LYPD2_MOUSE
ID LYPD2_MOUSE Reviewed; 127 AA.
AC Q9DD23; A2RT83;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Ly6/PLAUR domain-containing protein 2;
DE AltName: Full=Protein H8C4;
DE Flags: Precursor;
GN Name=Lypd2; Synonyms=Lypdc2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Kidney;
RA Mori K., Ogawa Y., Tashiro K., Ozaki S., Mukoyama M., Tanaka I., Nakao K.;
RT "Molecular cloning of a novel GPI-anchor type protein.";
RL Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Thyroid;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC anchor {ECO:0000305}.
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DR EMBL; AB009019; BAF80620.1; -; mRNA.
DR EMBL; AK002226; BAB21948.1; -; mRNA.
DR EMBL; BC099511; AAH99511.1; -; mRNA.
DR EMBL; BC132407; AAI32408.1; -; mRNA.
DR EMBL; BC132409; AAI32410.1; -; mRNA.
DR CCDS; CCDS27529.1; -.
DR RefSeq; NP_080947.1; NM_026671.1.
DR RefSeq; XP_006521375.1; XM_006521312.1.
DR AlphaFoldDB; Q9DD23; -.
DR SMR; Q9DD23; -.
DR STRING; 10090.ENSMUSP00000023260; -.
DR GlyGen; Q9DD23; 1 site.
DR MaxQB; Q9DD23; -.
DR PaxDb; Q9DD23; -.
DR PRIDE; Q9DD23; -.
DR Antibodypedia; 27786; 42 antibodies from 10 providers.
DR Ensembl; ENSMUST00000023260; ENSMUSP00000023260; ENSMUSG00000022595.
DR GeneID; 68311; -.
DR KEGG; mmu:68311; -.
DR UCSC; uc007wfu.1; mouse.
DR CTD; 137797; -.
DR MGI; MGI:1915561; Lypd2.
DR VEuPathDB; HostDB:ENSMUSG00000022595; -.
DR eggNOG; ENOG502SG63; Eukaryota.
DR GeneTree; ENSGT00940000162197; -.
DR HOGENOM; CLU_141358_2_0_1; -.
DR InParanoid; Q9DD23; -.
DR OMA; RCYVCPE; -.
DR OrthoDB; 1592016at2759; -.
DR PhylomeDB; Q9DD23; -.
DR TreeFam; TF336080; -.
DR Reactome; R-MMU-163125; Post-translational modification: synthesis of GPI-anchored proteins.
DR BioGRID-ORCS; 68311; 2 hits in 71 CRISPR screens.
DR PRO; PR:Q9DD23; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q9DD23; protein.
DR Bgee; ENSMUSG00000022595; Expressed in olfactory epithelium and 64 other tissues.
DR Genevisible; Q9DD23; MM.
DR GO; GO:0031225; C:anchored component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00117; LU; 1.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR016054; LY6_UPA_recep-like.
DR InterPro; IPR040188; LYPD2.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR InterPro; IPR035076; Toxin/TOLIP.
DR PANTHER; PTHR10036:SF11; PTHR10036:SF11; 1.
DR Pfam; PF00087; Toxin_TOLIP; 1.
DR SMART; SM00134; LU; 1.
DR SUPFAM; SSF57302; SSF57302; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW Reference proteome; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..106
FT /note="Ly6/PLAUR domain-containing protein 2"
FT /id="PRO_0000226749"
FT PROPEP 107..127
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000226750"
FT DOMAIN 25..100
FT /note="UPAR/Ly6"
FT LIPID 106
FT /note="GPI-anchor amidated serine"
FT /evidence="ECO:0000255"
FT CARBOHYD 46
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 127 AA; 13280 MW; 9CCE20688671882C CRC64;
MQGTWMVLLA LILGTFGELA MALQCYTCAN PVSASNCVTT THCHINETMC KTTLYSLEIV
FPFLGDSTVT KSCASKCEPS DVDGIGQTRP VSCCNSDLCN VDGAPSLGSP GGLLLALALF
LLLGVLL
