ID   LYL1_RAT                Reviewed;         278 AA.
AC   Q66HH3;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 113.
DE   RecName: Full=Protein lyl-1;
DE   AltName: Full=Lymphoblastic leukemia-derived sequence 1;
GN   Name=Lyl1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Lung;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- SUBUNIT: Efficient DNA binding requires dimerization with another bHLH
CC       protein.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00981}.
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DR   EMBL; BC081864; AAH81864.1; -; mRNA.
DR   RefSeq; NP_001007678.1; NM_001007677.1.
DR   AlphaFoldDB; Q66HH3; -.
DR   SMR; Q66HH3; -.
DR   STRING; 10116.ENSRNOP00000003980; -.
DR   PaxDb; Q66HH3; -.
DR   Ensembl; ENSRNOT00000003980; ENSRNOP00000003980; ENSRNOG00000002950.
DR   GeneID; 304663; -.
DR   KEGG; rno:304663; -.
DR   CTD; 4066; -.
DR   RGD; 1359244; Lyl1.
DR   eggNOG; KOG4029; Eukaryota.
DR   GeneTree; ENSGT00940000162404; -.
DR   HOGENOM; CLU_047980_1_0_1; -.
DR   InParanoid; Q66HH3; -.
DR   OMA; HRVPDDG; -.
DR   OrthoDB; 1453623at2759; -.
DR   PhylomeDB; Q66HH3; -.
DR   TreeFam; TF315153; -.
DR   PRO; PR:Q66HH3; -.
DR   Proteomes; UP000002494; Chromosome 19.
DR   Bgee; ENSRNOG00000002950; Expressed in spleen and 19 other tissues.
DR   Genevisible; Q66HH3; RN.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030183; P:B cell differentiation; ISS:UniProtKB.
DR   GO; GO:0001955; P:blood vessel maturation; ISS:UniProtKB.
DR   GO; GO:0060216; P:definitive hemopoiesis; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   Gene3D; 4.10.280.10; -; 1.
DR   InterPro; IPR011598; bHLH_dom.
DR   InterPro; IPR036638; HLH_DNA-bd_sf.
DR   InterPro; IPR040238; TAL-like.
DR   PANTHER; PTHR13864; PTHR13864; 1.
DR   Pfam; PF00010; HLH; 1.
DR   SMART; SM00353; HLH; 1.
DR   SUPFAM; SSF47459; SSF47459; 1.
DR   PROSITE; PS50888; BHLH; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..278
FT                   /note="Protein lyl-1"
FT                   /id="PRO_0000369264"
FT   DOMAIN          149..201
FT                   /note="bHLH"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT   REGION          1..52
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          213..278
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         274
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P12980"
SQ   SEQUENCE   278 AA;  29957 MW;  8B2873F2BA288839 CRC64;
     MCPPQAQAEV GSAMTEKTEM VCTSSPAPAP PSKPASPGPL PAEEVDHRNT CNPWLPPGVP
     VINLGHTRPT GAAMPTTELS AFRPSLLQLA ALGTAPPTLA LHYHPHPFLN SVYIGPAGPF
     SIFPNSRLKR RPSHGELDLV DGHQPQKVAR RVFTNSRERW RQQHVNGAFA ELRKLLPTHP
     PDRKLSKNEV LRLAMKYIGF LVRLLRDQAA VLASGPSAPG SRKPPAHRGV EGNARCGAGH
     RVEAARSQPV LPGDCDGDPN GSVRPIKMEQ TALSPEVR