LY6I_MOUSE
ID LY6I_MOUSE Reviewed; 134 AA.
AC Q9WU67; Q05AA4;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Lymphocyte antigen 6I;
DE Short=Ly-6I;
DE AltName: Full=Lymphocyte antigen 6M;
DE Short=Ly-6M;
DE Flags: Precursor;
GN Name=Ly6i; Synonyms=Ly6m;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND VARIANTS GLU-6 AND ARG-68.
RC STRAIN=BALB/cJ, C57BL/6J, and NOD;
RC TISSUE=Bone marrow, Keratinocyte, and Plasmacytoma;
RX PubMed=10861067; DOI=10.4049/jimmunol.165.1.313;
RA Pflugh D.L., Maher S.E., Bothwell A.L.M.;
RT "Ly-6I, a new member of the murine Ly-6 superfamily with a distinct pattern
RT of expression.";
RL J. Immunol. 165:313-321(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/Ola; TISSUE=Splenocyte;
RX PubMed=10807778;
RA Patterson J.M.M., Johnson M.H., Zimonjic D.B., Graubert T.A.;
RT "Characterization of Ly-6M, a novel member of the Ly-6 family of
RT hematopoietic proteins.";
RL Blood 95:3125-3132(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Lipid-anchor, GPI-
CC anchor {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Expressed in hematopoietic tissue (spleen, thymus,
CC bone marrow). Also found in peritoneal macrophages, peripheral blood
CC leukocytes, liver, heart, brain, kidney and lung.
CC -!- POLYMORPHISM: Ly-6I.2 and Ly-6I.1 are expressed in bone marrow of
CC strain C57BL/6 and strain NOD, respectively.
CC {ECO:0000269|PubMed:10861067}.
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DR EMBL; AF231406; AAF79938.1; -; Genomic_DNA.
DR EMBL; AF232024; AAF79939.1; -; mRNA.
DR EMBL; AF118557; AAD34344.1; -; Genomic_DNA.
DR EMBL; BC125350; AAI25351.1; -; mRNA.
DR EMBL; BC132052; AAI32053.1; -; mRNA.
DR CCDS; CCDS27539.1; -.
DR RefSeq; NP_065244.2; NM_020498.2.
DR RefSeq; XP_006521275.1; XM_006521212.3.
DR RefSeq; XP_006521276.1; XM_006521213.3.
DR AlphaFoldDB; Q9WU67; -.
DR STRING; 10090.ENSMUSP00000023250; -.
DR GlyGen; Q9WU67; 1 site.
DR PaxDb; Q9WU67; -.
DR PRIDE; Q9WU67; -.
DR ProteomicsDB; 292060; -.
DR DNASU; 57248; -.
DR Ensembl; ENSMUST00000023250; ENSMUSP00000023250; ENSMUSG00000022586.
DR Ensembl; ENSMUST00000166694; ENSMUSP00000129867; ENSMUSG00000022586.
DR GeneID; 57248; -.
DR KEGG; mmu:57248; -.
DR UCSC; uc007wgj.2; mouse.
DR CTD; 57248; -.
DR MGI; MGI:1888480; Ly6i.
DR VEuPathDB; HostDB:ENSMUSG00000022586; -.
DR eggNOG; ENOG502TD4F; Eukaryota.
DR GeneTree; ENSGT00940000154560; -.
DR HOGENOM; CLU_106772_0_0_1; -.
DR InParanoid; Q9WU67; -.
DR OrthoDB; 1592016at2759; -.
DR PhylomeDB; Q9WU67; -.
DR TreeFam; TF337757; -.
DR BioGRID-ORCS; 57248; 1 hit in 69 CRISPR screens.
DR PRO; PR:Q9WU67; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q9WU67; protein.
DR Bgee; ENSMUSG00000022586; Expressed in granulocyte and 29 other tissues.
DR Genevisible; Q9WU67; MM.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IEA:GOC.
DR GO; GO:0033130; F:acetylcholine receptor binding; IBA:GO_Central.
DR GO; GO:0030550; F:acetylcholine receptor inhibitor activity; IBA:GO_Central.
DR GO; GO:0095500; P:acetylcholine receptor signaling pathway; IBA:GO_Central.
DR CDD; cd00117; LU; 1.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR018363; CD59_antigen_CS.
DR InterPro; IPR016054; LY6_UPA_recep-like.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR Pfam; PF00021; UPAR_LY6; 1.
DR SMART; SM00134; LU; 1.
DR SUPFAM; SSF57302; SSF57302; 1.
DR PROSITE; PS00983; LY6_UPAR; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein;
KW Membrane; Reference proteome; Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..112
FT /note="Lymphocyte antigen 6I"
FT /id="PRO_0000036152"
FT PROPEP 113..134
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000036153"
FT DOMAIN 27..105
FT /note="UPAR/Ly6"
FT LIPID 112
FT /note="GPI-anchor amidated glycine"
FT /evidence="ECO:0000255"
FT CARBOHYD 95
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 29..53
FT /evidence="ECO:0000250"
FT DISULFID 32..41
FT /evidence="ECO:0000250"
FT DISULFID 46..74
FT /evidence="ECO:0000250"
FT DISULFID 78..98
FT /evidence="ECO:0000250"
FT DISULFID 99..104
FT /evidence="ECO:0000250"
FT VARIANT 6
FT /note="A -> E (in Ly-6I.1)"
FT /evidence="ECO:0000269|PubMed:10861067"
FT VARIANT 68
FT /note="K -> R (in Ly-6I.1)"
FT /evidence="ECO:0000269|PubMed:10861067"
SQ SEQUENCE 134 AA; 14714 MW; F9CB5A84A1C192AE CRC64;
MDTSHAIKSC VLILLVTLLC AERAQGLECY QCYGVPFETS CPSFTCPYPD GFCVAQEEEF
IANSQRKKVK SRSCHPFCPD EIEKKFILDP NTKMNISCCQ EDLCNAAVPT GGSSWTTAGV
LLFSLGSVLL QTLM
