LY6F_MOUSE
ID LY6F_MOUSE Reviewed; 134 AA.
AC P35460;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Lymphocyte antigen 6F;
DE Short=Ly-6F;
DE AltName: Full=Ly-6F.1;
DE Flags: Precursor;
GN Name=Ly6f;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=BALB/cJ; TISSUE=Liver;
RX PubMed=8515066;
RA Fleming T.J., O'Huigin C., Malek T.R.;
RT "Characterization of two novel Ly-6 genes. Protein sequence and potential
RT structural similarity to alpha-bungarotoxin and other neurotoxins.";
RL J. Immunol. 150:5379-5390(1993).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-
CC anchor {ECO:0000250}.
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DR EMBL; X70922; CAA50270.1; -; Genomic_DNA.
DR EMBL; X70918; CAA50270.1; JOINED; Genomic_DNA.
DR EMBL; X70919; CAA50270.1; JOINED; Genomic_DNA.
DR CCDS; CCDS27543.1; -.
DR PIR; I48639; I48639.
DR RefSeq; NP_032556.1; NM_008530.2.
DR RefSeq; XP_006520585.1; XM_006520522.3.
DR AlphaFoldDB; P35460; -.
DR STRING; 10090.ENSMUSP00000023247; -.
DR PaxDb; P35460; -.
DR PRIDE; P35460; -.
DR DNASU; 17071; -.
DR Ensembl; ENSMUST00000023247; ENSMUSP00000023247; ENSMUSG00000022583.
DR Ensembl; ENSMUST00000189654; ENSMUSP00000140899; ENSMUSG00000022583.
DR GeneID; 17071; -.
DR KEGG; mmu:17071; -.
DR UCSC; uc007wgs.1; mouse.
DR CTD; 17071; -.
DR MGI; MGI:109441; Ly6f.
DR VEuPathDB; HostDB:ENSMUSG00000022583; -.
DR eggNOG; ENOG502TD4F; Eukaryota.
DR GeneTree; ENSGT00940000154560; -.
DR HOGENOM; CLU_106772_0_0_1; -.
DR InParanoid; P35460; -.
DR OMA; DCKVATC; -.
DR OrthoDB; 1592016at2759; -.
DR PhylomeDB; P35460; -.
DR TreeFam; TF337757; -.
DR BioGRID-ORCS; 17071; 1 hit in 72 CRISPR screens.
DR PRO; PR:P35460; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; P35460; protein.
DR Bgee; ENSMUSG00000022583; Expressed in parotid gland and 25 other tissues.
DR Genevisible; P35460; MM.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0033130; F:acetylcholine receptor binding; IBA:GO_Central.
DR GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IBA:GO_Central.
DR GO; GO:0095500; P:acetylcholine receptor signaling pathway; IBA:GO_Central.
DR CDD; cd00117; LU; 1.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR018363; CD59_antigen_CS.
DR InterPro; IPR016054; LY6_UPA_recep-like.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR Pfam; PF00021; UPAR_LY6; 1.
DR SMART; SM00134; LU; 1.
DR SUPFAM; SSF57302; SSF57302; 1.
DR PROSITE; PS00983; LY6_UPAR; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein;
KW Membrane; Reference proteome; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..112
FT /note="Lymphocyte antigen 6F"
FT /id="PRO_0000036144"
FT PROPEP 113..134
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000036145"
FT DOMAIN 27..119
FT /note="UPAR/Ly6"
FT LIPID 112
FT /note="GPI-anchor amidated glycine"
FT /evidence="ECO:0000255"
FT DISULFID 29..53
FT /evidence="ECO:0000250"
FT DISULFID 32..41
FT /evidence="ECO:0000250"
FT DISULFID 46..74
FT /evidence="ECO:0000250"
FT DISULFID 78..98
FT /evidence="ECO:0000250"
FT DISULFID 99..104
FT /evidence="ECO:0000250"
SQ SEQUENCE 134 AA; 14599 MW; 3FF9DD32FA9183CA CRC64;
MDSCHTTKSC VLILLVVLLC AERAQGLECY NCLGVSLGIA CKSITCPYPD AVCISQQVEL
IVDSQRRKVK NKLCFPFCPA NLENMEILGT TVNVNTSCCK EDLCNAPFST GGSTWTMTRV
LLLNLGSVFL QTLL
