LYG2_HUMAN
ID LYG2_HUMAN Reviewed; 212 AA.
AC Q86SG7; Q496G2; Q53RW0;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2004, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Lysozyme g-like protein 2;
DE EC=3.2.1.-;
DE Flags: Precursor;
GN Name=LYG2; Synonyms=LYGH;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=12574869; DOI=10.1007/s00239-002-2396-z;
RA Irwin D.M., Gong Z.;
RT "Molecular evolution of vertebrate goose-type lysozyme genes.";
RL J. Mol. Evol. 56:234-242(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-182 (ISOFORM 1).
RA Yu L.;
RL Submitted (JAN-2001) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP TISSUE SPECIFICITY, IDENTIFICATION BY MASS SPECTROMETRY, AND FUNCTION.
RX PubMed=21093056; DOI=10.1016/j.molimm.2010.10.008;
RA Huang P., Li W.S., Xie J., Yang X.M., Jiang D.K., Jiang S., Yu L.;
RT "Characterization and expression of HLysG2, a basic goose-type lysozyme
RT from the human eye and testis.";
RL Mol. Immunol. 48:524-531(2011).
CC -!- FUNCTION: May act as a potent antibacterial protein that may play a
CC role in the innate immunity. {ECO:0000269|PubMed:21093056}.
CC -!- INTERACTION:
CC Q86SG7; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-18312334, EBI-11139477;
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q86SG7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86SG7-2; Sequence=VSP_056329;
CC -!- TISSUE SPECIFICITY: Strong expression detected in the eye and weak
CC expression in the testis. No expression is observed in any other
CC tissues. {ECO:0000269|PubMed:21093056}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 23 family. {ECO:0000305}.
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DR EMBL; AY026238; AAK16605.1; -; mRNA.
DR EMBL; AC079447; AAX93255.1; -; Genomic_DNA.
DR EMBL; BC100882; AAI00883.1; -; mRNA.
DR EMBL; BC100883; AAI00884.1; -; mRNA.
DR EMBL; BC100884; AAI00885.1; -; mRNA.
DR EMBL; BC100885; AAI00886.1; -; mRNA.
DR EMBL; AF323919; AAO32945.1; -; mRNA.
DR CCDS; CCDS2042.1; -. [Q86SG7-1]
DR RefSeq; NP_783862.2; NM_175735.3. [Q86SG7-1]
DR RefSeq; XP_016859240.1; XM_017003751.1. [Q86SG7-1]
DR AlphaFoldDB; Q86SG7; -.
DR SMR; Q86SG7; -.
DR BioGRID; 129047; 85.
DR IntAct; Q86SG7; 29.
DR STRING; 9606.ENSP00000327533; -.
DR CAZy; GH23; Glycoside Hydrolase Family 23.
DR iPTMnet; Q86SG7; -.
DR PhosphoSitePlus; Q86SG7; -.
DR BioMuta; LYG2; -.
DR DMDM; 47117209; -.
DR MassIVE; Q86SG7; -.
DR PaxDb; Q86SG7; -.
DR PeptideAtlas; Q86SG7; -.
DR PRIDE; Q86SG7; -.
DR ProteomicsDB; 61990; -.
DR ProteomicsDB; 69589; -. [Q86SG7-1]
DR Antibodypedia; 32804; 66 antibodies from 15 providers.
DR DNASU; 254773; -.
DR Ensembl; ENST00000333017.7; ENSP00000327533.2; ENSG00000185674.10. [Q86SG7-1]
DR Ensembl; ENST00000409238.5; ENSP00000386939.1; ENSG00000185674.10. [Q86SG7-1]
DR Ensembl; ENST00000423800.5; ENSP00000390357.1; ENSG00000185674.10. [Q86SG7-2]
DR GeneID; 254773; -.
DR KEGG; hsa:254773; -.
DR MANE-Select; ENST00000333017.7; ENSP00000327533.2; NM_175735.4; NP_783862.2.
DR UCSC; uc002szw.2; human. [Q86SG7-1]
DR CTD; 254773; -.
DR DisGeNET; 254773; -.
DR GeneCards; LYG2; -.
DR HGNC; HGNC:29615; LYG2.
DR HPA; ENSG00000185674; Group enriched (brain, retina, skin, testis).
DR MIM; 616547; gene.
DR neXtProt; NX_Q86SG7; -.
DR OpenTargets; ENSG00000185674; -.
DR PharmGKB; PA162394717; -.
DR VEuPathDB; HostDB:ENSG00000185674; -.
DR eggNOG; ENOG502RZXI; Eukaryota.
DR GeneTree; ENSGT00390000017614; -.
DR InParanoid; Q86SG7; -.
DR OMA; HPTGAWD; -.
DR OrthoDB; 1255725at2759; -.
DR PhylomeDB; Q86SG7; -.
DR TreeFam; TF329826; -.
DR BRENDA; 3.2.1.17; 2681.
DR PathwayCommons; Q86SG7; -.
DR SignaLink; Q86SG7; -.
DR BioGRID-ORCS; 254773; 5 hits in 1067 CRISPR screens.
DR GenomeRNAi; 254773; -.
DR Pharos; Q86SG7; Tbio.
DR PRO; PR:Q86SG7; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q86SG7; protein.
DR Bgee; ENSG00000185674; Expressed in buccal mucosa cell and 107 other tissues.
DR ExpressionAtlas; Q86SG7; baseline and differential.
DR Genevisible; Q86SG7; HS.
DR GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR GO; GO:0003796; F:lysozyme activity; IDA:UniProtKB.
DR GO; GO:0042742; P:defense response to bacterium; IDA:UniProtKB.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
DR GO; GO:0009253; P:peptidoglycan catabolic process; IEA:InterPro.
DR InterPro; IPR002152; Glyco_hydro_23.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR PIRSF; PIRSF001065; Lysozyme_g; 1.
DR PRINTS; PR00749; LYSOZYMEG.
DR SUPFAM; SSF53955; SSF53955; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Disulfide bond; Glycosidase; Hydrolase;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..212
FT /note="Lysozyme g-like protein 2"
FT /id="PRO_0000012025"
FT ACT_SITE 105
FT /evidence="ECO:0000250"
FT DISULFID 39..92
FT /evidence="ECO:0000250"
FT DISULFID 53..61
FT /evidence="ECO:0000250"
FT VAR_SEQ 175..212
FT /note="GLSAFKSGIEAIATPSDIDNDFVNDIIARAKFYKRQSF -> FFLL (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_056329"
FT CONFLICT 8
FT /note="W -> G (in Ref. 4; AAK16605/AAO32945)"
FT /evidence="ECO:0000305"
FT CONFLICT 19
FT /note="G -> S (in Ref. 4; AAK16605/AAO32945)"
FT /evidence="ECO:0000305"
FT CONFLICT 55
FT /note="A -> P (in Ref. 4; AAK16605/AAO32945)"
FT /evidence="ECO:0000305"
FT CONFLICT 175..182
FT /note="GLSAFKSG -> RLYSEYFY (in Ref. 4)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 212 AA; 23498 MW; F1D36C905373D625 CRC64;
MLSSVVFWGL IALIGTSRGS YPFSHSMKPH LHPRLYHGCY GDIMTMKTSG ATCDANSVMN
CGIRGSEMFA EMDLRAIKPY QTLIKEVGQR HCVDPAVIAA IISRESHGGS VLQDGWDHRG
LKFGLMQLDK QTYHPVGAWD SKEHLSQATG ILTERIKAIQ KKFPTWSVAQ HLKGGLSAFK
SGIEAIATPS DIDNDFVNDI IARAKFYKRQ SF
