LYG1_MOUSE
ID LYG1_MOUSE Reviewed; 197 AA.
AC Q9D7Q0;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Lysozyme g-like protein 1;
DE EC=3.2.1.-;
DE Flags: Precursor;
GN Name=Lyg1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 23 family. {ECO:0000305}.
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DR EMBL; AK009014; BAB26026.1; -; mRNA.
DR CCDS; CCDS35543.1; -.
DR RefSeq; NP_081387.1; NM_027111.3.
DR AlphaFoldDB; Q9D7Q0; -.
DR SMR; Q9D7Q0; -.
DR STRING; 10090.ENSMUSP00000027254; -.
DR CAZy; GH23; Glycoside Hydrolase Family 23.
DR PhosphoSitePlus; Q9D7Q0; -.
DR PaxDb; Q9D7Q0; -.
DR PRIDE; Q9D7Q0; -.
DR ProteomicsDB; 291977; -.
DR Antibodypedia; 32811; 39 antibodies from 11 providers.
DR Ensembl; ENSMUST00000114894; ENSMUSP00000110544; ENSMUSG00000026085.
DR GeneID; 69541; -.
DR KEGG; mmu:69541; -.
DR UCSC; uc007asl.1; mouse.
DR CTD; 129530; -.
DR MGI; MGI:1916791; Lyg1.
DR VEuPathDB; HostDB:ENSMUSG00000026085; -.
DR eggNOG; ENOG502RZXI; Eukaryota.
DR GeneTree; ENSGT00390000017614; -.
DR HOGENOM; CLU_089081_1_0_1; -.
DR InParanoid; Q9D7Q0; -.
DR OMA; ARARYYK; -.
DR OrthoDB; 1255725at2759; -.
DR BioGRID-ORCS; 69541; 1 hit in 74 CRISPR screens.
DR PRO; PR:Q9D7Q0; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q9D7Q0; protein.
DR Bgee; ENSMUSG00000026085; Expressed in tongue and 6 other tissues.
DR ExpressionAtlas; Q9D7Q0; baseline and differential.
DR Genevisible; Q9D7Q0; MM.
DR GO; GO:0005576; C:extracellular region; IBA:GO_Central.
DR GO; GO:0003796; F:lysozyme activity; IBA:GO_Central.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IBA:GO_Central.
DR GO; GO:0009253; P:peptidoglycan catabolic process; IEA:InterPro.
DR InterPro; IPR002152; Glyco_hydro_23.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR PIRSF; PIRSF001065; Lysozyme_g; 1.
DR PRINTS; PR00749; LYSOZYMEG.
DR SUPFAM; SSF53955; SSF53955; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycosidase; Hydrolase; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..197
FT /note="Lysozyme g-like protein 1"
FT /id="PRO_0000012024"
FT ACT_SITE 93
FT /evidence="ECO:0000250"
FT DISULFID 24..80
FT /evidence="ECO:0000250"
FT DISULFID 38..49
FT /evidence="ECO:0000250"
SQ SEQUENCE 197 AA; 21870 MW; F64A5C4495F86F79 CRC64;
MSPLWLLLGL LALTGSSESS SWGCYGNIRT LDTPGASCRI GRRYGLTYCG VRASERLAEV
DRPYLLRHQP TMRLVGQKYC MDPAVIAGVL SRESPGGNYV VDLGNIGSGL GMVKETKFYP
PTAWKSETWV SQKTQTLTSS IKEIKTRFPT WTADQHLRGG LCAYSKGPNF VRSNQDLNCD
FCNDVLARAK YFKDHGF
