ID   5MP2B_DANRE             Reviewed;         418 AA.
AC   Q803N9; Q58ED0; Q6NYN0;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2006, sequence version 2.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=eIF5-mimic protein 2-B {ECO:0000250|UniProtKB:Q7L1Q6};
DE   AltName: Full=Basic leucine zipper and W2 domain-containing protein 1-B;
GN   Name=bzw1b; Synonyms=5mp2b {ECO:0000250|UniProtKB:Q7L1Q6}, bzw1l;
GN   ORFNames=zgc:110545, zgc:55457, zgc:76909;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=AB; TISSUE=Embryo, and Kidney;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Translation initiation regulator which may repress repeat-
CC       associated non-AUG (RAN) initiated translation probably by acting as a
CC       competitive inhibitor of eukaryotic translation initiation factor 5
CC       (EIF5) function (By similarity). Enhances histone H4 gene transcription
CC       but does not seem to bind DNA directly (By similarity).
CC       {ECO:0000250|UniProtKB:Q7L1Q6}.
CC   -!- SIMILARITY: Belongs to the BZW family. {ECO:0000305}.
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DR   EMBL; BC044401; AAH44401.1; -; mRNA.
DR   EMBL; BC066527; AAH66527.1; -; mRNA.
DR   EMBL; BC091971; AAH91971.1; -; mRNA.
DR   RefSeq; NP_998257.1; NM_213092.1.
DR   RefSeq; XP_005167447.1; XM_005167390.3.
DR   AlphaFoldDB; Q803N9; -.
DR   SMR; Q803N9; -.
DR   STRING; 7955.ENSDARP00000002262; -.
DR   PaxDb; Q803N9; -.
DR   GeneID; 406812; -.
DR   KEGG; dre:406812; -.
DR   CTD; 406812; -.
DR   ZFIN; ZDB-GENE-040426-2881; bzw1b.
DR   eggNOG; KOG2297; Eukaryota.
DR   InParanoid; Q803N9; -.
DR   OrthoDB; 653740at2759; -.
DR   PhylomeDB; Q803N9; -.
DR   TreeFam; TF324313; -.
DR   PRO; PR:Q803N9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0006446; P:regulation of translational initiation; ISS:UniProtKB.
DR   CDD; cd11560; W2_eIF5C_like; 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR043510; W2_BZW1/2.
DR   InterPro; IPR003307; W2_domain.
DR   Pfam; PF02020; W2; 1.
DR   SMART; SM00515; eIF5C; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
DR   PROSITE; PS51363; W2; 1.
PE   2: Evidence at transcript level;
KW   Activator; Reference proteome; Transcription; Transcription regulation;
KW   Translation regulation.
FT   CHAIN           1..418
FT                   /note="eIF5-mimic protein 2-B"
FT                   /id="PRO_0000254615"
FT   DOMAIN          247..414
FT                   /note="W2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00695"
FT   REGION          1..29
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..29
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        271
FT                   /note="F -> S (in Ref. 1; AAH44401)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        304
FT                   /note="M -> A (in Ref. 1; AAH44401)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        363
FT                   /note="V -> I (in Ref. 1; AAH44401)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   418 AA;  48119 MW;  69F3536E321D7987 CRC64;
     MSYQKQQKPT LTGQRFKTRK RDEKERFDPS QFQESIVQGL NQTGTDLEAV AKFLDSSGAK
     LDYRRYAETL FDILVAGGML APGGALSDDM TRTKYCVFTA QEDIKTMKAY AQVFNKLIRR
     YKYLEKGFEE EIKKLLLFLK GFSESERNKL AMLTGVLLGN GSLSAAILSS LFNDNLVKEG
     VSPAFAVKLF KSWISEKDIN SVAGSLRKVS MDNRLMELFP VNKRSYEHFS RYFTGAGLKE
     ISDFARNQQS LGARKELQKE LQEQISLGVS FKEIIDYCKE EMKRSSISEQ LMIGIMWTSL
     MSDMEWNKKE ELVTEQAIKH LKQHSPLLKA FSTQAQSELS LLQRIQEFCY DNIHFMKTFQ
     KMVLLLYKVD VLSEEAVLKW FTEAHLAKGK SVFLEQMKTF VEWLKNAEEE SESEEESD