LYPD2_HUMAN
ID LYPD2_HUMAN Reviewed; 125 AA.
AC Q6UXB3; A8K2R6; Q0VD64; Q0VF31;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Ly6/PLAUR domain-containing protein 2;
DE Flags: Precursor;
GN Name=LYPD2; Synonyms=LYPDC2; ORFNames=UNQ430/PRO788;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- INTERACTION:
CC Q6UXB3; Q12837: POU4F2; NbExp=3; IntAct=EBI-18270828, EBI-17236143;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC anchor {ECO:0000305}.
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DR EMBL; AY358432; AAQ88798.1; -; mRNA.
DR EMBL; AK290331; BAF83020.1; -; mRNA.
DR EMBL; BC119019; AAI19020.1; -; mRNA.
DR EMBL; BC119812; AAI19813.1; -; mRNA.
DR CCDS; CCDS6388.1; -.
DR RefSeq; NP_991108.1; NM_205545.2.
DR AlphaFoldDB; Q6UXB3; -.
DR SMR; Q6UXB3; -.
DR BioGRID; 126484; 16.
DR IntAct; Q6UXB3; 1.
DR STRING; 9606.ENSP00000352163; -.
DR GlyGen; Q6UXB3; 1 site.
DR BioMuta; LYPD2; -.
DR DMDM; 74749418; -.
DR jPOST; Q6UXB3; -.
DR MassIVE; Q6UXB3; -.
DR PaxDb; Q6UXB3; -.
DR PeptideAtlas; Q6UXB3; -.
DR PRIDE; Q6UXB3; -.
DR ProteomicsDB; 67584; -.
DR Antibodypedia; 27786; 42 antibodies from 10 providers.
DR DNASU; 137797; -.
DR Ensembl; ENST00000359228.4; ENSP00000352163.3; ENSG00000197353.4.
DR GeneID; 137797; -.
DR KEGG; hsa:137797; -.
DR MANE-Select; ENST00000359228.4; ENSP00000352163.3; NM_205545.3; NP_991108.1.
DR UCSC; uc003ywz.4; human.
DR CTD; 137797; -.
DR GeneCards; LYPD2; -.
DR HGNC; HGNC:25215; LYPD2.
DR HPA; ENSG00000197353; Tissue enriched (esophagus).
DR neXtProt; NX_Q6UXB3; -.
DR OpenTargets; ENSG00000197353; -.
DR PharmGKB; PA134911921; -.
DR VEuPathDB; HostDB:ENSG00000197353; -.
DR eggNOG; ENOG502SG63; Eukaryota.
DR GeneTree; ENSGT00940000162197; -.
DR HOGENOM; CLU_141358_2_0_1; -.
DR InParanoid; Q6UXB3; -.
DR OMA; RCYVCPE; -.
DR OrthoDB; 1592016at2759; -.
DR PhylomeDB; Q6UXB3; -.
DR TreeFam; TF336080; -.
DR PathwayCommons; Q6UXB3; -.
DR Reactome; R-HSA-163125; Post-translational modification: synthesis of GPI-anchored proteins.
DR SignaLink; Q6UXB3; -.
DR BioGRID-ORCS; 137797; 29 hits in 1061 CRISPR screens.
DR GenomeRNAi; 137797; -.
DR Pharos; Q6UXB3; Tdark.
DR PRO; PR:Q6UXB3; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; Q6UXB3; protein.
DR Bgee; ENSG00000197353; Expressed in lower esophagus mucosa and 65 other tissues.
DR ExpressionAtlas; Q6UXB3; baseline and differential.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR CDD; cd00117; LU; 1.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR018363; CD59_antigen_CS.
DR InterPro; IPR016054; LY6_UPA_recep-like.
DR InterPro; IPR040188; LYPD2.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR InterPro; IPR035076; Toxin/TOLIP.
DR PANTHER; PTHR10036:SF11; PTHR10036:SF11; 1.
DR Pfam; PF00087; Toxin_TOLIP; 1.
DR SMART; SM00134; LU; 1.
DR SUPFAM; SSF57302; SSF57302; 1.
DR PROSITE; PS00983; LY6_UPAR; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW Reference proteome; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..103
FT /note="Ly6/PLAUR domain-containing protein 2"
FT /id="PRO_0000226747"
FT PROPEP 104..125
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000226748"
FT DOMAIN 25..100
FT /note="UPAR/Ly6"
FT LIPID 103
FT /note="GPI-anchor amidated glycine"
FT /evidence="ECO:0000255"
FT CARBOHYD 46
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VARIANT 5
FT /note="R -> Q (in dbSNP:rs11778314)"
FT /id="VAR_052701"
FT VARIANT 7
FT /note="A -> V (in dbSNP:rs11775636)"
FT /id="VAR_052702"
FT CONFLICT 4
FT /note="T -> A (in Ref. 2; BAF83020)"
FT /evidence="ECO:0000305"
FT CONFLICT 5..7
FT /note="RLA -> QLV (in Ref. 3; AAI19020)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 125 AA; 13115 MW; F727D41D50F57756 CRC64;
MRGTRLALLA LVLAACGELA PALRCYVCPE PTGVSDCVTI ATCTTNETMC KTTLYSREIV
YPFQGDSTVT KSCASKCKPS DVDGIGQTLP VSCCNTELCN VDGAPALNSL HCGALTLLPL
LSLRL
