LY6L_MOUSE
ID LY6L_MOUSE Reviewed; 140 AA.
AC H3BJG9;
DT 02-NOV-2016, integrated into UniProtKB/Swiss-Prot.
DT 18-APR-2012, sequence version 1.
DT 03-AUG-2022, entry version 55.
DE RecName: Full=Lymphocyte antigen 6L;
DE AltName: Full=Lymphocyte antigen 6 complex locus protein L;
DE Flags: Precursor;
GN Name=Ly6l {ECO:0000312|MGI:MGI:5313101};
GN Synonyms=Gm20654 {ECO:0000312|MGI:MGI:5313101};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255}; Lipid-anchor, GPI-
CC anchor {ECO:0000255}.
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DR EMBL; AC121359; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS84172.1; -.
DR RefSeq; NP_001333978.1; NM_001347049.1.
DR AlphaFoldDB; H3BJG9; -.
DR STRING; 10090.ENSMUSP00000134982; -.
DR PaxDb; H3BJG9; -.
DR PRIDE; H3BJG9; -.
DR ProteomicsDB; 291974; -.
DR Ensembl; ENSMUST00000177479; ENSMUSP00000134982; ENSMUSG00000093626.
DR GeneID; 102637705; -.
DR KEGG; mmu:102637705; -.
DR CTD; 101928108; -.
DR MGI; MGI:5313101; Ly6l.
DR VEuPathDB; HostDB:ENSMUSG00000093626; -.
DR eggNOG; ENOG502TM7T; Eukaryota.
DR GeneTree; ENSGT00940000154560; -.
DR HOGENOM; CLU_106772_1_0_1; -.
DR InParanoid; H3BJG9; -.
DR OMA; TECPPTW; -.
DR OrthoDB; 1592016at2759; -.
DR PhylomeDB; H3BJG9; -.
DR BioGRID-ORCS; 102637705; 0 hits in 34 CRISPR screens.
DR ChiTaRS; Ly6l; mouse.
DR PRO; PR:H3BJG9; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; H3BJG9; protein.
DR Bgee; ENSMUSG00000093626; Expressed in proximal tubule and 1 other tissue.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR CDD; cd00117; LU; 1.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR016054; LY6_UPA_recep-like.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR Pfam; PF00021; UPAR_LY6; 1.
DR SMART; SM00134; LU; 1.
DR SUPFAM; SSF57302; SSF57302; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; Glycoprotein; GPI-anchor; Lipoprotein;
KW Membrane; Reference proteome; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT CHAIN 21..116
FT /note="Lymphocyte antigen 6L"
FT /evidence="ECO:0000255"
FT /id="PRO_5003580898"
FT PROPEP 117..140
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000438095"
FT DOMAIN 31..124
FT /note="UPAR/Ly6"
FT /evidence="ECO:0000255"
FT LIPID 116
FT /note="GPI-anchor amidated serine"
FT /evidence="ECO:0000255"
FT DISULFID 33..50
FT /evidence="ECO:0000250|UniProtKB:Q03405"
FT DISULFID 105..110
FT /evidence="ECO:0000250|UniProtKB:Q03405"
SQ SEQUENCE 140 AA; 15540 MW; 9FF312B3EB40866C CRC64;
MAPLLLVLWA SLVSMELTGG MMVNEVPAQN LSCFECFKVL QASKCHPIEC RPNEKVCVSN
EVLLYTSTKR RTQISKRCAT ACPNSNNVIE WSLGNTQARI TRRCCSGDRC NRAPGSWEGF
WSLPGRLLLP MGLGLFCTLL
