LYPD4_HUMAN
ID LYPD4_HUMAN Reviewed; 246 AA.
AC Q6UWN0; Q8IYW0;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 2.
DT 03-AUG-2022, entry version 129.
DE RecName: Full=Ly6/PLAUR domain-containing protein 4;
DE Flags: Precursor;
GN Name=LYPD4; ORFNames=UNQ2552/PRO6181;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=12975309; DOI=10.1101/gr.1293003;
RA Clark H.F., Gurney A.L., Abaya E., Baker K., Baldwin D.T., Brush J.,
RA Chen J., Chow B., Chui C., Crowley C., Currell B., Deuel B., Dowd P.,
RA Eaton D., Foster J.S., Grimaldi C., Gu Q., Hass P.E., Heldens S., Huang A.,
RA Kim H.S., Klimowski L., Jin Y., Johnson S., Lee J., Lewis L., Liao D.,
RA Mark M.R., Robbie E., Sanchez C., Schoenfeld J., Seshagiri S., Simmons L.,
RA Singh J., Smith V., Stinson J., Vagts A., Vandlen R.L., Watanabe C.,
RA Wieand D., Woods K., Xie M.-H., Yansura D.G., Yi S., Yu G., Yuan J.,
RA Zhang M., Zhang Z., Goddard A.D., Wood W.I., Godowski P.J., Gray A.M.;
RT "The secreted protein discovery initiative (SPDI), a large-scale effort to
RT identify novel human secreted and transmembrane proteins: a bioinformatics
RT assessment.";
RL Genome Res. 13:2265-2270(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC anchor {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6UWN0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6UWN0-2; Sequence=VSP_017506;
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DR EMBL; AY358726; AAQ89088.1; -; mRNA.
DR EMBL; BC034629; AAH34629.1; -; mRNA.
DR CCDS; CCDS12587.1; -. [Q6UWN0-1]
DR CCDS; CCDS77303.1; -. [Q6UWN0-2]
DR RefSeq; NP_001278348.1; NM_001291419.1. [Q6UWN0-2]
DR RefSeq; NP_775777.3; NM_173506.6. [Q6UWN0-1]
DR AlphaFoldDB; Q6UWN0; -.
DR SMR; Q6UWN0; -.
DR BioGRID; 127081; 139.
DR IntAct; Q6UWN0; 68.
DR STRING; 9606.ENSP00000476510; -.
DR GlyGen; Q6UWN0; 1 site.
DR iPTMnet; Q6UWN0; -.
DR PhosphoSitePlus; Q6UWN0; -.
DR BioMuta; LYPD4; -.
DR DMDM; 92058726; -.
DR jPOST; Q6UWN0; -.
DR MassIVE; Q6UWN0; -.
DR PaxDb; Q6UWN0; -.
DR PeptideAtlas; Q6UWN0; -.
DR PRIDE; Q6UWN0; -.
DR ProteomicsDB; 67502; -. [Q6UWN0-1]
DR ProteomicsDB; 67503; -. [Q6UWN0-2]
DR Antibodypedia; 72432; 111 antibodies from 16 providers.
DR DNASU; 147719; -.
DR Ensembl; ENST00000343055.5; ENSP00000339568.4; ENSG00000273111.6. [Q6UWN0-2]
DR Ensembl; ENST00000601246.5; ENSP00000472570.1; ENSG00000273111.6. [Q6UWN0-2]
DR Ensembl; ENST00000609812.6; ENSP00000476510.1; ENSG00000273111.6. [Q6UWN0-1]
DR GeneID; 147719; -.
DR KEGG; hsa:147719; -.
DR MANE-Select; ENST00000609812.6; ENSP00000476510.1; NM_173506.7; NP_775777.3.
DR UCSC; uc032hyg.2; human. [Q6UWN0-1]
DR CTD; 147719; -.
DR DisGeNET; 147719; -.
DR GeneCards; LYPD4; -.
DR HGNC; HGNC:28659; LYPD4.
DR HPA; ENSG00000273111; Tissue enriched (testis).
DR neXtProt; NX_Q6UWN0; -.
DR OpenTargets; ENSG00000273111; -.
DR PharmGKB; PA142671491; -.
DR VEuPathDB; HostDB:ENSG00000273111; -.
DR eggNOG; ENOG502RNFS; Eukaryota.
DR GeneTree; ENSGT00530000063351; -.
DR HOGENOM; CLU_108759_0_0_1; -.
DR InParanoid; Q6UWN0; -.
DR OMA; CKLSEGC; -.
DR OrthoDB; 1092756at2759; -.
DR PhylomeDB; Q6UWN0; -.
DR TreeFam; TF337286; -.
DR PathwayCommons; Q6UWN0; -.
DR Reactome; R-HSA-163125; Post-translational modification: synthesis of GPI-anchored proteins.
DR SignaLink; Q6UWN0; -.
DR BioGRID-ORCS; 147719; 15 hits in 1058 CRISPR screens.
DR GenomeRNAi; 147719; -.
DR Pharos; Q6UWN0; Tbio.
DR PRO; PR:Q6UWN0; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q6UWN0; protein.
DR Bgee; ENSG00000273111; Expressed in sperm and 45 other tissues.
DR ExpressionAtlas; Q6UWN0; baseline and differential.
DR Genevisible; Q6UWN0; HS.
DR GO; GO:0046658; C:anchored component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR GO; GO:0044853; C:plasma membrane raft; IBA:GO_Central.
DR InterPro; IPR016054; LY6_UPA_recep-like.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR Pfam; PF00021; UPAR_LY6; 1.
DR SUPFAM; SSF57302; SSF57302; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein;
KW Membrane; Reference proteome; Repeat; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..225
FT /note="Ly6/PLAUR domain-containing protein 4"
FT /id="PRO_0000226759"
FT PROPEP 226..246
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000226760"
FT DOMAIN 142..223
FT /note="UPAR/Ly6"
FT LIPID 225
FT /note="GPI-anchor amidated alanine"
FT /evidence="ECO:0000255"
FT CARBOHYD 117
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 24..70
FT /note="AGALLCYEATASRFRAVAFHNWKWLLMRNMVCKLQEGCEETLVFIET -> M
FT SCGAGCYKTQK (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_017506"
FT VARIANT 184
FT /note="T -> S (in dbSNP:rs35476281)"
FT /id="VAR_052703"
FT CONFLICT 19
FT /note="S -> P (in Ref. 1; AAQ89088)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 246 AA; 26763 MW; E09D9EB8FE9CEA5D CRC64;
MGPQHLRLVQ LFCLLGAIST LPRAGALLCY EATASRFRAV AFHNWKWLLM RNMVCKLQEG
CEETLVFIET GTARGVVGFK GCSSSSSYPA QISYLVSPPG VSIASYSRVC RSYLCNNLTN
LEPFVKLKAS TPKSITSASC SCPTCVGEHM KDCLPNFVTT NSCPLAASTC YSSTLKFQAG
FLNTTFLLMG CAREHNQLLA DFHHIGSIKV TEVLNILEKS QIVGAASSRQ DPAWGVVLGL
LFAFRD
