LY6G_MOUSE
ID LY6G_MOUSE Reviewed; 134 AA.
AC P35461; A0A087WQF5;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 26-FEB-2020, sequence version 2.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Lymphocyte antigen 6G;
DE Short=Ly-6G;
DE AltName: Full=Ly-6G.1;
DE Flags: Precursor;
GN Name=Ly6g;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000312|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-134, AND TISSUE SPECIFICITY.
RC STRAIN=BALB/cJ; TISSUE=Liver;
RX PubMed=8515066;
RA Fleming T.J., O'Huigin C., Malek T.R.;
RT "Characterization of two novel Ly-6 genes. Protein sequence and potential
RT structural similarity to alpha-bungarotoxin and other neurotoxins.";
RL J. Immunol. 150:5379-5390(1993).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Lipid-anchor, GPI-
CC anchor {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in bone marrow.
CC {ECO:0000269|PubMed:8515066}.
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DR EMBL; AC116498; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; X70920; CAA50269.1; -; Genomic_DNA.
DR EMBL; X70921; CAA50269.1; JOINED; Genomic_DNA.
DR CCDS; CCDS79377.1; -.
DR PIR; I48640; I48640.
DR RefSeq; NP_001297367.1; NM_001310438.1.
DR RefSeq; XP_006521677.1; XM_006521614.1.
DR AlphaFoldDB; P35461; -.
DR STRING; 10090.ENSMUSP00000140173; -.
DR iPTMnet; P35461; -.
DR PhosphoSitePlus; P35461; -.
DR MaxQB; P35461; -.
DR PaxDb; P35461; -.
DR PRIDE; P35461; -.
DR Ensembl; ENSMUST00000190262; ENSMUSP00000140173; ENSMUSG00000022582.
DR GeneID; 546644; -.
DR KEGG; mmu:546644; -.
DR CTD; 546644; -.
DR MGI; MGI:109440; Ly6g.
DR VEuPathDB; HostDB:ENSMUSG00000022582; -.
DR eggNOG; ENOG502TD4F; Eukaryota.
DR GeneTree; ENSGT00940000154560; -.
DR HOGENOM; CLU_106772_0_0_1; -.
DR InParanoid; P35461; -.
DR OMA; VNDANIC; -.
DR OrthoDB; 1592016at2759; -.
DR PhylomeDB; P35461; -.
DR TreeFam; TF337757; -.
DR BioGRID-ORCS; 546644; 0 hits in 34 CRISPR screens.
DR PRO; PR:P35461; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; P35461; protein.
DR Bgee; ENSMUSG00000022582; Expressed in granulocyte and 33 other tissues.
DR ExpressionAtlas; P35461; baseline and differential.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0009897; C:external side of plasma membrane; IDA:MGI.
DR CDD; cd00117; LU; 1.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR018363; CD59_antigen_CS.
DR InterPro; IPR016054; LY6_UPA_recep-like.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR Pfam; PF00021; UPAR_LY6; 1.
DR SMART; SM00134; LU; 1.
DR SUPFAM; SSF57302; SSF57302; 1.
DR PROSITE; PS00983; LY6_UPAR; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein;
KW Membrane; Reference proteome; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..105
FT /note="Lymphocyte antigen 6G"
FT /id="PRO_0000036146"
FT PROPEP 106..134
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000036147"
FT DOMAIN 27..118
FT /note="UPAR/Ly6"
FT /evidence="ECO:0000255"
FT LIPID 105
FT /note="GPI-anchor amidated asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 29..53
FT /evidence="ECO:0000250"
FT DISULFID 32..41
FT /evidence="ECO:0000250"
FT DISULFID 46..74
FT /evidence="ECO:0000250"
FT DISULFID 78..98
FT /evidence="ECO:0000250"
FT DISULFID 99..104
FT /evidence="ECO:0000250"
SQ SEQUENCE 134 AA; 14324 MW; 4D39B74495B86DE0 CRC64;
MDTCHIAKSC VLILLVVLLC AERAQGLECY NCIGVPPETS CNTTTCPFSD GFCVALEIEV
IVDSHRSKVK SNLCLPICPT TLDNTEITGN AVNVKTYCCK EDLCNAAVPT GGSSWTMAGV
LLFSLVSVLL QTFL
