ID   LY66F_RAT               Reviewed;         293 AA.
AC   Q6MG56;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 104.
DE   RecName: Full=Lymphocyte antigen 6 complex locus protein G6f;
DE   Flags: Precursor;
GN   Name=Ly6g6f; Synonyms=G6f;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway;
RX   PubMed=15060004; DOI=10.1101/gr.1987704;
RA   Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H.,
RA   Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.;
RT   "The genomic sequence and comparative analysis of the rat major
RT   histocompatibility complex.";
RL   Genome Res. 14:631-639(2004).
CC   -!- FUNCTION: May play a role in the downstream signal transduction
CC       pathways involving GRB2 and GRB7. {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. Interacts with GRB2 and GRB7 in a
CC       phosphorylation-dependent manner (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC       membrane protein {ECO:0000250}.
CC   -!- PTM: N-glycosylated. {ECO:0000250}.
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DR   EMBL; BX883045; CAE83990.1; -; Genomic_DNA.
DR   RefSeq; NP_001003691.1; NM_001003691.1.
DR   AlphaFoldDB; Q6MG56; -.
DR   STRING; 10116.ENSRNOP00000068053; -.
DR   GlyGen; Q6MG56; 1 site.
DR   PhosphoSitePlus; Q6MG56; -.
DR   PaxDb; Q6MG56; -.
DR   GeneID; 309609; -.
DR   KEGG; rno:309609; -.
DR   UCSC; RGD:1303333; rat.
DR   CTD; 259215; -.
DR   RGD; 1303333; Ly6g6f.
DR   eggNOG; ENOG502SNF5; Eukaryota.
DR   InParanoid; Q6MG56; -.
DR   PhylomeDB; Q6MG56; -.
DR   Reactome; R-RNO-114608; Platelet degranulation.
DR   PRO; PR:Q6MG56; -.
DR   Proteomes; UP000002494; Unplaced.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR013106; Ig_V-set.
DR   InterPro; IPR026524; LY6G6d/LY6G6f.
DR   PANTHER; PTHR32286; PTHR32286; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS50835; IG_LIKE; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; Glycoprotein; Immunoglobulin domain;
KW   Membrane; Phosphoprotein; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000255"
FT   CHAIN           20..293
FT                   /note="Lymphocyte antigen 6 complex locus protein G6f"
FT                   /id="PRO_0000318924"
FT   TOPO_DOM        20..237
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        238..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        259..293
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          20..124
FT                   /note="Ig-like V-type"
FT   MOD_RES         284
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q5SQ64"
FT   CARBOHYD        90
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        37..108
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ   SEQUENCE   293 AA;  32615 MW;  F079E45DA6A9A146 CRC64;
     MAMVVFLLLY LCGHPQAAAD NIQTLYVPSG ESMEMPCPSP PSLLGGQLLT WFRSPVSGSS
     TILVAQVQVD RPISDLGKAD PDSRFKVLGN YSLRLEGSRD EDAGRYWCTV MDQNHKYQNW
     RVYDVSVLKG SQFSVKSPDG LSCSALLCSV VPARRLDSVT WLEGRNPVRG HAQYFWGEGA
     ALLLVCPTEG VPETRSRRPR NIRCLMPQNK RFSFSVAAPA EPPPTVCAPL PSWDVSWILM
     LLFAAGQGVT IIALSIVIWR HQRAQGTQDR EPSIPHFKPE VQVYENIHLA RLR