ID   LY6B_RAT                Reviewed;         135 AA.
AC   Q63317;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Lymphocyte antigen 6B;
DE            Short=Ly-6B;
DE   Flags: Precursor;
GN   Name=Ly6b;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2154400; DOI=10.1007/bf00661220;
RA   Friedman S., Palfree R.G., Sirlin S., Hammerling U.;
RT   "Analysis of three distinct Ly6-A-related cDNA sequences isolated from rat
RT   kidney.";
RL   Immunogenetics 31:104-111(1990).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC       anchor {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; M30689; AAA41546.1; -; mRNA.
DR   PIR; A45835; A45835.
DR   RefSeq; NP_640350.1; NM_139257.1.
DR   RefSeq; XP_006241827.1; XM_006241765.3.
DR   RefSeq; XP_006241828.1; XM_006241766.3.
DR   RefSeq; XP_008763767.1; XM_008765545.2.
DR   AlphaFoldDB; Q63317; -.
DR   SMR; Q63317; -.
DR   STRING; 10116.ENSRNOP00000068186; -.
DR   iPTMnet; Q63317; -.
DR   PhosphoSitePlus; Q63317; -.
DR   PaxDb; Q63317; -.
DR   Ensembl; ENSRNOT00000009395; ENSRNOP00000009395; ENSRNOG00000007137.
DR   GeneID; 246138; -.
DR   KEGG; rno:246138; -.
DR   UCSC; RGD:628818; rat.
DR   CTD; 57248; -.
DR   RGD; 628818; Ly6b.
DR   eggNOG; ENOG502TD4F; Eukaryota.
DR   GeneTree; ENSGT00940000154560; -.
DR   HOGENOM; CLU_106772_0_0_1; -.
DR   InParanoid; Q63317; -.
DR   OMA; KISCCKE; -.
DR   OrthoDB; 1586315at2759; -.
DR   PhylomeDB; Q63317; -.
DR   TreeFam; TF337757; -.
DR   PRO; PR:Q63317; -.
DR   Proteomes; UP000002494; Chromosome 7.
DR   Bgee; ENSRNOG00000007137; Expressed in lung and 12 other tissues.
DR   Genevisible; Q63317; RN.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0033130; F:acetylcholine receptor binding; IBA:GO_Central.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IBA:GO_Central.
DR   GO; GO:0095500; P:acetylcholine receptor signaling pathway; IBA:GO_Central.
DR   CDD; cd00117; LU; 1.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR016054; LY6_UPA_recep-like.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   Pfam; PF00021; UPAR_LY6; 1.
DR   SMART; SM00134; LU; 1.
DR   SUPFAM; SSF57302; SSF57302; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein;
KW   Membrane; Reference proteome; Signal.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..113
FT                   /note="Lymphocyte antigen 6B"
FT                   /id="PRO_0000318209"
FT   PROPEP          114..135
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000318210"
FT   DOMAIN          27..119
FT                   /note="UPAR/Ly6"
FT   LIPID           113
FT                   /note="GPI-anchor amidated glycine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        29..54
FT                   /evidence="ECO:0000250"
FT   DISULFID        32..41
FT                   /evidence="ECO:0000250"
FT   DISULFID        47..75
FT                   /evidence="ECO:0000250"
FT   DISULFID        79..99
FT                   /evidence="ECO:0000250"
FT   DISULFID        100..105
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   135 AA;  14130 MW;  E4D6ADC56B61A053 CRC64;
     MNRSCAMKSC VLILLLALLC AERAQGLNCY NCTMIPFGNT CSSTATCPYP DGVCTIQVAE
     VVVSSVRLKV KSNLCLPGCP KSPQTPEVLG TVVHVNTDCC NTDLCNAAGP TGGSTWTMAG
     VLLFILGSVL LQTLL