LY6C2_MOUSE
ID LY6C2_MOUSE Reviewed; 131 AA.
AC P0CW03; P09568; Q58E40; Q8C2D8;
DT 03-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 03-MAY-2011, sequence version 1.
DT 03-AUG-2022, entry version 59.
DE RecName: Full=Lymphocyte antigen 6C2;
DE Short=Ly-6C2;
DE Flags: Precursor;
GN Name=Ly6c2; Synonyms=Ly6c;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RX PubMed=3335781;
RA Palfree R.G.E., Sirlin S., Dumont F.J., Haemmerling U.;
RT "N-terminal and cDNA characterization of murine lymphocyte antigen Ly-
RT 6C.2.";
RL J. Immunol. 140:305-310(1988).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC anchor {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; M18466; AAA39466.1; -; mRNA.
DR EMBL; BC092082; AAH92082.1; -; mRNA.
DR CCDS; CCDS49638.1; -.
DR PIR; I56012; I56012.
DR RefSeq; NP_001092687.1; NM_001099217.1.
DR RefSeq; XP_011243692.1; XM_011245390.2.
DR RefSeq; XP_011243693.1; XM_011245391.2.
DR AlphaFoldDB; P0CW03; -.
DR STRING; 10090.ENSMUSP00000140825; -.
DR SwissPalm; P0CW03; -.
DR EPD; P0CW03; -.
DR jPOST; P0CW03; -.
DR MaxQB; P0CW03; -.
DR PaxDb; P0CW03; -.
DR PeptideAtlas; P0CW03; -.
DR PRIDE; P0CW03; -.
DR ProteomicsDB; 287276; -.
DR Ensembl; ENSMUST00000100542; ENSMUSP00000098110; ENSMUSG00000022584.
DR Ensembl; ENSMUST00000188214; ENSMUSP00000140825; ENSMUSG00000022584.
DR Ensembl; ENSMUST00000191451; ENSMUSP00000139556; ENSMUSG00000022584.
DR GeneID; 100041546; -.
DR KEGG; mmu:100041546; -.
DR UCSC; uc007wgp.1; mouse.
DR CTD; 100041546; -.
DR MGI; MGI:3712069; Ly6c2.
DR VEuPathDB; HostDB:ENSMUSG00000022584; -.
DR eggNOG; ENOG502TD4F; Eukaryota.
DR GeneTree; ENSGT00940000154560; -.
DR HOGENOM; CLU_106772_0_0_1; -.
DR InParanoid; P0CW03; -.
DR OrthoDB; 1485195at2759; -.
DR PhylomeDB; P0CW03; -.
DR TreeFam; TF337757; -.
DR BioGRID-ORCS; 100041546; 5 hits in 39 CRISPR screens.
DR ChiTaRS; Ly6c2; mouse.
DR PRO; PR:P0CW03; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; P0CW03; protein.
DR Bgee; ENSMUSG00000022584; Expressed in granulocyte and 53 other tissues.
DR Genevisible; P0CW03; MM.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009986; C:cell surface; IDA:MGI.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0033130; F:acetylcholine receptor binding; IBA:GO_Central.
DR GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IBA:GO_Central.
DR GO; GO:0095500; P:acetylcholine receptor signaling pathway; IBA:GO_Central.
DR CDD; cd00117; LU; 1.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR018363; CD59_antigen_CS.
DR InterPro; IPR016054; LY6_UPA_recep-like.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR Pfam; PF00021; UPAR_LY6; 1.
DR SMART; SM00134; LU; 1.
DR SUPFAM; SSF57302; SSF57302; 1.
DR PROSITE; PS00983; LY6_UPAR; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Direct protein sequencing; Disulfide bond; Glycoprotein;
KW GPI-anchor; Lipoprotein; Membrane; Reference proteome; Signal.
FT SIGNAL 1..26
FT CHAIN 27..109
FT /note="Lymphocyte antigen 6C2"
FT /id="PRO_0000036132"
FT PROPEP 110..131
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000036133"
FT DOMAIN 27..116
FT /note="UPAR/Ly6"
FT LIPID 109
FT /note="GPI-anchor amidated glycine"
FT /evidence="ECO:0000255"
FT DISULFID 29..53
FT /evidence="ECO:0000250"
FT DISULFID 32..41
FT /evidence="ECO:0000250"
FT DISULFID 46..74
FT /evidence="ECO:0000250"
FT DISULFID 78..95
FT /evidence="ECO:0000250"
FT DISULFID 96..101
FT /evidence="ECO:0000250"
SQ SEQUENCE 131 AA; 14090 MW; EB8B9DA9C7EE2C51 CRC64;
MDSTHATKSC LLILLVALLC AGRAQGLQCY ECYGVPIETS CPAVTCRASD GFCIAQNIEL
IEDSQRRKLK TRQCLSFCPA GVPIKDPNIR ERTSCCSEDL CNAAVPTAGS TWTMAGVLLF
SLSSVILQTL L
