LY6H_MACFA
ID LY6H_MACFA Reviewed; 140 AA.
AC Q4R5M8;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 50.
DE RecName: Full=Lymphocyte antigen 6H;
DE Short=Ly-6H;
DE Flags: Precursor;
GN Name=LY6H; ORFNames=QccE-13216;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain cortex;
RG International consortium for macaque cDNA sequencing and analysis;
RT "DNA sequences of macaque genes expressed in brain or testis and its
RT evolutionary implications.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Believed to act as a modulator of nicotinic acetylcholine
CC receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-
CC containing nAChRs maximum response. May play a role in the
CC intracellular trafficking of alpha-7-containing nAChRs and may inhibit
CC their expression at the cell surface. Seems to inhibit alpha-7/CHRNA7
CC signaling in hippocampal neurons (By similarity).
CC {ECO:0000250|UniProtKB:F1LNW6, ECO:0000250|UniProtKB:Q9WUC3}.
CC -!- SUBUNIT: Interacts with CHRNA4 and CHRNA7.
CC {ECO:0000250|UniProtKB:Q9WUC3}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-
CC anchor {ECO:0000250}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-6 is the initiator.
CC {ECO:0000305}.
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DR EMBL; AB169515; BAE01597.1; -; mRNA.
DR RefSeq; NP_001272213.1; NM_001285284.1.
DR AlphaFoldDB; Q4R5M8; -.
DR STRING; 9541.XP_005564262.1; -.
DR GeneID; 101925361; -.
DR CTD; 4062; -.
DR eggNOG; ENOG502RVP9; Eukaryota.
DR OrthoDB; 1482771at2759; -.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00117; LU; 1.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR016054; LY6_UPA_recep-like.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR Pfam; PF00021; UPAR_LY6; 1.
DR SMART; SM00134; LU; 1.
DR SUPFAM; SSF57302; SSF57302; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein;
KW Membrane; Reference proteome; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..115
FT /note="Lymphocyte antigen 6H"
FT /id="PRO_0000318206"
FT PROPEP 116..140
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000318207"
FT DOMAIN 26..91
FT /note="UPAR/Ly6"
FT LIPID 115
FT /note="GPI-anchor amidated glycine"
FT /evidence="ECO:0000255"
FT CARBOHYD 36
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 28..52
FT /evidence="ECO:0000250|UniProtKB:P0DP57,
FT ECO:0000250|UniProtKB:P0DP58"
FT DISULFID 31..40
FT /evidence="ECO:0000250|UniProtKB:P0DP57,
FT ECO:0000250|UniProtKB:P0DP58"
FT DISULFID 45..73
FT /evidence="ECO:0000250|UniProtKB:P0DP57,
FT ECO:0000250|UniProtKB:P0DP58"
FT DISULFID 77..104
FT /evidence="ECO:0000250|UniProtKB:P0DP57,
FT ECO:0000250|UniProtKB:P0DP58"
SQ SEQUENCE 140 AA; 14757 MW; A9274BFC479A2BA3 CRC64;
MLPAAMKGLG LALLAVLLCS APAHGLWCQD CTLTTNSSHC TPKQCQPSDT VCASVRITDP
SSSRKDHSVN KMCASSCDFV KRHFFSDYLM GFINSGILKV DVDCYEKDLC NGVAGAGHSP
WALAGGLLLS LGPALLWAGP
