LYPD4_MOUSE
ID LYPD4_MOUSE Reviewed; 246 AA.
AC Q8BVP6;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Ly6/PLAUR domain-containing protein 4;
DE Flags: Precursor;
GN Name=Lypd4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Lipid-anchor, GPI-
CC anchor {ECO:0000305}.
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DR EMBL; AK077071; BAC36592.1; -; mRNA.
DR EMBL; BC049744; AAH49744.1; -; mRNA.
DR CCDS; CCDS20964.1; -.
DR RefSeq; NP_877586.1; NM_182785.3.
DR RefSeq; XP_011248819.1; XM_011250517.2.
DR AlphaFoldDB; Q8BVP6; -.
DR SMR; Q8BVP6; -.
DR STRING; 10090.ENSMUSP00000078287; -.
DR GlyGen; Q8BVP6; 1 site.
DR PhosphoSitePlus; Q8BVP6; -.
DR PaxDb; Q8BVP6; -.
DR PRIDE; Q8BVP6; -.
DR ProteomicsDB; 252691; -.
DR Antibodypedia; 72432; 111 antibodies from 16 providers.
DR DNASU; 232973; -.
DR Ensembl; ENSMUST00000079306; ENSMUSP00000078287; ENSMUSG00000062732.
DR GeneID; 232973; -.
DR KEGG; mmu:232973; -.
DR UCSC; uc009fqo.1; mouse.
DR CTD; 147719; -.
DR MGI; MGI:2687054; Lypd4.
DR VEuPathDB; HostDB:ENSMUSG00000062732; -.
DR eggNOG; ENOG502RNFS; Eukaryota.
DR GeneTree; ENSGT00530000063351; -.
DR HOGENOM; CLU_108759_0_0_1; -.
DR InParanoid; Q8BVP6; -.
DR OMA; CKLSEGC; -.
DR OrthoDB; 1092756at2759; -.
DR PhylomeDB; Q8BVP6; -.
DR TreeFam; TF337286; -.
DR Reactome; R-MMU-163125; Post-translational modification: synthesis of GPI-anchored proteins.
DR BioGRID-ORCS; 232973; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Lypd4; mouse.
DR PRO; PR:Q8BVP6; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8BVP6; protein.
DR Bgee; ENSMUSG00000062732; Expressed in seminiferous tubule of testis and 9 other tissues.
DR ExpressionAtlas; Q8BVP6; baseline and differential.
DR Genevisible; Q8BVP6; MM.
DR GO; GO:0046658; C:anchored component of plasma membrane; IBA:GO_Central.
DR GO; GO:0044853; C:plasma membrane raft; IBA:GO_Central.
DR Gene3D; 2.10.60.10; -; 1.
DR InterPro; IPR016054; LY6_UPA_recep-like.
DR InterPro; IPR045860; Snake_toxin-like_sf.
DR Pfam; PF00021; UPAR_LY6; 1.
DR SUPFAM; SSF57302; SSF57302; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Glycoprotein; GPI-anchor; Lipoprotein; Membrane;
KW Reference proteome; Repeat; Signal.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..225
FT /note="Ly6/PLAUR domain-containing protein 4"
FT /id="PRO_0000226761"
FT PROPEP 226..246
FT /note="Removed in mature form"
FT /evidence="ECO:0000255"
FT /id="PRO_0000226762"
FT DOMAIN 142..223
FT /note="UPAR/Ly6"
FT LIPID 225
FT /note="GPI-anchor amidated alanine"
FT /evidence="ECO:0000255"
FT CARBOHYD 117
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 246 AA; 26996 MW; 9D5FA13F10CC279D CRC64;
MILQAWRSLQ LLYLLEAISL LPCTEALLCY EATASAFRAV SLHNWKWLLL RSMVCNQREG
CEETVVFIET GTSKGVLSFK GCSSAFSYPP QISYLVSPPG VSIASYSRVC RSYLCNNLTN
LEPFVRLKAS QPMSTLPSAK SCPSCVGKHD QECLPSFVTT ENCPFAASSC YSSTLKFQAG
NLNTTFLIMG CARDSHKLLA DFQHIGSIRV TEVINVLDKS EAVSAGHCSQ GISWSVLLCL
LILLRD
