LY6D_HUMAN
ID LY6D_HUMAN Reviewed; 128 AA.
AC Q14210; B2R5F1; D3DWJ0; O43783; Q6GTV9; Q8TBD4; Q92933;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 1.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Lymphocyte antigen 6D;
DE Short=Ly-6D;
DE AltName: Full=E48 antigen;
DE Flags: Precursor;
GN Name=LY6D; Synonyms=E48;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 21-33, AND GPI-ANCHOR.
RX PubMed=7790363; DOI=10.1083/jcb.129.6.1677;
RA Brakenhoff R.H., Gerretsen M., Knippels E.M.C., van Dijk M., van Essen H.,
RA Weghuis D.O., Sinke R.J., Snow G.B., van Dongen G.A.M.S.;
RT "The human E48 antigen, highly homologous to the murine Ly-6 antigen ThB,
RT is a GPI-anchored molecule apparently involved in keratinocyte cell-cell
RT adhesion.";
RL J. Cell Biol. 129:1677-1689(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT THR-10.
RX PubMed=9366413;
RA Brakenhoff R.H., van Dijk M., Rood-Knippels E.M.C., Snow G.B.;
RT "A gain of novel tissue specificity in the human Ly-6 gene E48.";
RL J. Immunol. 159:4879-4886(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT THR-10.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 18-96.
RX PubMed=9551972;
RA Shan X., Bourdeau A., Rhoton A., Wells D.E., Cohen E.H., Landgraf B.E.,
RA Palfree R.G.E.;
RT "Characterization and mapping to human chromosome 8q24.3 of Ly-6-related
RT gene 9804 encoding an apparent homologue of mouse TSA-1.";
RL J. Immunol. 160:197-208(1998).
RN [7]
RP PROTEIN SEQUENCE OF 21-35.
RX PubMed=15340161; DOI=10.1110/ps.04682504;
RA Zhang Z., Henzel W.J.;
RT "Signal peptide prediction based on analysis of experimentally verified
RT cleavage sites.";
RL Protein Sci. 13:2819-2824(2004).
CC -!- FUNCTION: May act as a specification marker at earliest stage
CC specification of lymphocytes between B- and T-cell development. Marks
CC the earliest stage of B-cell specification.
CC -!- INTERACTION:
CC Q14210; Q13520: AQP6; NbExp=3; IntAct=EBI-1965225, EBI-13059134;
CC Q14210; Q9GZR5: ELOVL4; NbExp=3; IntAct=EBI-1965225, EBI-18535450;
CC Q14210; Q8N661: TMEM86B; NbExp=3; IntAct=EBI-1965225, EBI-2548832;
CC -!- SUBCELLULAR LOCATION: Cell membrane; Lipid-anchor, GPI-anchor.
CC -!- TISSUE SPECIFICITY: Expressed exclusively at the outer cell surface of
CC transitional epithelia and the keratinocyte of stratified squamous
CC epithelia.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH22806.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; X82693; CAA58014.1; -; mRNA.
DR EMBL; Y12642; CAA73189.1; -; Genomic_DNA.
DR EMBL; AK312164; BAG35098.1; -; mRNA.
DR EMBL; CH471162; EAW82297.1; -; Genomic_DNA.
DR EMBL; CH471162; EAW82298.1; -; Genomic_DNA.
DR EMBL; BC022806; AAH22806.1; ALT_INIT; mRNA.
DR EMBL; BC031330; AAH31330.1; -; mRNA.
DR EMBL; U66837; AAB07524.1; -; Genomic_DNA.
DR CCDS; CCDS6390.1; -.
DR PIR; A57321; A57321.
DR RefSeq; NP_003686.1; NM_003695.2.
DR AlphaFoldDB; Q14210; -.
DR SMR; Q14210; -.
DR BioGRID; 114148; 19.
DR IntAct; Q14210; 8.
DR MINT; Q14210; -.
DR STRING; 9606.ENSP00000301263; -.
DR GlyGen; Q14210; 1 site, 1 O-linked glycan (1 site).
DR PhosphoSitePlus; Q14210; -.
DR BioMuta; LY6D; -.
DR DMDM; 2501524; -.
DR jPOST; Q14210; -.
DR MassIVE; Q14210; -.
DR MaxQB; Q14210; -.
DR PaxDb; Q14210; -.
DR PeptideAtlas; Q14210; -.
DR PRIDE; Q14210; -.
DR ProteomicsDB; 59932; -.
DR ABCD; Q14210; 1 sequenced antibody.
DR Antibodypedia; 14540; 80 antibodies from 17 providers.
DR CPTC; Q14210; 3 antibodies.
DR DNASU; 8581; -.
DR Ensembl; ENST00000301263.5; ENSP00000301263.4; ENSG00000167656.5.
DR GeneID; 8581; -.
DR KEGG; hsa:8581; -.
DR MANE-Select; ENST00000301263.5; ENSP00000301263.4; NM_003695.3; NP_003686.1.
DR UCSC; uc003yxf.2; human.
DR CTD; 8581; -.
DR DisGeNET; 8581; -.
DR GeneCards; LY6D; -.
DR HGNC; HGNC:13348; LY6D.
DR HPA; ENSG00000167656; Tissue enhanced (esophagus, skin, vagina).
DR MIM; 606204; gene.
DR neXtProt; NX_Q14210; -.
DR OpenTargets; ENSG00000167656; -.
DR PharmGKB; PA134928593; -.
DR VEuPathDB; HostDB:ENSG00000167656; -.
DR eggNOG; ENOG502SGKP; Eukaryota.
DR GeneTree; ENSGT00730000111514; -.
DR HOGENOM; CLU_161471_0_0_1; -.
DR InParanoid; Q14210; -.
DR OMA; LRCHVCT; -.
DR OrthoDB; 1544899at2759; -.
DR PhylomeDB; Q14210; -.
DR TreeFam; TF336080; -.
DR PathwayCommons; Q14210; -.
DR Reactome; R-HSA-163125; Post-translational modification: synthesis of GPI-anchored proteins.
DR SignaLink; Q14210; -.
DR BioGRID-ORCS; 8581; 11 hits in 1063 CRISPR screens.
DR ChiTaRS; LY6D; human.
DR GenomeRNAi; 8581; -.
DR Pharos; Q14210; Tbio.
DR PRO; PR:Q14210; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q14210; protein.
DR Bgee; ENSG00000167656; Expressed in lower esophagus mucosa and 116 other tissues.
DR Genevisible; Q14210; HS.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0016020; C:membrane; TAS:ProtInc.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0007155; P:cell adhesion; TAS:ProtInc.
DR GO; GO:0030098; P:lymphocyte differentiation; IBA:GO_Central.
DR GO; GO:0035634; P:response to stilbenoid; IEA:Ensembl.
DR CDD; cd00117; LU; 1.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR018363; CD59_antigen_CS.
DR InterPro; IPR016054; LY6_UPA_recep-like.
DR InterPro; IPR042339; Ly6D.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR PANTHER; PTHR16982; PTHR16982; 1.
DR Pfam; PF00021; UPAR_LY6; 1.
DR SMART; SM00134; LU; 1.
DR SUPFAM; SSF57302; SSF57302; 1.
DR PROSITE; PS00983; LY6_UPAR; 1.
PE 1: Evidence at protein level;
KW Cell adhesion; Cell membrane; Direct protein sequencing; Disulfide bond;
KW Glycoprotein; GPI-anchor; Lipoprotein; Membrane; Reference proteome;
KW Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000269|PubMed:15340161,
FT ECO:0000269|PubMed:7790363"
FT CHAIN 21..98
FT /note="Lymphocyte antigen 6D"
FT /id="PRO_0000036134"
FT PROPEP 99..128
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000036135"
FT DOMAIN 21..108
FT /note="UPAR/Ly6"
FT LIPID 98
FT /note="GPI-anchor amidated asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 23..45
FT /evidence="ECO:0000250"
FT DISULFID 26..32
FT /evidence="ECO:0000250"
FT DISULFID 38..63
FT /evidence="ECO:0000250"
FT DISULFID 67..86
FT /evidence="ECO:0000250"
FT DISULFID 87..92
FT /evidence="ECO:0000250"
FT VARIANT 10
FT /note="A -> T (in dbSNP:rs2572925)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:9366413"
FT /id="VAR_038712"
FT CONFLICT 60
FT /note="K -> E (in Ref. 6; AAB07524)"
FT /evidence="ECO:0000305"
FT CONFLICT 76
FT /note="Q -> L (in Ref. 6; AAB07524)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 128 AA; 13286 MW; 39618DF6AB5B0EBD CRC64;
MRTALLLLAA LAVATGPALT LRCHVCTSSS NCKHSVVCPA SSRFCKTTNT VEPLRGNLVK
KDCAESCTPS YTLQGQVSSG TSSTQCCQED LCNEKLHNAA PTRTALAHSA LSLGLALSLL
AVILAPSL
