LY6C1_MOUSE
ID LY6C1_MOUSE Reviewed; 131 AA.
AC P0CW02; P09568; Q58E40; Q8C2D8; Q91XG0;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 03-MAY-2011, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Lymphocyte antigen 6C1;
DE Short=Ly-6C1;
DE Flags: Precursor;
GN Name=Ly6c1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=3356904;
RA Bothwell A.L.M., Pace P.E., Leclair K.P.;
RT "Isolation and expression of an IFN-responsive Ly-6C chromosomal gene.";
RL J. Immunol. 140:2815-2820(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Spleen, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC anchor {ECO:0000305}.
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DR EMBL; M21734; AAA39469.1; -; Genomic_DNA.
DR EMBL; M21771; AAA39469.1; JOINED; Genomic_DNA.
DR EMBL; M21733; AAA39469.1; JOINED; Genomic_DNA.
DR EMBL; AK088782; BAC40570.1; -; mRNA.
DR EMBL; AK143577; BAE25446.1; -; mRNA.
DR EMBL; BC010764; AAH10764.1; -; mRNA.
DR CCDS; CCDS27541.1; -.
DR RefSeq; NP_001238984.1; NM_001252055.1.
DR RefSeq; NP_034871.2; NM_010741.3.
DR RefSeq; XP_006520584.1; XM_006520521.3.
DR AlphaFoldDB; P0CW02; -.
DR STRING; 10090.ENSMUSP00000066954; -.
DR SwissPalm; P0CW02; -.
DR jPOST; P0CW02; -.
DR MaxQB; P0CW02; -.
DR PaxDb; P0CW02; -.
DR PeptideAtlas; P0CW02; -.
DR PRIDE; P0CW02; -.
DR ProteomicsDB; 291971; -.
DR DNASU; 17067; -.
DR Ensembl; ENSMUST00000065408; ENSMUSP00000066954; ENSMUSG00000079018.
DR Ensembl; ENSMUST00000179762; ENSMUSP00000137401; ENSMUSG00000079018.
DR Ensembl; ENSMUST00000187347; ENSMUSP00000139799; ENSMUSG00000079018.
DR GeneID; 17067; -.
DR KEGG; mmu:17067; -.
DR UCSC; uc007wgn.2; mouse.
DR CTD; 17067; -.
DR MGI; MGI:96882; Ly6c1.
DR VEuPathDB; HostDB:ENSMUSG00000079018; -.
DR eggNOG; ENOG502TD4F; Eukaryota.
DR GeneTree; ENSGT00940000154560; -.
DR HOGENOM; CLU_106772_0_0_1; -.
DR InParanoid; P0CW02; -.
DR PhylomeDB; P0CW02; -.
DR TreeFam; TF337757; -.
DR BioGRID-ORCS; 17067; 3 hits in 40 CRISPR screens.
DR ChiTaRS; Ly6c1; mouse.
DR PRO; PR:P0CW02; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; P0CW02; protein.
DR Bgee; ENSMUSG00000079018; Expressed in synovial joint and 66 other tissues.
DR ExpressionAtlas; P0CW02; baseline and differential.
DR Genevisible; P0CW02; MM.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009986; C:cell surface; IDA:MGI.
DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0033130; F:acetylcholine receptor binding; IBA:GO_Central.
DR GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IBA:GO_Central.
DR GO; GO:0095500; P:acetylcholine receptor signaling pathway; IBA:GO_Central.
DR CDD; cd00117; LU; 1.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR018363; CD59_antigen_CS.
DR InterPro; IPR016054; LY6_UPA_recep-like.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR Pfam; PF00021; UPAR_LY6; 1.
DR SMART; SM00134; LU; 1.
DR SUPFAM; SSF57302; SSF57302; 1.
DR PROSITE; PS00983; LY6_UPAR; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein;
KW Membrane; Reference proteome; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..109
FT /note="Lymphocyte antigen 6C1"
FT /id="PRO_0000408033"
FT PROPEP 110..131
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000408034"
FT DOMAIN 27..115
FT /note="UPAR/Ly6"
FT LIPID 109
FT /note="GPI-anchor amidated glycine"
FT /evidence="ECO:0000255"
FT DISULFID 29..53
FT /evidence="ECO:0000250"
FT DISULFID 32..41
FT /evidence="ECO:0000250"
FT DISULFID 46..74
FT /evidence="ECO:0000250"
FT DISULFID 78..95
FT /evidence="ECO:0000250"
FT DISULFID 96..101
FT /evidence="ECO:0000250"
FT CONFLICT 3..4
FT /note="TS -> ST (in Ref. 1; AAA39469)"
FT /evidence="ECO:0000305"
FT CONFLICT 6
FT /note="T -> A (in Ref. 1; AAA39469)"
FT /evidence="ECO:0000305"
FT CONFLICT 11
FT /note="V -> L (in Ref. 1; AAA39469)"
FT /evidence="ECO:0000305"
FT CONFLICT 22
FT /note="E -> G (in Ref. 1; AAA39469 and 2; BAC40570)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 131 AA; 14193 MW; 36DAB8CB8F137CB0 CRC64;
MDTSHTTKSC VLILLVALLC AERAQGLQCY ECYGVPIETS CPAVTCRASD GFCIAQNIEL
IEDSQRRKLK TRQCLSFCPA GVPIRDPNIR ERTSCCSEDL CNAAVPTAGS TWTMAGVLLF
SLSSVVLQTL L
