ID   LY6E_CHICK              Reviewed;         126 AA.
AC   Q90986;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=Lymphocyte antigen 6E;
DE            Short=Ly-6E;
DE   AltName: Full=Stem cell antigen 2;
DE            Short=SCA-2;
DE   Flags: Precursor;
GN   Name=LY6E; Synonyms=SCA2;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Bone marrow;
RX   PubMed=9349500; DOI=10.1038/sj.onc.1201334;
RA   Petrenko O., Ischenko I., Enrietto P.J.;
RT   "Characterization of changes in gene expression associated with malignant
RT   transformation by the NF-kappaB family member, v-Rel.";
RL   Oncogene 15:1671-1680(1997).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q64253};
CC       Lipid-anchor, GPI-anchor {ECO:0000250|UniProtKB:Q64253}.
CC   -!- TISSUE SPECIFICITY: Expressed by thymic blast cells.
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DR   EMBL; L34554; AAA49063.1; -; mRNA.
DR   RefSeq; NP_990106.1; NM_204775.1.
DR   AlphaFoldDB; Q90986; -.
DR   SMR; Q90986; -.
DR   STRING; 9031.ENSGALP00000025978; -.
DR   PaxDb; Q90986; -.
DR   GeneID; 395550; -.
DR   KEGG; gga:395550; -.
DR   CTD; 4061; -.
DR   VEuPathDB; HostDB:geneid_395550; -.
DR   eggNOG; ENOG502SRPS; Eukaryota.
DR   InParanoid; Q90986; -.
DR   OrthoDB; 1493078at2759; -.
DR   PhylomeDB; Q90986; -.
DR   PRO; PR:Q90986; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0031225; C:anchored component of membrane; IDA:AgBase.
DR   GO; GO:0009986; C:cell surface; IDA:AgBase.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IBA:GO_Central.
DR   GO; GO:0002320; P:lymphoid progenitor cell differentiation; TAS:AgBase.
DR   CDD; cd00117; LU; 1.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR016054; LY6_UPA_recep-like.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   Pfam; PF00021; UPAR_LY6; 1.
DR   SMART; SM00134; LU; 1.
DR   SUPFAM; SSF57302; SSF57302; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein;
KW   Membrane; Reference proteome; Signal.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..?98
FT                   /note="Lymphocyte antigen 6E"
FT                   /id="PRO_0000036142"
FT   PROPEP          ?99..126
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000036143"
FT   DOMAIN          21..98
FT                   /note="UPAR/Ly6"
FT   LIPID           98
FT                   /note="GPI-anchor amidated serine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        96
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        23..48
FT                   /evidence="ECO:0000250"
FT   DISULFID        26..35
FT                   /evidence="ECO:0000250"
FT   DISULFID        41..69
FT                   /evidence="ECO:0000250"
FT   DISULFID        73..89
FT                   /evidence="ECO:0000250"
FT   DISULFID        90..95
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   126 AA;  13011 MW;  EB5C89E6674C73B8 CRC64;
     MKAFLFAVLA AVLCVERAHT LICFSCSDAS SNWACLTPVK CAENEEHCVT TYVGVGIGGK
     SGQSISKGCS PVCPSAGINL GIAAASVYCC DSFLCNISGS SSVKASYAVL ALGILVSFVY
     VLRARE