LY6H_MOUSE
ID LY6H_MOUSE Reviewed; 139 AA.
AC Q9WUC3;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 2.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Lymphocyte antigen 6H;
DE Short=Ly-6H;
DE Flags: Precursor;
GN Name=Ly6h;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Brain;
RX PubMed=10501842; DOI=10.1007/s002510050583;
RA Apostolopoulos J., Chisholm L.J., Sandrin M.S.;
RT "Identification of mouse Ly6H and its expression in normal tissue.";
RL Immunogenetics 49:987-990(1999).
RN [2]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3]
RP FUNCTION, AND INTERACTION WITH CHRNA4.
RX PubMed=26276394; DOI=10.1074/jbc.m115.647248;
RA Wu M., Puddifoot C.A., Taylor P., Joiner W.J.;
RT "Mechanisms of inhibition and potentiation of alpha4beta2 nicotinic
RT acetylcholine receptors by members of the Ly6 protein family.";
RL J. Biol. Chem. 290:24509-24518(2015).
RN [4]
RP FUNCTION, AND INTERACTION WITH CHRNA7.
RX PubMed=25716842; DOI=10.1523/jneurosci.3630-14.2015;
RA Puddifoot C.A., Wu M., Sung R.J., Joiner W.J.;
RT "Ly6h regulates trafficking of alpha7 nicotinic acetylcholine receptors and
RT nicotine-induced potentiation of glutamatergic signaling.";
RL J. Neurosci. 35:3420-3430(2015).
CC -!- FUNCTION: Believed to act as modulator of nicotinic acetylcholine
CC receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-
CC containing nAChRs maximum response. In vitro inhibits alpha-3:beta-4-
CC containing nAChRs maximum response (PubMed:26276394). May play a role
CC in the intracellular trafficking of alpha-7-containing nAChRs and may
CC inhibit their expression at the cell surface (PubMed:25716842). Seems
CC to inhibit alpha-7/CHRNA7 signaling in hippocampal neurons (By
CC similarity). {ECO:0000250|UniProtKB:F1LNW6,
CC ECO:0000269|PubMed:25716842, ECO:0000269|PubMed:26276394}.
CC -!- SUBUNIT: Interacts with CHRNA4 and CHRNA7.
CC {ECO:0000269|PubMed:25716842, ECO:0000269|PubMed:26276394}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-
CC anchor {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Strongly expressed in brain, also found in lower
CC levels in eye and reproductive tissues.
CC -!- DEVELOPMENTAL STAGE: Expression increases during embryonic development.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-6 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD28600.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AF127091; AAD28600.1; ALT_INIT; mRNA.
DR CCDS; CCDS49640.1; -.
DR RefSeq; NP_001129160.1; NM_001135688.1.
DR RefSeq; NP_001129161.1; NM_001135689.1.
DR RefSeq; NP_035967.1; NM_011837.3.
DR RefSeq; XP_006520962.1; XM_006520899.1.
DR RefSeq; XP_006520963.1; XM_006520900.2.
DR RefSeq; XP_006520964.1; XM_006520901.2.
DR RefSeq; XP_011243908.1; XM_011245606.2.
DR AlphaFoldDB; Q9WUC3; -.
DR BioGRID; 204802; 1.
DR IntAct; Q9WUC3; 1.
DR STRING; 10090.ENSMUSP00000122061; -.
DR GlyGen; Q9WUC3; 1 site.
DR PhosphoSitePlus; Q9WUC3; -.
DR MaxQB; Q9WUC3; -.
DR PaxDb; Q9WUC3; -.
DR PRIDE; Q9WUC3; -.
DR ProteomicsDB; 290198; -.
DR Antibodypedia; 27844; 74 antibodies from 16 providers.
DR DNASU; 23934; -.
DR Ensembl; ENSMUST00000023241; ENSMUSP00000023241; ENSMUSG00000022577.
DR Ensembl; ENSMUST00000065417; ENSMUSP00000070646; ENSMUSG00000022577.
DR Ensembl; ENSMUST00000126129; ENSMUSP00000121951; ENSMUSG00000022577.
DR Ensembl; ENSMUST00000163116; ENSMUSP00000130781; ENSMUSG00000022577.
DR GeneID; 23934; -.
DR KEGG; mmu:23934; -.
DR UCSC; uc011zuk.1; mouse.
DR CTD; 4062; -.
DR MGI; MGI:1346030; Ly6h.
DR VEuPathDB; HostDB:ENSMUSG00000022577; -.
DR eggNOG; ENOG502RVP9; Eukaryota.
DR GeneTree; ENSGT00940000154560; -.
DR HOGENOM; CLU_106772_1_1_1; -.
DR InParanoid; Q9WUC3; -.
DR OMA; DVECCEK; -.
DR OrthoDB; 1482771at2759; -.
DR Reactome; R-MMU-163125; Post-translational modification: synthesis of GPI-anchored proteins.
DR BioGRID-ORCS; 23934; 1 hit in 73 CRISPR screens.
DR PRO; PR:Q9WUC3; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q9WUC3; protein.
DR Bgee; ENSMUSG00000022577; Expressed in subiculum and 159 other tissues.
DR ExpressionAtlas; Q9WUC3; baseline and differential.
DR Genevisible; Q9WUC3; MM.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0033130; F:acetylcholine receptor binding; IDA:MGI.
DR GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IDA:MGI.
DR GO; GO:0095500; P:acetylcholine receptor signaling pathway; IDA:MGI.
DR CDD; cd00117; LU; 1.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR016054; LY6_UPA_recep-like.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR Pfam; PF00021; UPAR_LY6; 1.
DR SMART; SM00134; LU; 1.
DR SUPFAM; SSF57302; SSF57302; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein;
KW Membrane; Reference proteome; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..110
FT /note="Lymphocyte antigen 6H"
FT /id="PRO_0000036150"
FT PROPEP 111..139
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000036151"
FT DOMAIN 26..113
FT /note="UPAR/Ly6"
FT LIPID 110
FT /note="GPI-anchor amidated asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 35
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 28..51
FT /evidence="ECO:0000250|UniProtKB:P0DP57,
FT ECO:0000250|UniProtKB:P0DP58"
FT DISULFID 31..39
FT /evidence="ECO:0000250|UniProtKB:P0DP57,
FT ECO:0000250|UniProtKB:P0DP58"
FT DISULFID 44..72
FT /evidence="ECO:0000250|UniProtKB:P0DP57,
FT ECO:0000250|UniProtKB:P0DP58"
FT DISULFID 76..103
FT /evidence="ECO:0000250|UniProtKB:P0DP57,
FT ECO:0000250|UniProtKB:P0DP58"
FT DISULFID 104..109
FT /evidence="ECO:0000250|UniProtKB:P0DP57,
FT ECO:0000250|UniProtKB:P0DP58"
SQ SEQUENCE 139 AA; 14669 MW; FDEEC13591EF219C CRC64;
MLPAAMKSLG LALLALLLCP SPAHGLWCQD CTLANSSHCA PKQCQPTDTV CASVRITDPS
SSRKDHSVNK MCASSCDFVK RHFFSDYLMG FINSGILKVD VDCCEKDLCN GASVAGRSPW
ALAGGLLLSL GPALLWAGP
