ID   LYC1_YARLI              Reviewed;         392 AA.
AC   P41929; Q6C6X3;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 2.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Lysine acetyltransferase;
DE            Short=LAT;
DE            EC=2.3.1.32;
DE   AltName: Full=Lysine N(6)-acetyltransferase;
GN   Name=LYC1; OrderedLocusNames=YALI0E05533g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=ATCC 20460 / W29 / CBS 7504 / IFP29;
RX   PubMed=8082161; DOI=10.1007/bf00712962;
RA   Beckerich J.-M., Lambert M., Gaillardin C.;
RT   "LYC1 is the structural gene for lysine N-6-acetyl transferase in yeast.";
RL   Curr. Genet. 25:24-29(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=acetyl phosphate + L-lysine = H(+) + N(6)-acetyl-L-lysine +
CC         phosphate; Xref=Rhea:RHEA:14417, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:22191, ChEBI:CHEBI:32551, ChEBI:CHEBI:43474,
CC         ChEBI:CHEBI:58260; EC=2.3.1.32;
CC   -!- PATHWAY: Amino-acid degradation; L-lysine degradation via acetylation
CC       pathway; glutarate from L-lysine: step 1/6.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA45112.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; X63548; CAA45112.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; CR382131; CAG79170.1; -; Genomic_DNA.
DR   PIR; S39816; S39816.
DR   RefSeq; XP_503589.1; XM_503589.1.
DR   AlphaFoldDB; P41929; -.
DR   EnsemblFungi; CAG79170; CAG79170; YALI0_E05533g.
DR   GeneID; 2911519; -.
DR   KEGG; yli:YALI0E05533g; -.
DR   VEuPathDB; FungiDB:YALI0_E05533g; -.
DR   HOGENOM; CLU_038171_2_0_1; -.
DR   InParanoid; P41929; -.
DR   OMA; YRRQGMA; -.
DR   BioCyc; MetaCyc:MON-8145; -.
DR   UniPathway; UPA00869; UER00841.
DR   Proteomes; UP000001300; Chromosome E.
DR   GO; GO:0004468; F:lysine N-acetyltransferase activity, acting on acetyl phosphate as donor; IEA:UniProtKB-EC.
DR   GO; GO:0019473; P:L-lysine catabolic process to glutarate, by acetylation; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR016181; Acyl_CoA_acyltransferase.
DR   SUPFAM; SSF55729; SSF55729; 1.
PE   4: Predicted;
KW   Acyltransferase; Reference proteome; Transferase.
FT   CHAIN           1..392
FT                   /note="Lysine acetyltransferase"
FT                   /id="PRO_0000084531"
FT   CONFLICT        275
FT                   /note="I -> Y (in Ref. 1; CAA45112)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   392 AA;  43935 MW;  8B9D2C6A972A907D CRC64;
     MSLREITSPD EIRDTRSFSH LEWGAFLSID DYNHREEIVL GHTPMCKNRL KSWGLYIEDG
     TRVAACETLE RPALVQCKDG KIKSTSTFSI GAVFTPKEHR GKGYASVMMK QMASGIPFKP
     TLTDADIIKA TGVSDVDQTL RVTPLWSDVG TFYEKFGWIG TTDLQYVFEV DGSASQNGVN
     GTPNGTNGTN GVNGHTNGTN GHSSAVKYLS EEDVYRLADV EASSFASDFE KFPFKGSYKC
     GIVPDRTVYE WHLARAKFLA KFAKVPEPKV FGAQIGDSWM AWHHMYNARE LVILRAKLAK
     AEDLVELIAA AKNHLCKDGF SDQINKIILW EQEREWNHIV DGLSYDAIDQ AIEKSQGKRE
     HRGSSIPAVM FVEYKLQKDA MEFVDHGKLT WC