ID   LY6H_BOVIN              Reviewed;         140 AA.
AC   A0JNB3;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Lymphocyte antigen 6H;
DE            Short=Ly-6H;
DE   Flags: Precursor;
GN   Name=LY6H;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Hereford; TISSUE=Fetal brain;
RG   NIH - Mammalian Gene Collection (MGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-
CC       anchor {ECO:0000250}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-6 is the initiator.
CC       {ECO:0000305}.
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DR   EMBL; BC126596; AAI26597.1; -; mRNA.
DR   RefSeq; NP_001073104.1; NM_001079636.2.
DR   AlphaFoldDB; A0JNB3; -.
DR   STRING; 9913.ENSBTAP00000015841; -.
DR   PaxDb; A0JNB3; -.
DR   GeneID; 618749; -.
DR   KEGG; bta:618749; -.
DR   CTD; 4062; -.
DR   eggNOG; ENOG502RVP9; Eukaryota.
DR   InParanoid; A0JNB3; -.
DR   OrthoDB; 1482771at2759; -.
DR   Proteomes; UP000009136; Unplaced.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0045202; C:synapse; IEA:GOC.
DR   GO; GO:0033130; F:acetylcholine receptor binding; IBA:GO_Central.
DR   GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IBA:GO_Central.
DR   GO; GO:0095500; P:acetylcholine receptor signaling pathway; IBA:GO_Central.
DR   CDD; cd00117; LU; 1.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR016054; LY6_UPA_recep-like.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   Pfam; PF00021; UPAR_LY6; 1.
DR   SMART; SM00134; LU; 1.
DR   SUPFAM; SSF57302; SSF57302; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein;
KW   Membrane; Reference proteome; Signal.
FT   SIGNAL          1..25
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..?
FT                   /note="Lymphocyte antigen 6H"
FT                   /id="PRO_0000318199"
FT   PROPEP          ?..140
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000318200"
FT   DOMAIN          26..91
FT                   /note="UPAR/Ly6"
FT   CARBOHYD        36
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        28..52
FT                   /evidence="ECO:0000250"
FT   DISULFID        31..40
FT                   /evidence="ECO:0000250"
FT   DISULFID        45..73
FT                   /evidence="ECO:0000250"
FT   DISULFID        77..104
FT                   /evidence="ECO:0000250"
FT   DISULFID        105..110
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   140 AA;  14813 MW;  148E6CBFD553DFE9 CRC64;
     MLPAAMKGLG LVLLAALLCS SPAHGLWCQD CTLTTNSSHC TPKQCHPSDT VCATVWITDP
     SSSRKDHSVN KMCASSCDFV KRHFFSDYLM GFINSGILKV DVDCCEKDLC NGVAQAGLSP
     WALAGGLLLS LGPALLWAGP