000757; -.
DR   PaxDb; Q0V881; -.
DR   GeneID; 539920; -.
DR   KEGG; bta:539920; -.
DR   CTD; 259215; -.
DR   eggNOG; ENOG502SNF5; Eukaryota.
DR   InParanoid; Q0V881; -.
DR   OrthoDB; 945228at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR026524; LY6G6d/LY6G6f.
DR   PANTHER; PTHR32286; PTHR32286; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW   Membrane; Phosphoprotein; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..299
FT                   /note="Lymphocyte antigen 6 complex locus protein G6f"
FT                   /id="PRO_0000318922"
FT   TOPO_DOM        20..237
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..299
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          20..124
FT                   /note="Ig-like V-type"
FT   MOD_RES         283
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5SQ64"
FT   CARBOHYD        90
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        37..108
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   299 AA;  32432 MW;  419C7B3D1408562F CRC64;
     MAVLFLLLLF LCGLPQAETD SIQAIYVVLG EALELPCPSP PALNGDEFLS WFHSPAAGSS
     TALVAHVQVA RPSRDPGKPR RESRLTLLGN YSLWLEGSKA GDAGRYWCAL LGQRYRYQNW
     RVYDVSVLRG SQFSARAADG SSCSVLLCSV VPARSLDSVT WQEGKGPVKG DVQSFWGDGA
     TLLLMCPGEG LPEPRAHKPG IIRCLVPQNK GISFSLAAST DASPALCAPS ADWDVAWILT
     LLLTVGQGFT IVVLGVMLWR QRAQGAQHRN ASFPQFKPEI QVYENIHLAH LSPPAPKTR