LYG1_HUMAN
ID LYG1_HUMAN Reviewed; 194 AA.
AC Q8N1E2; Q53RV9;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Lysozyme g-like protein 1;
DE EC=3.2.1.-;
DE Flags: Precursor;
GN Name=LYG1; ORFNames=UNQ1939/PRO4422;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=12574869; DOI=10.1007/s00239-002-2396-z;
RA Irwin D.M., Gong Z.;
RT "Molecular evolution of vertebrate goose-type lysozyme genes.";
RL J. Mol. Evol. 56:234-242(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon, and Kidney;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q8N1E2; P42858: HTT; NbExp=3; IntAct=EBI-13309213, EBI-466029;
CC Q8N1E2; Q7Z7N9: TMEM179B; NbExp=3; IntAct=EBI-13309213, EBI-11724423;
CC Q8N1E2; O95231: VENTX; NbExp=3; IntAct=EBI-13309213, EBI-10191303;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 23 family. {ECO:0000305}.
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DR EMBL; AY358988; AAQ89347.1; -; mRNA.
DR EMBL; AC079447; AAX93256.1; -; Genomic_DNA.
DR EMBL; CH471127; EAX01872.1; -; Genomic_DNA.
DR EMBL; BC029126; AAH29126.1; -; mRNA.
DR CCDS; CCDS2043.1; -.
DR RefSeq; NP_777558.1; NM_174898.2.
DR RefSeq; XP_005263926.1; XM_005263869.2.
DR RefSeq; XP_005263927.1; XM_005263870.3.
DR RefSeq; XP_005263928.1; XM_005263871.4.
DR RefSeq; XP_011508882.1; XM_011510580.2.
DR RefSeq; XP_016858800.1; XM_017003311.1.
DR RefSeq; XP_016858801.1; XM_017003312.1.
DR RefSeq; XP_016858802.1; XM_017003313.1.
DR AlphaFoldDB; Q8N1E2; -.
DR SMR; Q8N1E2; -.
DR BioGRID; 126196; 4.
DR IntAct; Q8N1E2; 4.
DR STRING; 9606.ENSP00000386923; -.
DR CAZy; GH23; Glycoside Hydrolase Family 23.
DR iPTMnet; Q8N1E2; -.
DR PhosphoSitePlus; Q8N1E2; -.
DR BioMuta; LYG1; -.
DR DMDM; 47117245; -.
DR jPOST; Q8N1E2; -.
DR PaxDb; Q8N1E2; -.
DR PeptideAtlas; Q8N1E2; -.
DR PRIDE; Q8N1E2; -.
DR Antibodypedia; 32811; 39 antibodies from 11 providers.
DR DNASU; 129530; -.
DR Ensembl; ENST00000308528.9; ENSP00000311320.4; ENSG00000144214.10.
DR Ensembl; ENST00000409448.1; ENSP00000386923.1; ENSG00000144214.10.
DR GeneID; 129530; -.
DR KEGG; hsa:129530; -.
DR MANE-Select; ENST00000308528.9; ENSP00000311320.4; NM_174898.3; NP_777558.1.
DR UCSC; uc002szy.3; human.
DR CTD; 129530; -.
DR DisGeNET; 129530; -.
DR GeneCards; LYG1; -.
DR HGNC; HGNC:27014; LYG1.
DR HPA; ENSG00000144214; Tissue enhanced (kidney).
DR neXtProt; NX_Q8N1E2; -.
DR PharmGKB; PA162394698; -.
DR VEuPathDB; HostDB:ENSG00000144214; -.
DR eggNOG; ENOG502RZXI; Eukaryota.
DR GeneTree; ENSGT00390000017614; -.
DR HOGENOM; CLU_089081_1_0_1; -.
DR InParanoid; Q8N1E2; -.
DR OMA; ARARYYK; -.
DR OrthoDB; 1255725at2759; -.
DR PhylomeDB; Q8N1E2; -.
DR TreeFam; TF329826; -.
DR PathwayCommons; Q8N1E2; -.
DR SignaLink; Q8N1E2; -.
DR BioGRID-ORCS; 129530; 10 hits in 1069 CRISPR screens.
DR ChiTaRS; LYG1; human.
DR GenomeRNAi; 129530; -.
DR Pharos; Q8N1E2; Tdark.
DR PRO; PR:Q8N1E2; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q8N1E2; protein.
DR Bgee; ENSG00000144214; Expressed in kidney epithelium and 104 other tissues.
DR Genevisible; Q8N1E2; HS.
DR GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR GO; GO:0003796; F:lysozyme activity; IBA:GO_Central.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR GO; GO:0009253; P:peptidoglycan catabolic process; IEA:InterPro.
DR InterPro; IPR002152; Glyco_hydro_23.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR PIRSF; PIRSF001065; Lysozyme_g; 1.
DR PRINTS; PR00749; LYSOZYMEG.
DR SUPFAM; SSF53955; SSF53955; 1.
PE 1: Evidence at protein level;
KW Disulfide bond; Glycosidase; Hydrolase; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..194
FT /note="Lysozyme g-like protein 1"
FT /id="PRO_0000012023"
FT DISULFID 24..80
FT /evidence="ECO:0000250"
FT DISULFID 38..49
FT /evidence="ECO:0000250"
SQ SEQUENCE 194 AA; 21431 MW; 42B0FC864AEF8C20 CRC64;
MSALWLLLGL LALMDLSESS NWGCYGNIQS LDTPGASCGI GRRHGLNYCG VRASERLAEI
DMPYLLKYQP MMQTIGQKYC MDPAVIAGVL SRKSPGDKIL VNMGDRTSMV QDPGSQAPTS
WISESQVSQT TEVLTTRIKE IQRRFPTWTP DQYLRGGLCA YSGGAGYVRS SQDLSCDFCN
DVLARAKYLK RHGF
