ID   LY6L_HUMAN              Reviewed;         138 AA.
AC   H3BQJ8;
DT   02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2012, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Lymphocyte antigen 6L {ECO:0000305};
DE   AltName: Full=Lymphocyte antigen 6 complex locus protein L {ECO:0000312|HGNC:HGNC:52284};
DE   Flags: Precursor;
GN   Name=LY6L {ECO:0000312|HGNC:HGNC:52284};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16421571; DOI=10.1038/nature04406;
RA   Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA   Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA   Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA   Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA   Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA   Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA   Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA   Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA   Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA   O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA   Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA   Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA   Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA   Platzer M., Shimizu N., Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 8.";
RL   Nature 439:331-335(2006).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Lipid-anchor, GPI-
CC       anchor {ECO:0000255}.
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DR   EMBL; AC083982; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC236721; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_016869619.1; XM_017014130.1.
DR   RefSeq; XP_016885686.1; XM_017030197.1.
DR   RefSeq; XP_016885962.1; XM_017030473.1.
DR   AlphaFoldDB; H3BQJ8; -.
DR   STRING; 9606.ENSP00000455811; -.
DR   GlyGen; H3BQJ8; 1 site.
DR   BioMuta; LY6L; -.
DR   MassIVE; H3BQJ8; -.
DR   PaxDb; H3BQJ8; -.
DR   PeptideAtlas; H3BQJ8; -.
DR   PRIDE; H3BQJ8; -.
DR   Ensembl; ENST00000562505.2; ENSP00000455811.1; ENSG00000261667.2.
DR   Ensembl; ENST00000631950.1; ENSP00000487842.1; ENSG00000282693.1.
DR   MANE-Select; ENST00000562505.2; ENSP00000455811.1; NM_001368160.2; NP_001355089.1.
DR   UCSC; uc064qwu.1; human.
DR   GeneCards; LY6L; -.
DR   HGNC; HGNC:52284; LY6L.
DR   HPA; ENSG00000261667; Tissue enhanced (brain, kidney).
DR   neXtProt; NX_H3BQJ8; -.
DR   VEuPathDB; HostDB:ENSG00000261667; -.
DR   eggNOG; ENOG502TM7T; Eukaryota.
DR   GeneTree; ENSGT00940000154560; -.
DR   HOGENOM; CLU_106772_1_0_1; -.
DR   InParanoid; H3BQJ8; -.
DR   OMA; TECPPTW; -.
DR   OrthoDB; 1592016at2759; -.
DR   PhylomeDB; H3BQJ8; -.
DR   BioGRID-ORCS; 101928108; 0 hits in 11 CRISPR screens.
DR   Pharos; H3BQJ8; Tdark.
DR   PRO; PR:H3BQJ8; -.
DR   Proteomes; UP000005640; Chromosome 8.
DR   RNAct; H3BQJ8; protein.
DR   Bgee; ENSG00000261667; Expressed in adult mammalian kidney and 11 other tissues.
DR   GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   Gene3D; 2.10.60.10; -; 1.
DR   InterPro; IPR016054; LY6_UPA_recep-like.
DR   InterPro; IPR045860; Snake_toxin-like_sf.
DR   Pfam; PF00021; UPAR_LY6; 1.
DR   SMART; SM00134; LU; 1.
DR   SUPFAM; SSF57302; SSF57302; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein;
KW   Membrane; Reference proteome; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..117
FT                   /note="Lymphocyte antigen 6L"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_5008163148"
FT   PROPEP          118..138
FT                   /note="Removed in mature form"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000438094"
FT   DOMAIN          28..122
FT                   /note="UPAR/Ly6"
FT                   /evidence="ECO:0000255"
FT   LIPID           117
FT                   /note="GPI-anchor amidated glycine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        27
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        30..47
FT                   /evidence="ECO:0000250|UniProtKB:Q03405"
FT   DISULFID        103..108
FT                   /evidence="ECO:0000250|UniProtKB:Q03405"
SQ   SEQUENCE   138 AA;  15317 MW;  6CFCA3A34C01248C CRC64;
     MERLVLTLCT LPLAVASAGC ATTPARNLSC YQCFKVSSWT ECPPTWCSPL DQVCISNEVV
     VSFKWSVRVL LSKRCAPRCP NDNMKFEWSP APMVQGVITR RCCSWALCNR ALTPQEGRWA
     LRGGLLLQVG LSLLRALL