ID   LY6D_BOVIN              Reviewed;         128 AA.
AC   Q148C3;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Lymphocyte antigen 6D;
DE            Short=Ly-6D;
DE   Flags: Precursor;
GN   Name=LY6D;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal skin;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a specification marker at earliest stage
CC       specification of lymphocytes between B- and T-cell development. Marks
CC       the earliest stage of B-cell specification (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-
CC       anchor {ECO:0000250}.
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DR   EMBL; BC118490; AAI18491.1; -; mRNA.
DR   RefSeq; NP_001069985.1; NM_001076517.1.
DR   AlphaFoldDB; Q148C3; -.
DR   SMR; Q148C3; -.
DR   STRING; 9913.ENSBTAP00000045838; -.
DR   PaxDb; Q148C3; -.
DR   Ensembl; ENSBTAT00000048872; ENSBTAP00000045838; ENSBTAG00000034498.
DR   GeneID; 618714; -.
DR   KEGG; bta:618714; -.
DR   CTD; 8581; -.
DR   VEuPathDB; HostDB:ENSBTAG00000034498; -.
DR   VGNC; VGNC:31088; LY6D.
DR   eggNOG; ENOG502SGKP; Eukaryota.
DR   GeneTree; ENSGT00730000111514; -.
DR   HOGENOM; CLU_161471_0_0_1; -.
DR   InParanoid; Q148C3; -.
DR   OMA; LRCHVCT; -.
DR   OrthoDB; 1544899at2759; -.
DR   TreeFam; TF336080; -.
DR   Proteomes; UP000009136; Chromosome 14.
DR   Bgee; ENSBTAG00000034498; Expressed in surface of tongue and 50 other tissues.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0030098; P:lymphocyte differentiation; IBA:GO_Central.
DR   GO; GO:0035634; P:response to stilbenoid; IEA:Ensembl.
DR   CDD; cd00117; LU; 1.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR018363; CD59_antigen_CS.
DR   InterPro; IPR016054; LY6_UPA_recep-like.
DR   InterPro; IPR042339; Ly6D.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   InterPro; IPR035076; Toxin/TOLIP.
DR   PANTHER; PTHR16982; PTHR16982; 1.
DR   Pfam; PF00087; Toxin_TOLIP; 1.
DR   SMART; SM00134; LU; 1.
DR   SUPFAM; SSF57302; SSF57302; 1.
DR   PROSITE; PS00983; LY6_UPAR; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein;
KW   Membrane; Reference proteome; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..98
FT                   /note="Lymphocyte antigen 6D"
FT                   /id="PRO_0000318204"
FT   PROPEP          99..128
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000318205"
FT   DOMAIN          21..108
FT                   /note="UPAR/Ly6"
FT   LIPID           98
FT                   /note="GPI-anchor amidated serine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        23..45
FT                   /evidence="ECO:0000250"
FT   DISULFID        26..32
FT                   /evidence="ECO:0000250"
FT   DISULFID        38..63
FT                   /evidence="ECO:0000250"
FT   DISULFID        67..86
FT                   /evidence="ECO:0000250"
FT   DISULFID        87..92
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   128 AA;  13365 MW;  31327A4044797EDE CRC64;
     MKTVLLFLVA LAAAAGPAQA LRCHVCTSSS NCKKPQVCSA SSSFCKTVIR VEPLSGNLVE
     KNCSVWCTPT NNQQGQVSKG QETTLCCNSD LCNEALQSWQ SAAPARTSAH LGLALACGLL
     ALLWAPGL