LYL1_MOUSE
ID LYL1_MOUSE Reviewed; 278 AA.
AC P27792; Q4FK84; Q8BPE2; Q923F0;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 14-APR-2009, sequence version 2.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Protein lyl-1;
DE AltName: Full=Lymphoblastic leukemia-derived sequence 1;
GN Name=Lyl1; Synonyms=Lyl-1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=2000219;
RA Visvader J., Begley C.G., Adams J.M.;
RT "Differential expression of the LYL, SCL and E2A helix-loop-helix genes
RT within the hemopoietic system.";
RL Oncogene 6:187-194(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=BIOA; TISSUE=Liver;
RX PubMed=2067848;
RA Kuo S.S., Mellentin J.D., Copeland N.G., Gilbert D.J., Jenkins N.A.,
RA Cleary M.L.;
RT "Structure, chromosome mapping, and expression of the mouse Lyl-1 gene.";
RL Oncogene 6:961-968(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Muenstermann E., Schatten R., Henze S., Bohn E., Mollenhauer J.,
RA Wiemann S., Schick M., Korn B.;
RT "Cloning of mouse full open reading frames in Gateway(R) system entry
RT vector (pDONR201).";
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC protein.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR EMBL; X57687; CAA40870.1; -; mRNA.
DR EMBL; X55055; CAA38896.1; -; Genomic_DNA.
DR EMBL; CT010167; CAJ18375.1; -; mRNA.
DR EMBL; AK076114; BAC36194.1; -; mRNA.
DR EMBL; AC145556; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH466525; EDL10953.1; -; Genomic_DNA.
DR EMBL; BC005736; AAH05736.1; -; mRNA.
DR CCDS; CCDS22476.1; -.
DR PIR; S16678; S16678.
DR RefSeq; NP_032561.2; NM_008535.2.
DR RefSeq; XP_006530807.1; XM_006530744.2.
DR AlphaFoldDB; P27792; -.
DR SMR; P27792; -.
DR STRING; 10090.ENSMUSP00000046010; -.
DR iPTMnet; P27792; -.
DR PhosphoSitePlus; P27792; -.
DR PaxDb; P27792; -.
DR PeptideAtlas; P27792; -.
DR PRIDE; P27792; -.
DR ProteomicsDB; 290202; -.
DR ABCD; P27792; 1 sequenced antibody.
DR Antibodypedia; 26353; 168 antibodies from 26 providers.
DR DNASU; 17095; -.
DR Ensembl; ENSMUST00000037165; ENSMUSP00000046010; ENSMUSG00000034041.
DR GeneID; 17095; -.
DR KEGG; mmu:17095; -.
DR UCSC; uc009mnb.1; mouse.
DR CTD; 4066; -.
DR MGI; MGI:96891; Lyl1.
DR VEuPathDB; HostDB:ENSMUSG00000034041; -.
DR eggNOG; KOG4029; Eukaryota.
DR GeneTree; ENSGT00940000162404; -.
DR HOGENOM; CLU_047980_1_0_1; -.
DR InParanoid; P27792; -.
DR OMA; HRVPDDG; -.
DR OrthoDB; 1453623at2759; -.
DR PhylomeDB; P27792; -.
DR TreeFam; TF315153; -.
DR BioGRID-ORCS; 17095; 4 hits in 72 CRISPR screens.
DR PRO; PR:P27792; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; P27792; protein.
DR Bgee; ENSMUSG00000034041; Expressed in granulocyte and 164 other tissues.
DR ExpressionAtlas; P27792; baseline and differential.
DR Genevisible; P27792; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0030183; P:B cell differentiation; IMP:UniProtKB.
DR GO; GO:0001955; P:blood vessel maturation; ISS:UniProtKB.
DR GO; GO:0060216; P:definitive hemopoiesis; IMP:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR040238; TAL-like.
DR PANTHER; PTHR13864; PTHR13864; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..278
FT /note="Protein lyl-1"
FT /id="PRO_0000127263"
FT DOMAIN 149..201
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 274
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P12980"
FT CONFLICT 7
FT /note="R -> G (in Ref. 1; CAA40870, 3; CAJ18375, 6;
FT EDL10953 and 7; AAH05736)"
FT /evidence="ECO:0000305"
FT CONFLICT 34
FT /note="P -> L (in Ref. 1; CAA40870, 6; EDL10953 and 7;
FT AAH05736)"
FT /evidence="ECO:0000305"
FT CONFLICT 111
FT /note="S -> R (in Ref. 2; CAA38896)"
FT /evidence="ECO:0000305"
FT CONFLICT 239
FT /note="G -> E (in Ref. 1; CAA40870, 6; EDL10953 and 7;
FT AAH05736)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 278 AA; 30142 MW; 83582AAF03C1C832 CRC64;
MCPPQARAEV GSAMTEKTEM VCASSPAPAP PSKPASPGPL STEEVDHRNT CTPWLPPGVP
VINLGHTRPI GAAMPTTELS AFRPSLLQLT ALGRAPPTLA VHYHPHPFLN SVYIGPAGPF
SIFPNSRLKR RPSHSELDLA DGHQPQKVAR RVFTNSRERW RQQHVNGAFA ELRKLLPTHP
PDRKLSKNEV LRLAMKYIGF LVRLLRDQTA VLTSGPSAPG SRKPPARRGV EGSARFGAGH
RVEAARSQPV LPGDCDGDPN GSVRPIKLEQ TSLSPEVR
