LY6D_MOUSE
ID LY6D_MOUSE Reviewed; 127 AA.
AC P35459;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Lymphocyte antigen 6D;
DE Short=Ly-6D;
DE AltName: Full=Thymocyte B-cell antigen;
DE Short=ThB;
DE Flags: Precursor;
GN Name=Ly6d; Synonyms=Ly61, Thb;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J; TISSUE=Thymocyte;
RX PubMed=1401899;
RA Gumley T.P., McKenzie I.F., Kozak C.A., Sandrin M.S.;
RT "Isolation and characterization of cDNA clones for the mouse thymocyte B
RT cell antigen (ThB).";
RL J. Immunol. 149:2615-2618(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=BALB/cJ; TISSUE=Leukocyte;
RX PubMed=7642235; DOI=10.1007/bf00191229;
RA Gumley T.P., McKenzie I.F., Sandrin M.S.;
RT "Sequence and structure of the mouse ThB gene.";
RL Immunogenetics 42:221-224(1995).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Salivary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=19833765; DOI=10.1101/gad.1836009;
RA Inlay M.A., Bhattacharya D., Sahoo D., Serwold T., Seita J., Karsunky H.,
RA Plevritis S.K., Dill D.L., Weissman I.L.;
RT "Ly6d marks the earliest stage of B-cell specification and identifies the
RT branchpoint between B-cell and T-cell development.";
RL Genes Dev. 23:2376-2381(2009).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May act as a specification marker at earliest stage
CC specification of lymphocytes between B- and T-cell development. Marks
CC the earliest stage of B-cell specification.
CC {ECO:0000269|PubMed:19833765}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-
CC anchor {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Lymphoid cells lacking Ly6d, called ALP (all-
CC lymphoid progenitor), retain full lymphoid potential and early thymic
CC seeding activity, whereas cells containing Ly6d, called BLP (B-cell-
CC biased lymphoid progenitor), up-regulate the B-cell specifying factors
CC Ebf1 and Pax5 and behave essentially as B-cell progenitors (at protein
CC level). Thymocytes and B-cells. {ECO:0000269|PubMed:19833765}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA79249.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; X63782; CAA45317.1; -; mRNA.
DR EMBL; L40419; AAA79249.1; ALT_INIT; Genomic_DNA.
DR EMBL; BC025135; AAH25135.1; -; mRNA.
DR CCDS; CCDS27531.1; -.
DR PIR; A46528; A46528.
DR PIR; I54553; I54553.
DR RefSeq; NP_034872.1; NM_010742.1.
DR AlphaFoldDB; P35459; -.
DR SMR; P35459; -.
DR STRING; 10090.ENSMUSP00000047419; -.
DR iPTMnet; P35459; -.
DR PhosphoSitePlus; P35459; -.
DR EPD; P35459; -.
DR MaxQB; P35459; -.
DR PaxDb; P35459; -.
DR PeptideAtlas; P35459; -.
DR PRIDE; P35459; -.
DR ProteomicsDB; 291972; -.
DR Antibodypedia; 14540; 80 antibodies from 17 providers.
DR DNASU; 17068; -.
DR Ensembl; ENSMUST00000040404; ENSMUSP00000047419; ENSMUSG00000034634.
DR GeneID; 17068; -.
DR KEGG; mmu:17068; -.
DR UCSC; uc007wfx.1; mouse.
DR CTD; 8581; -.
DR MGI; MGI:96881; Ly6d.
DR VEuPathDB; HostDB:ENSMUSG00000034634; -.
DR eggNOG; ENOG502SGKP; Eukaryota.
DR GeneTree; ENSGT00730000111514; -.
DR HOGENOM; CLU_161471_0_0_1; -.
DR InParanoid; P35459; -.
DR OMA; LRCHVCT; -.
DR OrthoDB; 1544899at2759; -.
DR PhylomeDB; P35459; -.
DR TreeFam; TF336080; -.
DR Reactome; R-MMU-163125; Post-translational modification: synthesis of GPI-anchored proteins.
DR BioGRID-ORCS; 17068; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Ly6d; mouse.
DR PRO; PR:P35459; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; P35459; protein.
DR Bgee; ENSMUSG00000034634; Expressed in tail skin and 94 other tissues.
DR Genevisible; P35459; MM.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009986; C:cell surface; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0030098; P:lymphocyte differentiation; IEP:UniProtKB.
DR GO; GO:0035634; P:response to stilbenoid; IEP:UniProtKB.
DR CDD; cd00117; LU; 1.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR018363; CD59_antigen_CS.
DR InterPro; IPR016054; LY6_UPA_recep-like.
DR InterPro; IPR042339; Ly6D.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR PANTHER; PTHR16982; PTHR16982; 1.
DR Pfam; PF00021; UPAR_LY6; 1.
DR SMART; SM00134; LU; 1.
DR SUPFAM; SSF57302; SSF57302; 1.
DR PROSITE; PS00983; LY6_UPAR; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein;
KW Membrane; Reference proteome; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..98
FT /note="Lymphocyte antigen 6D"
FT /id="PRO_0000036136"
FT PROPEP 99..127
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000036137"
FT DOMAIN 21..108
FT /note="UPAR/Ly6"
FT LIPID 98
FT /note="GPI-anchor amidated serine"
FT /evidence="ECO:0000255"
FT DISULFID 23..45
FT /evidence="ECO:0000250"
FT DISULFID 26..32
FT /evidence="ECO:0000250"
FT DISULFID 38..63
FT /evidence="ECO:0000250"
FT DISULFID 67..86
FT /evidence="ECO:0000250"
FT DISULFID 87..92
FT /evidence="ECO:0000250"
SQ SEQUENCE 127 AA; 13396 MW; 0AF039B77D105917 CRC64;
MKTALLVLLV LAVATSPAWA LRCHVCTNSA NCKNPQVCPS NFYFCKTVTS VEPLNGNLVR
KECANSCTSD YSQQGHVSSG SEVTQCCQTD LCNERLVSAA PGHALLSSVT LGLATSLSLL
TVMALCL
