LYG2_MOUSE
ID LYG2_MOUSE Reviewed; 213 AA.
AC Q3V1I0; B9EJU6;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Lysozyme g-like protein 2;
DE EC=3.2.1.-;
DE Flags: Precursor;
GN Name=Lyg2; Synonyms=Gm776;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Skin;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May act as a potent antibacterial protein that may play a
CC role in the innate immunity. {ECO:0000250|UniProtKB:Q86SG7}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 23 family. {ECO:0000305}.
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DR EMBL; AK132442; BAE21171.1; -; mRNA.
DR EMBL; BC147562; AAI47563.1; -; mRNA.
DR EMBL; BC147567; AAI47568.1; -; mRNA.
DR CCDS; CCDS14897.1; -.
DR RefSeq; NP_001028599.1; NM_001033427.3.
DR AlphaFoldDB; Q3V1I0; -.
DR SMR; Q3V1I0; -.
DR STRING; 10090.ENSMUSP00000077422; -.
DR CAZy; GH23; Glycoside Hydrolase Family 23.
DR iPTMnet; Q3V1I0; -.
DR PhosphoSitePlus; Q3V1I0; -.
DR PaxDb; Q3V1I0; -.
DR PRIDE; Q3V1I0; -.
DR ProteomicsDB; 295735; -.
DR Antibodypedia; 32804; 66 antibodies from 15 providers.
DR Ensembl; ENSMUST00000078307; ENSMUSP00000077422; ENSMUSG00000061584.
DR GeneID; 332427; -.
DR KEGG; mmu:332427; -.
DR UCSC; uc007ask.1; mouse.
DR CTD; 254773; -.
DR MGI; MGI:2685622; Lyg2.
DR VEuPathDB; HostDB:ENSMUSG00000061584; -.
DR eggNOG; ENOG502RZXI; Eukaryota.
DR GeneTree; ENSGT00390000017614; -.
DR HOGENOM; CLU_089081_0_0_1; -.
DR InParanoid; Q3V1I0; -.
DR OMA; HPTGAWD; -.
DR OrthoDB; 1255725at2759; -.
DR PhylomeDB; Q3V1I0; -.
DR TreeFam; TF329826; -.
DR BioGRID-ORCS; 332427; 1 hit in 72 CRISPR screens.
DR PRO; PR:Q3V1I0; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q3V1I0; protein.
DR Bgee; ENSMUSG00000061584; Expressed in lip and 6 other tissues.
DR Genevisible; Q3V1I0; MM.
DR GO; GO:0005576; C:extracellular region; ISO:MGI.
DR GO; GO:0003796; F:lysozyme activity; ISO:MGI.
DR GO; GO:0042742; P:defense response to bacterium; ISO:MGI.
DR GO; GO:0050830; P:defense response to Gram-positive bacterium; ISO:MGI.
DR GO; GO:0009253; P:peptidoglycan catabolic process; IEA:InterPro.
DR InterPro; IPR002152; Glyco_hydro_23.
DR InterPro; IPR023346; Lysozyme-like_dom_sf.
DR PIRSF; PIRSF001065; Lysozyme_g; 1.
DR PRINTS; PR00749; LYSOZYMEG.
DR SUPFAM; SSF53955; SSF53955; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycosidase; Hydrolase; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..213
FT /note="Lysozyme g-like protein 2"
FT /id="PRO_0000287122"
FT ACT_SITE 106
FT /evidence="ECO:0000250"
FT DISULFID 40..93
FT /evidence="ECO:0000250"
FT DISULFID 54..62
FT /evidence="ECO:0000250"
SQ SEQUENCE 213 AA; 23762 MW; 8D7735FADF8190EC CRC64;
MVPSVVFWGL IALVGTAKGS YTHSVHSMNP HVHPRLYHGC YGDIMTMETF GAPCDINNLM
NCGIHGSEMF AEMDLKAIKP YRILIKEVGQ RHCIDPALIA AIISRESHGG AVLQNGWDHK
GQRFGLMQLD KNMYHPIGSW DSKEHLLQSV GILTERIKAM KRKFPTWNTA QQLKGGLTAF
KSGMETIVTP ADIDGDLVDD VLARAKFYKR HGF
